Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1 , 2 , and increased stiffness is known to promote HCC progression in cirrhotic conditions 3 , 4 . Type 2 diabetes mellitus is charact...

Full description

Saved in:
Bibliographic Details
Published inNature (London) Vol. 626; no. 7999; pp. 635 - 642
Main Authors Fan, Weiguo, Adebowale, Kolade, Váncza, Lóránd, Li, Yuan, Rabbi, Md Foysal, Kunimoto, Koshi, Chen, Dongning, Mozes, Gergely, Chiu, David Kung-Chun, Li, Yisi, Tao, Junyan, Wei, Yi, Adeniji, Nia, Brunsing, Ryan L., Dhanasekaran, Renumathy, Singhi, Aatur, Geller, David, Lo, Su Hao, Hodgson, Louis, Engleman, Edgar G., Charville, Gregory W., Charu, Vivek, Monga, Satdarshan P., Kim, Taeyoon, Wells, Rebecca G., Chaudhuri, Ovijit, Török, Natalie J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.02.2024
Nature Publishing Group
Subjects
13
13/51
13/95
14
38
631/57
631/67/1504/1610
692/699/1503/1607/2751
82
Advanced glycosylation end products
Age
Animal models
Animals
beta Catenin - metabolism
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Proliferation
Collagen
Collagen - chemistry
Collagen - metabolism
Computer Simulation
Connectivity
Cross-linking
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diet
Disease Progression
Elasticity
Energy dissipation
Extracellular matrix
Extracellular Matrix - metabolism
Glycation End Products, Advanced - metabolism
Hepatocellular carcinoma
Heterogeneity
Humanities and Social Sciences
Humans
Hydrogels
Integrin beta1 - metabolism
Liver cancer
Liver Cirrhosis - complications
Liver Cirrhosis - metabolism
Liver Cirrhosis - pathology
Liver Neoplasms - complications
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Matrix methods
Mechanical properties
Microscopy
multidisciplinary
Neoplasm Invasiveness
Risk factors
Science
Science (multidisciplinary)
Signal transduction
Stiffness
Stress relaxation
Tensin
Viscoelasticity
Viscosity
YAP-Signaling Proteins - metabolism
Yes-associated protein
Online AccessGet full text

Cover

Abstract Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1 , 2 , and increased stiffness is known to promote HCC progression in cirrhotic conditions 3 , 4 . Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High AGEs and viscoelasticity combined with oncogenic β-catenin signalling promote HCC induction, whereas inhibiting AGE production, reconstituting the AGE clearance receptor AGER1 or breaking AGE-mediated collagen cross-links reduces viscoelasticity and HCC growth. Matrix analysis and computational modelling demonstrate that lower interconnectivity of AGE-bundled collagen matrix, marked by shorter fibre length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through an integrin-β1–tensin-1–YAP mechanotransductive pathway. These results reveal that AGE-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness. Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
AbstractList Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1 , 2 , and increased stiffness is known to promote HCC progression in cirrhotic conditions 3 , 4 . Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High AGEs and viscoelasticity combined with oncogenic β-catenin signalling promote HCC induction, whereas inhibiting AGE production, reconstituting the AGE clearance receptor AGER1 or breaking AGE-mediated collagen cross-links reduces viscoelasticity and HCC growth. Matrix analysis and computational modelling demonstrate that lower interconnectivity of AGE-bundled collagen matrix, marked by shorter fibre length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through an integrin-β1–tensin-1–YAP mechanotransductive pathway. These results reveal that AGE-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness. Structural changes mediated by advanced glycation end-products enhance extracellular matrix viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development , and increased stiffness is known to promote HCC progression in cirrhotic conditions . Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High AGEs and viscoelasticity combined with oncogenic β-catenin signalling promote HCC induction, whereas inhibiting AGE production, reconstituting the AGE clearance receptor AGER1 or breaking AGE-mediated collagen cross-links reduces viscoelasticity and HCC growth. Matrix analysis and computational modelling demonstrate that lower interconnectivity of AGE-bundled collagen matrix, marked by shorter fibre length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through an integrin-β1-tensin-1-YAP mechanotransductive pathway. These results reveal that AGE-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development 1,2 , and increased stiffness is known to promote HCC progression in cirrhotic conditions 3,4 . Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High AGEs and viscoelasticity combined with oncogenic β-catenin signalling promote HCC induction, whereas inhibiting AGE production, reconstituting the AGE clearance receptor AGER1 or breaking AGE-mediated collagen cross-links reduces viscoelasticity and HCC growth. Matrix analysis and computational modelling demonstrate that lower interconnectivity of AGE-bundled collagen matrix, marked by shorter fibre length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through an integrin-β1–tensin-1–YAP mechanotransductive pathway. These results reveal that AGE-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development1-2, and increased stiffness is known to promote HCC progression in cirrhotic conditions3-4. Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (ACEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, ACEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High ACEs and viscoelasticity combined with oncogenic ß-catenin signalling promote HCC induction, whereas inhibiting AGE production, reconstituting the AGE clearance receptor AGERI or breaking AGE-mediated collagen cross-links reduces viscoelasticity and HCC growth. Matrix analysis and computational modelling demonstrate that lower interconnectivity of AGE-bundled collagen matrix, marked by shorter fibre length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through an integrin-ßl-tensin-1-YAP mechanotransductive pathway. These results reveal that AGE-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development1,2, and increased stiffness is known to promote HCC progression in cirrhotic conditions3,4. Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High AGEs and viscoelasticity combined with oncogenic β-catenin signalling promote HCC induction, whereas inhibiting AGE production, reconstituting the AGE clearance receptor AGER1 or breaking AGE-mediated collagen cross-links reduces viscoelasticity and HCC growth. Matrix analysis and computational modelling demonstrate that lower interconnectivity of AGE-bundled collagen matrix, marked by shorter fibre length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through an integrin-β1-tensin-1-YAP mechanotransductive pathway. These results reveal that AGE-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer development1,2, and increased stiffness is known to promote HCC progression in cirrhotic conditions3,4. Type 2 diabetes mellitus is characterized by an accumulation of advanced glycation end-products (AGEs) in the ECM; however, how this affects HCC in non-cirrhotic conditions is unclear. Here we find that, in patients and animal models, AGEs promote changes in collagen architecture and enhance ECM viscoelasticity, with greater viscous dissipation and faster stress relaxation, but not changes in stiffness. High AGEs and viscoelasticity combined with oncogenic β-catenin signalling promote HCC induction, whereas inhibiting AGE production, reconstituting the AGE clearance receptor AGER1 or breaking AGE-mediated collagen cross-links reduces viscoelasticity and HCC growth. Matrix analysis and computational modelling demonstrate that lower interconnectivity of AGE-bundled collagen matrix, marked by shorter fibre length and greater heterogeneity, enhances viscoelasticity. Mechanistically, animal studies and 3D cell cultures show that enhanced viscoelasticity promotes HCC cell proliferation and invasion through an integrin-β1-tensin-1-YAP mechanotransductive pathway. These results reveal that AGE-mediated structural changes enhance ECM viscoelasticity, and that viscoelasticity can promote cancer progression in vivo, independent of stiffness.
Author Chaudhuri, Ovijit
Török, Natalie J.
Váncza, Lóránd
Charville, Gregory W.
Dhanasekaran, Renumathy
Kim, Taeyoon
Chiu, David Kung-Chun
Engleman, Edgar G.
Hodgson, Louis
Monga, Satdarshan P.
Wells, Rebecca G.
Geller, David
Adeniji, Nia
Li, Yisi
Adebowale, Kolade
Rabbi, Md Foysal
Tao, Junyan
Brunsing, Ryan L.
Wei, Yi
Singhi, Aatur
Charu, Vivek
Li, Yuan
Kunimoto, Koshi
Fan, Weiguo
Lo, Su Hao
Chen, Dongning
Mozes, Gergely
Author_xml – sequence: 1
  givenname: Weiguo
  surname: Fan
  fullname: Fan, Weiguo
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 2
  givenname: Kolade
  surname: Adebowale
  fullname: Adebowale, Kolade
  organization: Department of Chemical Engineering, Stanford University, Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University
– sequence: 3
  givenname: Lóránd
  orcidid: 0000-0003-0295-4732
  surname: Váncza
  fullname: Váncza, Lóránd
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 4
  givenname: Yuan
  surname: Li
  fullname: Li, Yuan
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 5
  givenname: Md Foysal
  orcidid: 0000-0003-3214-2209
  surname: Rabbi
  fullname: Rabbi, Md Foysal
  organization: Weldon School of Biomedical Engineering, Purdue University
– sequence: 6
  givenname: Koshi
  surname: Kunimoto
  fullname: Kunimoto, Koshi
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 7
  givenname: Dongning
  surname: Chen
  fullname: Chen, Dongning
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 8
  givenname: Gergely
  surname: Mozes
  fullname: Mozes, Gergely
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 9
  givenname: David Kung-Chun
  surname: Chiu
  fullname: Chiu, David Kung-Chun
  organization: Department of Pathology, Stanford University, Division of Immunology, Stanford University
– sequence: 10
  givenname: Yisi
  surname: Li
  fullname: Li, Yisi
  organization: Department of Automation, Tsinghua University
– sequence: 11
  givenname: Junyan
  surname: Tao
  fullname: Tao, Junyan
  organization: Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center
– sequence: 12
  givenname: Yi
  surname: Wei
  fullname: Wei, Yi
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 13
  givenname: Nia
  surname: Adeniji
  fullname: Adeniji, Nia
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 14
  givenname: Ryan L.
