Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris

• Published in: Scientific reports Vol. 13; no. 1; p. 22666
• Main Authors: An, Senyou, Yu, Huidan, Islam, MD Mahfuzul, Zhang, Xiaoyu, Zhan, Yuting, Olivieri, Joseph J., Ambati, Jayakrishna, Yao, Jun, Gelfand, Bradley D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/61; 692/308/575; 692/420; 692/698; 692/699; 692/699/3161; 692/699/3161/1626; Age; Anatomy; Choroid - blood supply; Hemodynamics; Heterogeneity; Histopathology; Humanities and Social Sciences; Humans; Macular degeneration; Macular Degeneration - pathology; Microvasculature; multidisciplinary; Perfusion; Retina; Science; Science (multidisciplinary); Shear stress; Spatial distribution; Spatial heterogeneity; Velocity

Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. The...