Kappa opioid agonists reduce oxycodone self-administration in male rhesus monkeys

• Published in: Psychopharmacology Vol. 237; no. 5; pp. 1471 - 1480
• Main Authors: Zamarripa, C. Austin, Naylor, Jennifer E., Huskinson, Sally L., Townsend, E. Andrew, Prisinzano, Thomas E., Freeman, Kevin B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2020; Springer; Springer Nature B.V
• Subjects: Agonists; Analgesics; Analgesics, Opioid - administration & dosage; Animal experimentation; Animals; Behavior, Addictive - drug therapy; Behavior, Addictive - psychology; Biomedical and Life Sciences; Biomedicine; Central nervous system depressants; Cocaine; Cocaine - administration & dosage; Deterrents; Diterpenes, Clerodane - administration & dosage; Dose-Response Relationship, Drug; Drug self-administration; Experiments; Injection; Liability (Law); Macaca mulatta; Male; Morphinans - administration & dosage; Naltrexone - administration & dosage; Naltrexone - analogs & derivatives; Narcotic Antagonists - administration & dosage; Narcotics; Neurophysiology; Neurosciences; Opioid receptors (type kappa); Opioid receptors (type mu); Original Investigation; Oxycodone; Oxycodone - administration & dosage; Pharmacology/Toxicology; Psychiatry; Receptors, Opioid, kappa - agonists; Reinforcement, Psychology; Remifentanil; Salvinorin A; Self Administration; Spiro Compounds - administration & dosage; Punishment; Self-administration; Rhesus monkey; Oxycodone; Kappa opioid agonist

Rationale Combinations of mu and kappa opioid receptor (KOR) agonists have been proposed as potential analgesic formulations with reduced abuse liability. The current studies extend previous work by investigating the typical KOR agonist, salvinorin A, and the atypical KOR agonist, nalfurafine, as de...