A Combined Metabonomic and Proteomic Approach Identifies Frontal Cortex Changes in a Chronic Phencyclidine Rat Model in Relation to Human Schizophrenia Brain Pathology

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 38; no. 12; pp. 2532 - 2544
• Main Authors: Wesseling, Hendrik, Chan, Man K, Tsang, T M, Ernst, Agnes, Peters, Fabian, Guest, Paul C, Holmes, Elaine, Bahn, Sabine
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.11.2013
• Subjects: Adult and adolescent clinical studies; Animals; Biological and medical sciences; Brain - pathology; Brain research; Chemical engineering; Disease; Disease Models, Animal; Drug dosages; Frontal Lobe - metabolism; Humans; Kinases; Magnetic Resonance Imaging; Male; Mass Spectrometry; Medical sciences; Metabolomics; NMR; Nuclear magnetic resonance; Original; Pathology; Phencyclidine; Proteomics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychosis; R&D; Rats; Rats, Sprague-Dawley; Research & development; Schizophrenia; Schizophrenia - chemically induced; Schizophrenia - metabolism; Schizophrenia - pathology; United Kingdom > UK; Calcium; Rat; Psychotropic; chronic phencyclidine rat model; Central nervous system; Schizophrenia; Glutamate receptor; Frontal cortex; Inorganic element; Encephalon; Psychosis; post-mortem brain; Phencyclidine; Anesthetic; Metabonomics; Piperidine derivatives; Hallucinogen; Drug of abuse; Antagonist; Human; H-NMR; Rodentia; Postmortem; calcium signaling; Neuroprotective agent; Nuclear magnetic resonance imaging; Vertebrata; Chronic; LC-MS; Mammalia; Animal; Proteomics; NMDA receptor

Current schizophrenia (SCZ) treatments fail to treat the broad range of manifestations associated with this devastating disorder. Thus, new translational models that reproduce the core pathological features are urgently needed to facilitate novel drug discovery efforts. Here, we report findings from...