  surname: Brunsing
  fullname: Brunsing, Ryan L.
  organization: Department of Radiology, Stanford University
– sequence: 15
  givenname: Renumathy
  surname: Dhanasekaran
  fullname: Dhanasekaran, Renumathy
  organization: Gastroenterology and Hepatology, Stanford University, VA
– sequence: 16
  givenname: Aatur
  orcidid: 0000-0003-3930-7096
  surname: Singhi
  fullname: Singhi, Aatur
  organization: Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center
– sequence: 17
  givenname: David
  surname: Geller
  fullname: Geller, David
  organization: Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center
– sequence: 18
  givenname: Su Hao
  surname: Lo
  fullname: Lo, Su Hao
  organization: Department of Biochemistry and Molecular Medicine, University of California at Davis
– sequence: 19
  givenname: Louis
  orcidid: 0000-0001-9188-7580
  surname: Hodgson
  fullname: Hodgson, Louis
  organization: Department of Molecular Pharmacology, Albert Einstein College of Medicine
– sequence: 20
  givenname: Edgar G.
  surname: Engleman
  fullname: Engleman, Edgar G.
  organization: Department of Pathology, Stanford University, Division of Immunology, Stanford University
– sequence: 21
  givenname: Gregory W.
  orcidid: 0000-0002-2774-2704
  surname: Charville
  fullname: Charville, Gregory W.
  organization: Department of Pathology, Stanford University
– sequence: 22
  givenname: Vivek
  surname: Charu
  fullname: Charu, Vivek
  organization: Department of Pathology, Stanford University, Quantitative Sciences Unit, Department of Medicine, Stanford University School of Medicine
– sequence: 23
  givenname: Satdarshan P.
  orcidid: 0000-0002-8437-3378
  surname: Monga
  fullname: Monga, Satdarshan P.
  organization: Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center
– sequence: 24
  givenname: Taeyoon
  surname: Kim
  fullname: Kim, Taeyoon
  organization: Weldon School of Biomedical Engineering, Purdue University, Faculty of Science and Technology, Keio University
– sequence: 25
  givenname: Rebecca G.
  orcidid: 0000-0002-6988-4102
  surname: Wells
  fullname: Wells, Rebecca G.
  organization: Departments of Medicine and Bioengineering, University of Pennsylvania
– sequence: 26
  givenname: Ovijit
  orcidid: 0000-0002-9287-3401
  surname: Chaudhuri
  fullname: Chaudhuri, Ovijit
  organization: Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Department of Mechanical Engineering, Stanford University
– sequence: 27
  givenname: Natalie J.
  orcidid: 0000-0001-8074-7048
  surname: Török
  fullname: Török, Natalie J.
