Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine

• Published in: Nature communications Vol. 15; no. 1; pp. 1284 - 14
• Main Authors: Halfmann, Peter J., Loeffler, Kathryn, Duffy, Augustine, Kuroda, Makoto, Yang, Jie E., Wright, Elizabeth R., Kawaoka, Yoshihiro, Kane, Ravi S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 101/28; 631/326/590/2294; 631/326/596/2078; 631/326/596/4130; 631/61/350; 82/80; ACE2; Angiotensin-Converting Enzyme 2; Animals; Antibodies; Antibodies, Neutralizing; Antibodies, Viral; Coronaviruses; COVID-19; Cricetinae; Evolution; Female; Females; Hamsters; Humanities and Social Sciences; Humans; Immunization; Lungs; multidisciplinary; Nanoparticles; Nanovaccines; Neutralizing; Proteins; Sarbecovirus; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Severe acute respiratory syndrome-related coronavirus; Spike protein; Vaccination; Vaccines; Viral diseases; Viruses

The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution of immune-evading SARS-CoV-2 variants together highlight the need for a broadly protective vaccine against ACE2-utilizing sarbecoviruses. While updated variant-matched formulations are a step in the right direction,...