The blood–brain barrier: Structure, regulation and drug delivery

• Published in: Signal transduction and targeted therapy Vol. 8; no. 1; pp. 217 - 27
• Main Authors: Wu, Di, Chen, Qi, Chen, Xiaojie, Han, Feng, Chen, Zhong, Wang, Yi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.05.2023; Nature Publishing Group
• Subjects: 631/154/152; 692/699/375; Biological Products - pharmacology; Biological Transport; Biopharmaceuticals; Blood-Brain Barrier; Brain; Cancer Research; Cell Biology; Central nervous system; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Drug therapy; Internal Medicine; Intranasal administration; Medicine; Medicine & Public Health; Membrane permeability; Oncology; Pathology; Permeability; Pharmaceutical Preparations; Review; Review Article

Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and biopharmaceuticals have been impeded to enter the br...