  email: ntorok@stanford.edu
  organization: Gastroenterology and Hepatology, Stanford University, VA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38297127$$D View this record in MEDLINE/PubMed
BookMark eNp9kTtPHDEUha2IKCwkf4ACjURD48SP8atCCBESiShFktry2J5do1l7sb0r-PcxDORBQXWl6-9cHZ9zAPZiih6AI4w-YkTlp9JjJjlEhELElcJQvQEL3AsOey7FHlggRCREkvJ9cFDKDUKIYdG_A_tUEiUwEQvw45upOdx1u1Bs8pMpNdhQ77tNTutUfemmsPO5sybaNtp2mX0pIcUuxK6ufFt5aEPOq9SUM_0evB3NVPyHp3kIfn2-_HnxBV5_v_p6cX4NLetxhdxwbARRg-GKKcuoVcIRyp0bhfWOCoWUVNIwRJzyGBknBzTigQ9idMJxegjO5rub7bD2zvpYs5n0Joe1yfc6maD_f4lhpZdppzGSnAvUtwunTxdyut36UvW65eCnyUSftkUTRTDGjFPW0JMX6E3a5tj-90BJyjAXtFHH_1r64-U58AbIGbA5lZL9qFvcprZAm8MwNWv6oVs9d6tbt_qxW62alLyQPl9_VURnUWlwXPr81_Yrqt8u6rg4
CitedBy_id crossref_primary_10_1016_j_cobme_2024_100570
crossref_primary_10_1016_j_biomaterials_2025_123266
crossref_primary_10_1021_acsnano_4c02987
crossref_primary_10_1007_s12272_024_01501_5
crossref_primary_10_1039_D4BM00358F
crossref_primary_10_3389_fcell_2025_1564626
crossref_primary_10_3892_ijo_2024_5676
crossref_primary_10_1016_j_cclet_2024_110715
crossref_primary_10_1016_j_bpj_2024_05_033
crossref_primary_10_1016_j_plrev_2025_02_004
crossref_primary_10_1002_cbin_12156
crossref_primary_10_1002_adhm_202401550
crossref_primary_10_1097_HC9_0000000000000569
crossref_primary_10_1186_s13046_025_03297_8
crossref_primary_10_1097_HC9_0000000000000489
crossref_primary_10_1038_s41568_024_00678_7
crossref_primary_10_1038_s41420_024_01972_x
crossref_primary_10_1002_cbf_4126
crossref_primary_10_1016_j_cej_2024_157483
crossref_primary_10_3390_ijms25073816
crossref_primary_10_1002_advs_202403040
crossref_primary_10_1007_s10237_024_01909_4
crossref_primary_10_1073_pnas_2416771122
crossref_primary_10_1016_j_gene_2025_149271
crossref_primary_10_1142_S1758825124500820
crossref_primary_10_1186_s10020_025_01131_7
crossref_primary_10_1186_s40164_024_00591_7
crossref_primary_10_1186_s40364_025_00727_9
crossref_primary_10_1021_cbe_4c00129
crossref_primary_10_1136_jitc_2024_010029
crossref_primary_10_1016_j_aca_2024_342802
crossref_primary_10_1002_adma_202407661
crossref_primary_10_1142_S1793545825300046
crossref_primary_10_1002_adma_202404235
crossref_primary_10_1002_adfm_202420158
crossref_primary_10_1039_D4TC03715D
crossref_primary_10_1007_s00253_024_13211_5
crossref_primary_10_1002_adhm_202405097
crossref_primary_10_1016_j_colsurfb_2024_114435
crossref_primary_10_2147_JHC_S488061
crossref_primary_10_3390_jcm14061856
crossref_primary_10_1038_s41392_024_01848_7
crossref_primary_10_1186_s13071_025_06689_z
crossref_primary_10_1016_j_pnmrs_2024_05_002
crossref_primary_10_1073_pnas_2410806121
crossref_primary_10_1055_a_2289_2298
crossref_primary_10_1016_j_trecan_2024_07_003
crossref_primary_10_1016_j_jep_2024_118516
crossref_primary_10_1007_s00204_024_03941_w
crossref_primary_10_1038_s41568_024_00745_z
crossref_primary_10_1088_1758_5090_ad5705
crossref_primary_10_3390_biom15010096
crossref_primary_10_1111_nyas_15184
crossref_primary_10_1111_cns_70283
crossref_primary_10_3724_abbs_2024191
crossref_primary_10_1016_j_biomaterials_2025_123209
crossref_primary_10_1016_j_pharmr_2024_100031
crossref_primary_10_1021_acsami_4c18174
crossref_primary_10_1016_j_eng_2025_01_018
crossref_primary_10_1016_j_mtbio_2024_101245
Cites_doi 10.1002/hep.24108
10.1016/j.cmet.2018.10.012
10.1073/pnas.1523906113
10.1002/hep.28601
10.1074/jbc.M111.282442
10.1074/jbc.M109.059592
10.1038/cdd.2017.99
10.1007/s00125-015-3523-x
10.1038/s41568-020-00329-7
10.1002/hep.30333
10.1038/s41563-022-01400-4
10.1016/j.bpj.2017.11.3739
10.1038/s41467-018-06641-z
10.1016/j.gene.2012.07.009
10.1038/s41467-019-08465-x
10.1111/boc.201600053
10.1074/jbc.RA118.004829
10.1016/j.bbcan.2020.188356
10.2337/db11-0291
10.1196/annals.1333.080
10.1016/j.bbamcr.2015.09.028
