Mechanism and therapeutic implications of pomalidomide-induced immune surface marker upregulation in EBV-positive lymphomas

• Published in: Scientific reports Vol. 13; no. 1; pp. 11596 - 15
• Main Authors: Jaeger, Hannah K., Davis, David A., Nair, Ashwin, Shrestha, Prabha, Stream, Alexandra, Yaparla, Amulya, Yarchoan, Robert
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.07.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 631/67; 631/67/1059; 631/67/1858; AKT protein; CD86 antigen; Cytokines; Epstein-Barr virus; Gene expression; Humanities and Social Sciences; Ikaros protein; Inflammation; IP-10 protein; Kinases; Lymphoma; mRNA; multidisciplinary; Phosphorylation; PU.1 protein; Science; Science (multidisciplinary); Surface markers; Tumor cells; Up-regulation

Epstein-Barr virus (EBV) downregulates immune surface markers to avoid immune recognition. Pomalidomide (Pom) was previously shown to increase immune surface marker expression in EBV-infected tumor cells. We explored the mechanism by which Pom leads to these effects in EBV-infected cells. Pom increa...