IL5RA as an immunogenic cell death-related predictor in progression and therapeutic response of multiple myeloma

• Published in: Scientific reports Vol. 13; no. 1; pp. 8528 - 12
• Main Authors: Xu, Cong, Gao, Meng, Zhang, Junhua, Fu, Yunfeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.05.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 1-Phosphatidylinositol 3-kinase; 631/67/1857; 631/67/1990/804; AKT protein; Apoptosis; Cell death; Cell proliferation; Cytotoxicity; Drug resistance; Gene expression; Hippo Signaling Pathway; Humanities and Social Sciences; Humans; Immunogenic Cell Death; Immunogenicity; Interleukin-5 Receptor alpha Subunit - genetics; Mortality; multidisciplinary; Multiple myeloma; Multiple Myeloma - drug therapy; Multiple Myeloma - genetics; Multiple Myeloma - metabolism; N6-methyladenosine; Natural killer cells; Phosphatidylinositol 3-Kinases - metabolism; Science; Science (multidisciplinary); Signal transduction; Signal Transduction - genetics; Statistical analysis; Transfection

Previous studies have shown the potential of immunogenic cell death-related modalities in myeloma. The significance of IL5RA in myeloma and immunogenic cell death remains unknown. We analyzed IL5RA expression, the gene expression profile, and secretory protein genes related to IL5RA level using GEO...