Inflammatory stimuli induce shedding of heparan sulfate from arterial but not venous porcine endothelial cells leading to differential proinflammatory and procoagulant responses

• Published in: Scientific reports Vol. 13; no. 1; pp. 4483 - 14
• Main Authors: Milusev, Anastasia, Despont, Alain, Shaw, Jane, Rieben, Robert, Sorvillo, Nicoletta
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/2500; 631/250/2501; 631/250/256; 631/80; 631/80/221; Animals; Arteries - metabolism; Endothelial cells; Endothelial Cells - metabolism; Glycocalyx - metabolism; Heparan sulfate; Heparitin Sulfate - metabolism; Humanities and Social Sciences; Inflammatory diseases; Lipopolysaccharides; Microfluidics; multidisciplinary; Phenotypes; Science; Science (multidisciplinary); Sulfates; Swine; Veins - metabolism

Endothelial dysfunction is an early event of vascular injury defined by a proinflammatory and procoagulant endothelial cell (EC) phenotype. Although endothelial glycocalyx disruption is associated with vascular damage, how various inflammatory stimuli affect the glycocalyx and whether arterial and v...