Dual-functional porous and cisplatin-loaded polymethylmethacrylate cement for reconstruction of load-bearing bone defect kills bone tumor cells

• Published in: Bioactive materials Vol. 15; pp. 120 - 130
• Main Authors: Wang, Zhule, Nogueira, Liebert Parreiras, Haugen, Håvard Jostein, Van Der Geest, Ingrid CM, de Almeida Rodrigues, Patricia Caetano, Janssen, Dennis, Bitter, Thom, van den Beucken, Jeroen J.J.P., Leeuwenburgh, Sander CG
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.09.2022; KeAi Publishing; KeAi Communications Co., Ltd
• Subjects: Bone tumor treatment; Chemotherapeutic drug; Ex vivo biomechanical assessment; Local drug delivery; Porous polymethylmethacrylate cement; Ex vivo biomechanical assessment; Bone tumor treatment; Local drug delivery; Porous polymethylmethacrylate cement; Chemotherapeutic drug

Malignant bone tumors are usually treated by resection of tumor tissue followed by filling of the bone defect with bone graft substitutes. Polymethylmethacrylate (PMMA) cement is the most commonly used bone substitute in clinical orthopedics in view of its reliability. However, the dense nature of P...