Natural history of nonhuman primates after conjunctival exposure to Ebola virus

• Published in: Scientific reports Vol. 13; no. 1; pp. 4175 - 12
• Main Authors: Cross, Robert W., Prasad, Abhishek N., Woolsey, Courtney B., Agans, Krystle N., Borisevich, Viktoriya, Dobias, Natalie S., Comer, Jason E., Deer, Daniel J., Geisbert, Joan B., Rasmussen, Angela L., Lipkin, Walter Ian, Fenton, Karla A., Geisbert, Thomas W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/421; 631/326/596; Animals; Asymptomatic infection; Body fluids; Conjunctiva; Ebola virus; Ebolavirus; Hemorrhagic Fever, Ebola; Humanities and Social Sciences; Infections; Macaca fascicularis; multidisciplinary; Primates; Science; Science (multidisciplinary)

Transmission of Ebola virus (EBOV) primarily occurs via contact exposure of mucosal surfaces with infected body fluids. Historically, nonhuman primate (NHP) challenge studies have employed intramuscular (i.m.) or small particle aerosol exposure, which are largely lethal routes of infection, but mimi...