The increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson’s disease
The role of carcinoembryonic antigen (CEA) in Parkinson’s disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients wi...
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| Published in | Neurological sciences Vol. 36; no. 3; pp. 423 - 428 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Milan
Springer Milan
01.03.2015
Springer Nature B.V |
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| Online Access | Get full text |
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| Abstract | The role of carcinoembryonic antigen (CEA) in Parkinson’s disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients with Parkinson’s disease and to examine the relationship between these inflammatory markers. The cross-sectional design includes 51 patients with Parkinson’s disease and 50 age- and sex-matched healthy controls. We investigated the differences in hs-CRP, CEA, and NLR levels between these two groups. CEA was significantly higher in PD patients relative to the control group (mean 2.40 ± 1.51 vs. 1.72 ± 0.87 (ng/mL), respectively;
p
= 0.015). Mean NLR was significantly higher in PD patients relative to the control group (mean 3.1 ± 1.3 vs. 2.1 ± 0.32, respectively;
p
< 0.001). Serum level of hs-CRP was higher in PD patients than in control group (mean 1.04 ± 0.62 and 0.54 ± 0.31, respectively;
p
< 0.01). Correlation analysis revealed significant correlation between hs-CRP, CEA, and Neutrophil/lymphocyte ratio (
p
< 0.05). This study demonstrates for the first time the association between CEA, hs-CRP, NLR, and PD. We found CEA, hs-CRP, and NLR levels to be significantly higher in the PD patients than in the normal controls. |
|---|---|
| AbstractList | The role of carcinoembryonic antigen (CEA) in Parkinson's disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients with Parkinson's disease and to examine the relationship between these inflammatory markers. The cross-sectional design includes 51 patients with Parkinson's disease and 50 age- and sex-matched healthy controls. We investigated the differences in hs-CRP, CEA, and NLR levels between these two groups. CEA was significantly higher in PD patients relative to the control group (mean 2.40 ± 1.51 vs. 1.72 ± 0.87 (ng/mL), respectively; p = 0.015). Mean NLR was significantly higher in PD patients relative to the control group (mean 3.1 ± 1.3 vs. 2.1 ± 0.32, respectively; p < 0.001). Serum level of hs-CRP was higher in PD patients than in control group (mean 1.04 ± 0.62 and 0.54 ± 0.31, respectively; p < 0.01). Correlation analysis revealed significant correlation between hs-CRP, CEA, and Neutrophil/lymphocyte ratio (p < 0.05). This study demonstrates for the first time the association between CEA, hs-CRP, NLR, and PD. We found CEA, hs-CRP, and NLR levels to be significantly higher in the PD patients than in the normal controls. The role of carcinoembryonic antigen (CEA) in Parkinson’s disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients with Parkinson’s disease and to examine the relationship between these inflammatory markers. The cross-sectional design includes 51 patients with Parkinson’s disease and 50 age- and sex-matched healthy controls. We investigated the differences in hs-CRP, CEA, and NLR levels between these two groups. CEA was significantly higher in PD patients relative to the control group (mean 2.40 ± 1.51 vs. 1.72 ± 0.87 (ng/mL), respectively; p = 0.015). Mean NLR was significantly higher in PD patients relative to the control group (mean 3.1 ± 1.3 vs. 2.1 ± 0.32, respectively; p < 0.001). Serum level of hs-CRP was higher in PD patients than in control group (mean 1.04 ± 0.62 and 0.54 ± 0.31, respectively; p < 0.01). Correlation analysis revealed significant correlation between hs-CRP, CEA, and Neutrophil/lymphocyte ratio ( p < 0.05). This study demonstrates for the first time the association between CEA, hs-CRP, NLR, and PD. We found CEA, hs-CRP, and NLR levels to be significantly higher in the PD patients than in the normal controls. The role of carcinoembryonic antigen (CEA) in Parkinson's disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients with Parkinson's disease and to examine the relationship between these inflammatory markers. The cross-sectional design includes 51 patients with Parkinson's disease and 50 age- and sex-matched healthy controls. We investigated the differences in hs-CRP, CEA, and NLR levels between these two groups. CEA was significantly higher in PD patients relative to the control group (mean 2.40 plus or minus 1.51 vs. 1.72 plus or minus 0.87 (ng/mL), respectively; p = 0.015). Mean NLR was significantly higher in PD patients relative to the control group (mean 3.1 plus or minus 1.3 vs. 2.1 plus or minus 0.32, respectively; p < 0.001). Serum level of hs-CRP was higher in PD patients than in control group (mean 1.04 plus or minus 0.62 and 0.54 plus or minus 0.31, respectively; p < 0.01). Correlation analysis revealed significant correlation between hs-CRP, CEA, and Neutrophil/lymphocyte ratio (p < 0.05). This study demonstrates for the first time the association between CEA, hs-CRP, NLR, and PD. We found CEA, hs-CRP, and NLR levels to be significantly higher in the PD patients than in the normal controls. |
| Author | Kaplan, İbrahim Arslan, Demet Aluçlu, Mehmet Ufuk Özdemir, Hasan Hüseyin Akıl, Eşref Bulut, Aslıhan |
| Author_xml | – sequence: 1 givenname: Eşref surname: Akıl fullname: Akıl, Eşref email: esrefakil@gmail.com organization: Department of Neurology, Faculty of Medicine, Dicle University – sequence: 2 givenname: Aslıhan surname: Bulut fullname: Bulut, Aslıhan organization: Department of Neurology, Special EGM Hayat Hospital – sequence: 3 givenname: İbrahim surname: Kaplan fullname: Kaplan, İbrahim organization: Department of Biochemistry, Faculty of Medicine, Dicle University – sequence: 4 givenname: Hasan Hüseyin surname: Özdemir fullname: Özdemir, Hasan Hüseyin organization: Department of Neurology, Faculty of Medicine, Dicle University – sequence: 5 givenname: Demet surname: Arslan fullname: Arslan, Demet organization: Department of Neurology, Faculty of Medicine, Dicle University – sequence: 6 givenname: Mehmet Ufuk surname: Aluçlu fullname: Aluçlu, Mehmet Ufuk organization: Department of Neurology, Faculty of Medicine, Dicle University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25288159$$D View this record in MEDLINE/PubMed |
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| Keywords | Carcinoembryonic antigen High-sensitivity C-reactive protein Peripheral inflammation Parkinson’s disease Neutrophil/lymphocyte ratio |
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| SubjectTerms | Aged C-Reactive Protein - analysis Carcinoembryonic Antigen - blood Cross-Sectional Studies Female Humans Leukocyte Count Lymphocytes Male Medicine Medicine & Public Health Middle Aged Neurology Neuroradiology Neurosciences Neurosurgery Neutrophils Original Article Parkinson Disease - blood Psychiatry ROC Curve |
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| Title | The increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson’s disease |
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