10.1371/journal.pone.0035143
10.1038/s41467-018-02906-9
10.1016/j.matbio.2016.09.001
10.1364/BOE.10.001841
10.1172/JCI93554
10.1016/j.actbio.2017.11.037
10.1016/j.mri.2004.11.060
10.1186/s12916-020-01797-2
10.1002/hep.32244
10.1039/C9BM00184K
10.1007/s001250051437
10.1038/nmat4489
10.1073/pnas.1222787110
10.1016/j.metabol.2008.05.018
10.1016/j.jhep.2009.12.007
10.1126/sciadv.aaw6171
10.1186/s12902-019-0444-6
10.1053/j.gastro.2015.04.009
10.1055/s-0042-100910
10.1111/liv.14362
10.1371/journal.pone.0146588
10.1038/s41586-020-2612-2
10.1002/prot.24560
10.1097/HJH.0b013e328013e7dd
10.2337/db16-1477
10.1038/ncb3336
10.1136/bmj.g7607
10.1126/science.1170107
10.1002/hep.31288
10.1016/j.cell.2009.10.027
10.1016/j.ajpath.2019.01.016
10.1038/s41551-023-01019-z
10.1038/s41563-021-00981-w
10.3390/polym13162642
ContentType Journal Article
Copyright This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024
2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Copyright Nature Publishing Group Feb 15, 2024
Copyright_xml – notice: This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2024
– notice: 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
– notice: Copyright Nature Publishing Group Feb 15, 2024
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QG
7QL
7QP
7QR
7RV
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7X2
7X7
7XB
88A
88E
88G
88I
8AF
8AO
8C1
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
8G5
ABJCF
ABUWG
AEUYN
AFKRA
ARAPS
ATCPS
AZQEC
BBNVY
BEC
BENPR
BGLVJ
BHPHI
BKSAR
C1K
CCPQU
D1I
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
KB.
KB0
KL.
L6V
LK8
M0K
M0S
M1P
M2M
M2O
M2P
M7N
M7P
M7S
MBDVC
NAPCQ
P5Z
P62
P64
PATMY
PCBAR
PDBOC
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
PSYQQ
PTHSS
PYCSY
Q9U
R05
RC3
S0X
SOI
7X8
5PM
DOI 10.1038/s41586-023-06991-9
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Animal Behavior Abstracts
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Nursing & allied health premium.
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Meteorological & Geoastrophysical Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Virology and AIDS Abstracts
Agricultural Science Collection
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
Psychology Database (Alumni)
Science Database (Alumni Edition)
STEM Database
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
Materials Science & Engineering Collection
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
Agricultural & Environmental Science Collection
ProQuest Central Essentials
Biological Science Collection
eLibrary
ProQuest Central
Technology Collection
Natural Science Collection
Earth, Atmospheric & Aquatic Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Materials Science Collection
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Materials Science Database
Nursing & Allied Health Database (Alumni Edition)
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest Engineering Collection
Biological Sciences
Agricultural Science Database
ProQuest Health & Medical Collection
Medical Database
Psychology Database
Research Library
Science Database
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Engineering Database
Research Library (Corporate)
Nursing & Allied Health Premium
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
Environmental Science Database
Earth, Atmospheric & Aquatic Science Database
Materials Science Collection
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest One Psychology
Engineering Collection
Environmental Science Collection
ProQuest Central Basic
University of Michigan
Genetics Abstracts
SIRS Editorial
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Agricultural Science Database
ProQuest One Psychology
Research Library Prep
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
