Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris

Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. The...

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Published inScientific reports Vol. 13; no. 1; p. 22666
Main Authors An, Senyou, Yu, Huidan, Islam, MD Mahfuzul, Zhang, Xiaoyu, Zhan, Yuting, Olivieri, Joseph J., Ambati, Jayakrishna, Yao, Jun, Gelfand, Bradley D.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 19.12.2023
Nature Publishing Group
Nature Portfolio
Subjects
631/61
692/308/575
692/420
692/698
692/699
692/699/3161
692/699/3161/1626
Age
Anatomy
Choroid - blood supply
Hemodynamics
Heterogeneity
Histopathology
Humanities and Social Sciences
Humans
Macular degeneration
Macular Degeneration - pathology
Microvasculature
multidisciplinary
Perfusion
Retina
Science
Science (multidisciplinary)
Shear stress
Spatial distribution
Spatial heterogeneity
Velocity
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Abstract Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. Therefore, we sought to understand the influences of choroidal microvascular architecture on the spatial distribution of hemodynamic parameters in choriocapillaris from human donor eyes using image-based computational hemodynamic (ICH) simulations. We subjected image-based inner choroid reconstructions from eight human donor eyes to ICH simulation using a kinetic-based volumetric lattice Boltzmann method to compute hemodynamic distributions of velocity, pressure, and endothelial shear stress. Here, we demonstrate that anatomic parameters, including arteriolar and venular arrangements and intercapillary pillar density and distribution exert profound influences on inner choroidal hemodynamic characteristics. Reductions in capillary, arteriolar, and venular density not only reduce the overall blood velocity within choriocapillaris, but also substantially increase its spatial heterogeneity. These first-ever findings improve understanding of how choroidal anatomy affects hemodynamics and may contribute to pathogenesis of retinal diseases such as AMD.
AbstractList Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. Therefore, we sought to understand the influences of choroidal microvascular architecture on the spatial distribution of hemodynamic parameters in choriocapillaris from human donor eyes using image-based computational hemodynamic (ICH) simulations. We subjected image-based inner choroid reconstructions from eight human donor eyes to ICH simulation using a kinetic-based volumetric lattice Boltzmann method to compute hemodynamic distributions of velocity, pressure, and endothelial shear stress. Here, we demonstrate that anatomic parameters, including arteriolar and venular arrangements and intercapillary pillar density and distribution exert profound influences on inner choroidal hemodynamic characteristics. Reductions in capillary, arteriolar, and venular density not only reduce the overall blood velocity within choriocapillaris, but also substantially increase its spatial heterogeneity. These first-ever findings improve understanding of how choroidal anatomy affects hemodynamics and may contribute to pathogenesis of retinal diseases such as AMD.
Abstract Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases such as age-related macular degeneration (AMD). However, how inner choroidal anatomy affects hemodynamic perfusion is not well understood. Therefore, we sought to understand the influences of choroidal microvascular architecture on the spatial distribution of hemodynamic parameters in choriocapillaris from human donor eyes using image-based computational hemodynamic (ICH) simulations. We subjected image-based inner choroid reconstructions from eight human donor eyes to ICH simulation using a kinetic-based volumetric lattice Boltzmann method to compute hemodynamic distributions of velocity, pressure, and endothelial shear stress. Here, we demonstrate that anatomic parameters, including arteriolar and venular arrangements and intercapillary pillar density and distribution exert profound influences on inner choroidal hemodynamic characteristics. Reductions in capillary, arteriolar, and venular density not only reduce the overall blood velocity within choriocapillaris, but also substantially increase its spatial heterogeneity. These first-ever findings improve understanding of how choroidal anatomy affects hemodynamics and may contribute to pathogenesis of retinal diseases such as AMD.
ArticleNumber 22666
Author Zhan, Yuting
Olivieri, Joseph J.
Gelfand, Bradley D.
Yao, Jun
Ambati, Jayakrishna
An, Senyou
Yu, Huidan
Zhang, Xiaoyu
Islam, MD Mahfuzul
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Snippet Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal diseases...
Abstract Evidence from histopathology and clinical imaging suggest that choroidal anatomy and hemodynamic perfusion are among the earliest changes in retinal...
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SubjectTerms 631/61
692/308/575
692/420
692/698
692/699
692/699/3161
692/699/3161/1626
Age
Anatomy
Choroid - blood supply
Hemodynamics
Heterogeneity
Histopathology
Humanities and Social Sciences
Humans
Macular degeneration
Macular Degeneration - pathology
Microvasculature
multidisciplinary
Perfusion
Retina
Science
Science (multidisciplinary)
Shear stress
Spatial distribution
Spatial heterogeneity
Velocity
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Title Effects of donor-specific microvascular anatomy on hemodynamic perfusion in human choriocapillaris
URI https://link.springer.com/article/10.1038/s41598-023-48631-2
https://www.ncbi.nlm.nih.gov/pubmed/38114564
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https://search.proquest.com/docview/2904156702
https://pubmed.ncbi.nlm.nih.gov/PMC10730623
https://doaj.org/article/8d3673d07e604e98a54eb7be2af1f171
Volume 13
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