Chemically programmed STING-activating nano-liposomal vesicles improve anticancer immunity

• Published in: Nature communications Vol. 14; no. 1; pp. 4584 - 15
• Main Authors: Chen, Xiaona, Meng, Fanchao, Xu, Yiting, Li, Tongyu, Chen, Xiaolong, Wang, Hangxiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 31.07.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/21; 13/31; 13/51; 631/250/580/1884; 631/67/327; 631/92/152; 64/60; 64/86; 692/308/153; Adaptive immunity; Agonists; Animal models; Animals; Breast cancer; Cancer therapies; Cell Line, Tumor; Cytokines; Drugs; Humanities and Social Sciences; Immune checkpoint inhibitors; Immunosuppressive agents; Immunotherapy; Infectious diseases; Inflammation; Intravenous administration; Kinases; Liposomes; Medical diagnosis; Melanoma; Melanoma - drug therapy; Metastases; Metastasis; Mice; multidisciplinary; Nucleotides; Pharmacokinetics; Prodrugs; Remission; Remission (Medicine); Science; Science (multidisciplinary); Toxicity; Tumor Microenvironment; Tumors

The often immune-suppressive tumor microenvironment (TME) may hinder immune evasion and response to checkpoint blockade therapies. Pharmacological activation of the STING pathway does create an immunologically hot TME, however, systemic delivery might lead to undesired off-target inflammatory respon...