elibrary
ProQuest AP Science
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Meteorological & Geoastrophysical Abstracts
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Engineering Collection
Advanced Technologies & Aerospace Collection
Engineering Database
Virology and AIDS Abstracts
ProQuest Science Journals (Alumni Edition)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Earth, Atmospheric & Aquatic Science Database
Agricultural Science Collection
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Environmental Science Collection
Entomology Abstracts
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Environmental Science Database
ProQuest Nursing & Allied Health Source (Alumni)
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
Meteorological & Geoastrophysical Abstracts - Academic
ProQuest One Academic (New)
University of Michigan
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
SIRS Editorial
Materials Science Collection
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
Earth, Atmospheric & Aquatic Science Collection
ProQuest Health & Medical Research Collection
Genetics Abstracts
ProQuest Engineering Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Agricultural & Environmental Science Collection
AIDS and Cancer Research Abstracts
Materials Science Database
ProQuest Research Library
ProQuest Materials Science Collection
ProQuest Public Health
ProQuest Central Basic
ProQuest Science Journals
ProQuest Nursing & Allied Health Source
ProQuest Psychology Journals (Alumni)
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
ProQuest Psychology Journals
Animal Behavior Abstracts
Materials Science & Engineering Collection
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
CrossRef
Agricultural Science Database
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Sciences (General)
Physics
EISSN 1476-4687
EndPage 642
ExternalDocumentID PMC10866704
38297127
10_1038_s41586_023_06991_9
Genre Journal Article
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: R01 CA250227
– fundername: BLRD VA
  grantid: I01 BX002418
– fundername: NIDDK NIH HHS
  grantid: P30 DK120531
– fundername: NIDDK NIH HHS
  grantid: R01 DK083283
– fundername: NIDDK NIH HHS
  grantid: P30 DK116074
– fundername: NCI NIH HHS
  grantid: R37 CA214136
– fundername: NCI NIH HHS
  grantid: R01 CA204586
– fundername: NIDDK NIH HHS
  grantid: R01 DK062277
– fundername: NIA NIH HHS
  grantid: R01 AG060726
– fundername: NCI NIH HHS
  grantid: P30 CA124435
GroupedDBID ---
--Z
-DZ
-ET
-~X
.55
.CO
.XZ
07C
0R~
123
186
1OL
29M
2KS
39C
53G
5RE
6TJ
70F
7RV
85S
8WZ
97F
A6W
A7Z
AAEEF
AAHBH
AAHTB
AAIKC
AAKAB
AAMNW
AASDW
AAYEP
AAYZH
AAZLF
ABDQB
ABFSI
ABIVO
ABJNI
ABLJU
ABOCM
ABPEJ
ABPPZ
ABWJO
ABZEH
ACBEA
ACBWK
ACGFO
ACGFS
ACGOD
ACIWK
ACKOT
ACMJI
ACNCT
ACPRK
ACWUS
ADBBV
ADFRT
ADUKH
AENEX
AFBBN
AFFNX
AFLOW
AFRAH
AFSHS
AGAYW
AGHSJ
AGHTU
AGOIJ
AGSOS
AHMBA
AHSBF
AIDUJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
ARAPS
ARMCB
ASPBG
ATCPS
ATWCN
AVWKF
AXYYD
AZFZN
BENPR
BHPHI
BIN
BKKNO
C6C
CJ0
CS3
DU5
E.-
E.L
EAP
EBS
EE.
EMH
EPS
EXGXG
F5P
FAC
FEDTE
FQGFK
FSGXE
HCIFZ
HG6
HVGLF
HZ~
IAO
ICQ
IEA
IEP
IGS
IH2
IHR
INH
IOF
IPY
KOO
L7B
LGEZI
LOTEE
LSO
M0K
M2O
M7P
N9A
NADUK
NEPJS
NXXTH
O9-
OBC
ODYON
OES
OHH
OMK
OVD
P2P
PKN
PV9
RND
RNS
RNT
RNTTT
RXW
SC5
SHXYY
SIXXV
SJN
SNYQT
SOJ
TAE
TAOOD
TBHMF
TDRGL
TEORI
TN5
TSG
TWZ
U5U
UIG
UKR
UMD
UQL
VQA
VVN
WH7
X7M
XIH
XKW
XZL
Y6R
YAE
YCJ
YFH
YIF
YIN
YJ6
YNT
YOC
YQT
YR2
YR5
YXB
YZZ
Z5M
ZCA
~02
~88
~KM
1VR
2XV
41X
7X2
7X7
7XC
88E
88I
8AF
8AO
8C1
8CJ
8FE
8FG
8FH
8FI
8FJ
8G5
8R4
8R5
97L
AARCD
AAYXX
ABFSG
ABJCF
ABUWG
ACMFV
ACSTC
AEUYN
AEZWR
AFANA
AFHIU
AFKRA
AHWEU
AIXLP
ALPWD
ATHPR
AZQEC
BBNVY
BCU
BEC
BGLVJ
BKEYQ
BKSAR
BPHCQ
BVXVI
CCPQU
CITATION
D1I
D1J
D1K
DWQXO
EX3
FYUFA
GNUQQ
GUQSH
HMCUK
INR
ISR
K6-
KB.
