Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

• Published in: Nature (London) Vol. 626; no. 7999; pp. 635 - 642
• Main Authors: Fan, Weiguo, Adebowale, Kolade, Váncza, Lóránd, Li, Yuan, Rabbi, Md Foysal, Kunimoto, Koshi, Chen, Dongning, Mozes, Gergely, Chiu, David Kung-Chun, Li, Yisi, Tao, Junyan, Wei, Yi, Adeniji, Nia, Brunsing, Ryan L., Dhanasekaran, Renumathy, Singhi, Aatur, Geller, David, Lo, Su Hao, Hodgson, Louis, Engleman, Edgar G., Charville, Gregory W., Charu, Vivek, Monga, Satdarshan P., Kim, Taeyoon, Wells, Rebecca G., Chaudhuri, Ovijit, Török, Natalie J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.02.2024; Nature Publishing Group
• Subjects: 13; 13/51; 13/95; 14; 38; 631/57; 631/67/1504/1610; 692/699/1503/1607/2751; 82; Advanced glycosylation end products; Age; Animal models; Animals; beta Catenin - metabolism; Carcinoma, Hepatocellular - complications; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Proliferation; Collagen; Collagen - chemistry; Collagen - metabolism; Computer Simulation; Connectivity; Cross-linking; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diet; Disease Progression; Elasticity; Energy dissipation; Extracellular matrix; Extracellular Matrix - metabolism; Glycation End Products, Advanced - metabolism; Hepatocellular carcinoma; Heterogeneity; Humanities and Social Sciences; Humans; Hydrogels; Integrin beta1 - metabolism; Liver cancer; Liver Cirrhosis - complications; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Neoplasms - complications; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Matrix methods; Mechanical properties; Microscopy; multidisciplinary; Neoplasm Invasiveness; Risk factors; Science; Science (multidisciplinary); Signal transduction; Stiffness; Stress relaxation; Tensin; Viscoelasticity; Viscosity; YAP-Signaling Proteins - metabolism; Yes-associated protein

Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1 , 2 , and increased stiffness is known to promote HCC progression in cirrhotic conditions 3 , 4 . Type 2 diabetes mellitus is charact...