Establishment of a humanized mouse model of keloid diseases following the migration of patient immune cells to the lesion: Patient-derived keloid xenograft (PDKX) model

• Published in: Experimental & molecular medicine Vol. 55; no. 8; pp. 1713 - 1719
• Main Authors: Lee, A Ram, Lee, Seon-Yeong, Choi, Jeong Won, Um, In Gyu, Na, Hyun Sik, Lee, Jung Ho, Cho, Mi-La
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/107; 13/31; 13/51; 14/19; 38/77; 64/60; 692/308/1426; 692/420/2780/2152/1566/1618; 82/80; 96/21; Animal models; Biomedical and Life Sciences; Biomedicine; Chemokines; Helper cells; Hypoxia-inducible factor 1a; Immunodeficiency; Inflammation; Interleukin 17; Interleukin 2 receptors; Lesions; Leukocyte migration; Leukocytes (mononuclear); Lymphocytes T; Medical Biochemistry; Microenvironments; Molecular Medicine; Patients; Quality of life; Scars; Skin; Stem Cells; Transplantation; Xenografts

Keloid disorder is an abnormal fibroproliferative reaction that can occur on any area of skin, and it can impair the quality of life of affected individuals. To investigate the pathogenesis and develop a treatment strategy, a preclinical animal model of keloid disorder is needed. However, keloid dis...