L6V
LK5
LK8
M1P
M2M
M2P
M7R
M7S
NAPCQ
NFIDA
P62
PATMY
PCBAR
PDBOC
PHGZM
PHGZT
PQQKQ
PROAC
PSQYO
PSYQQ
PTHSS
PYCSY
Q2X
R05
S0X
SJFOW
UKHRP
WOW
~7V
.-4
.GJ
.HR
00M
08P
0WA
1CY
1VW
354
3EH
3O-
4.4
41~
42X
4R4
663
79B
9M8
A8Z
AAJYS
AAKAS
AAVBQ
ABAWZ
ABDBF
ABDPE
ABEFU
ABNNU
ACBNA
ACBTR
ACRPL
ACTDY
ACUHS
ADGHP
ADNMO
ADRHT
ADXHL
ADYSU
ADZCM
AETEA
AFFDN
AFHKK
AGCDD
AGGDT
AGNAY
AGQPQ
AIDAL
AIYXT
AJUXI
APEBS
ARTTT
B0M
BCR
BDKGC
BES
BKOMP
BLC
CGR
CUY
CVF
DB5
DO4
EAD
EAS
EAZ
EBC
EBD
EBO
ECC
ECM
EIF
EJD
EMB
EMF
EMK
EMOBN
EPL
ESE
ESN
ESX
FA8
I-F
ITC
J5H
L-9
MVM
N4W
NEJ
NPM
OHT
P-O
PEA
PJZUB
PM3
PPXIY
PQGLB
QS-
R4F
RHI
SKT
SV3
TH9
TUD
TUS
UBY
UHB
USG
VOH
X7L
XOL
YQI
YQJ
YV5
YXA
YYP
YYQ
ZCG
ZE2
ZGI
ZHY
ZKB
ZY4
~8M
~G0
3V.
7QG
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7TG
7TK
7TM
7TO
7U9
7XB
88A
8FD
8FK
AFKWF
C1K
FR3
H94
K9.
KL.
M7N
MBDVC
P64
PKEHL
PQEST
PQUKI
PRINS
PUEGO
Q9U
RC3
SOI
7X8
5PM
ID FETCH-LOGICAL-c541t-6a61a729ba6959c53c97d236ddf7ced37909898a502d9e10ad8b0f1b6b7fd7d63
IEDL.DBID 8FG
ISSN 0028-0836
1476-4687
IngestDate Thu Aug 21 18:35:09 EDT 2025
Wed Jul 30 11:09:54 EDT 2025
Sat Aug 23 14:48:14 EDT 2025
Mon Jul 21 05:55:24 EDT 2025
Thu Apr 24 22:50:53 EDT 2025
Tue Jul 01 02:58:51 EDT 2025
Fri Feb 21 02:39:32 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 7999
Language English
License 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c541t-6a61a729ba6959c53c97d236ddf7ced37909898a502d9e10ad8b0f1b6b7fd7d63
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0003-3930-7096
0000-0002-2774-2704
0000-0002-8437-3378
0000-0002-6988-4102
0000-0001-8074-7048
0000-0002-9287-3401
0000-0001-9188-7580
0000-0003-0295-4732
0000-0003-3214-2209
OpenAccessLink https://www.nature.com/articles/s41586-023-06991-9
PMID 38297127
PQID 2928351673
PQPubID 40569
PageCount 8
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_10866704
proquest_miscellaneous_2921115635
proquest_journals_2928351673
pubmed_primary_38297127
crossref_citationtrail_10_1038_s41586_023_06991_9
crossref_primary_10_1038_s41586_023_06991_9
springer_journals_10_1038_s41586_023_06991_9
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2024-02-15
PublicationDateYYYYMMDD 2024-02-15
PublicationDate_xml – month: 02
  year: 2024
  text: 2024-02-15
  day: 15
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationSubtitle International weekly journal of science
PublicationTitle Nature (London)
PublicationTitleAbbrev Nature
PublicationTitleAlternate Nature
PublicationYear 2024
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Wojciechowska, