Absence of Langerhans cells resulted in over-influx of neutrophils and increased bacterial burden in skin wounds

• Published in: Cell death & disease Vol. 15; no. 10; pp. 760 - 14
• Main Authors: Wang, Zheng-Cai, Hu, Yan-Yan, Shen, Xiao Z., Tan, Wei-Qiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.10.2024; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/1; 13/31; 14/19; 14/69; 631/250/2504/133/1593; 631/250/256/2516; Animals; Antibodies; Antigens; Bacteria; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Chemokine CXCL5 - metabolism; Chemokines; Dendritic cells; Epidermis; Humans; Immunology; Innate immunity; Keratinocytes; Keratinocytes - immunology; Keratinocytes - metabolism; Keratinocytes - microbiology; Langerhans cells; Langerhans Cells - immunology; Langerhans Cells - metabolism; Leukocytes (neutrophilic); Life Sciences; Mice; Mice, Inbred C57BL; Microorganisms; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; Progenitor cells; Propagation; Skin; Skin - immunology; Skin - microbiology; Skin - pathology; Wound Healing

Langerhans cells (LCs) are resident dendritic cells in the epidermis and their roles in presenting antigens derived from microorganisms present in the skin has been well appreciated. However, it is generally thought that incoming neutrophils are mainly responsible for eradicating invading pathogens...