A novel immune-related gene signature for diagnosis and potential immunotherapy of microsatellite stable endometrial carcinoma

• Published in: Scientific reports Vol. 14; no. 1; pp. 3738 - 13
• Main Authors: Xiao, Yunyun, Yu, XiaoChuan, Wang, Yaping, Song, Guangyao, Liu, Ming, Wang, Daqing, Wang, Huali
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/250; Aged; Carcinoma; Dendritic cells; Endometrial cancer; Endometrial Neoplasms - diagnosis; Endometrial Neoplasms - genetics; Endometrial Neoplasms - therapy; Endometrium; Female; Genes; Histology; Humanities and Social Sciences; Humans; Immune checkpoint inhibitors; Immunohistochemistry; Immunotherapy; Lymphocytes T; Macrophages; Microsatellite Instability; Microsatellite Repeats - genetics; mRNA; multidisciplinary; Oncogenes; Prognosis; Regression analysis; Risk Factors; Risk groups; Science; Science (multidisciplinary); Tumor suppressor genes; Tumors; Uterine cancer

An immune-related gene signature (IRGS) was established to better understand the molecular and immunologic characteristics of microsatellite instable (MSI) and microsatellite stable (MSS) endometrial carcinoma (EC), and provide potential immunotherapy directions for MSS patients. Top 20 immune-relat...