Peripheral inflammatory biomarkers define biotypes of bipolar depression

• Published in: Molecular psychiatry Vol. 26; no. 7; pp. 3395 - 3406
• Main Authors: Lee, Yena, Mansur, Rodrigo B., Brietzke, Elisa, Kapogiannis, Dimitrios, Delgado-Peraza, Francheska, Boutilier, Justin J., Chan, Timothy C. Y., Carmona, Nicole E., Rosenblat, Joshua D., Lee, JungGoo, Maletic, Vladimir, Vinberg, Maj, Suppes, Trisha, Goldstein, Benjamin I., Ravindran, Arun V., Taylor, Valerie H., Chawla, Sahil, Nogueras-Ortiz, Carlos, Cosgrove, Victoria E., Kramer, Nicole E., Ho, Roger, Raison, Charles A., McIntyre, Roger S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2021; Nature Publishing Group
• Subjects: 13/21; 631/378; 692/53; 692/699/476/1333; 692/699/476/1414; 82/1; 82/79; Behavioral Sciences; Biological markers; Biological Psychology; Biomarkers; Biotypes; Bipolar disorder; Bipolar Disorder - drug therapy; c-Jun protein; Clinical trials; Diagnosis; Extracellular vesicles; FADD protein; Health aspects; Hedonic response; Humans; Inflammation; Infliximab; Infliximab - therapeutic use; Insulin; Insulin Receptor Substrate Proteins; JNK protein; Kinases; Learning algorithms; Machine learning; MAP kinase; MAP Kinase Signaling System; Medicine; Medicine & Public Health; Mental depression; Monoclonal antibodies; Neurosciences; NF-kappa B; NF-κB protein; Pharmacotherapy; Physiological aspects; Placebos; Protein kinase; Psychiatry; Psychological aspects; Transcription factors; Tumor necrosis factor receptors; Tumor Necrosis Factor-alpha; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Canada
• ISSN: 1359-4184; 1476-5578; 1476-5578
• DOI: 10.1038/s41380-021-01051-y

We identified biologically relevant moderators of response to tumor necrosis factor (TNF)-α inhibitor, infliximab, among 60 individuals with bipolar depression. Data were derived from a 12-week, randomized, placebo-controlled clinical trial secondarily evaluating the efficacy of infliximab on a meas...