The interaction between UBR7 and PRMT5 drives PDAC resistance to gemcitabine by regulating glycolysis and immune microenvironment - Feng, Maoxiao; Jiao, Qinlian; Ren, Yidan; Liu, Xiaoyan; Gao, Zihan; Li, Zhengjun; Wang, Yunshan; Zhao, Miaoqing; Bi, Lei (Cell death & disease, 2024)
Keywords: 38; 38/91; 631/67/1059; 692/308/409; Adenocarcinoma; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Carcinogenesis; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Cell Biology; Cell Culture; Cell Line, Tumor; Chromatin; Deoxycytidine - analogs & derivatives; Deoxycytidine - pharmacology; Deoxycytidine - therapeutic use; Drug resistance; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Gastrointestinal tract; Gemcitabine; Gene expression; Gene Expression Regulation, Neoplastic - drug effects; Glycolysis; Glycolysis - drug effects; Humans; Immunology; Life Sciences; Metastases; Mice; Microenvironments; Pancreatic cancer; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Patients; Protein-Arginine N-Methyltransferases - genetics; Protein-Arginine N-Methyltransferases - metabolism; Tumor Microenvironment - drug effects; Tumors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism