Single-cell RNA sequencing explores the evolution of the ecosystem from leukoplakia to head and neck squamous cell carcinoma

• Published in: Scientific reports Vol. 14; no. 1; pp. 8097 - 11
• Main Authors: Wang, Haibin, Guan, Zhenjie, Zheng, Lian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1536; 631/67/1665; 692/699/3020/1665; Angiogenesis; CD163 antigen; CD1c antigen; Cell activation; Cell proliferation; Cell survival; Chemotaxis; Dendritic cells; Differentiation trajectory; Ecosystem evolution; Epithelial cells; Frizzled-related protein 1; Gene expression; Head & neck cancer; Head and neck carcinoma; Head and neck squamous cell carcinoma; Humanities and Social Sciences; Immune response; Inflammation; Leukocyte migration; Leukokeratosis; Leukoplakia; Lymphocytes T; Macrophages; Medical prognosis; Molecular modelling; multidisciplinary; Myeloid cells; Prognosis; Science; Science (multidisciplinary); Squamous cell carcinoma; Transcription activation; Head and neck squamous cell carcinoma; Differentiation trajectory; Prognosis; Leukoplakia; Ecosystem evolution

It has been found that progression from leukoplakia to head and neck squamous cell carcinoma (HNSCC) is a long-term process that may involve changes in the multicellular ecosystem. We acquired scRNA-seq samples information from gene expression omnibus and UCSC Xena database. The BEAM function was us...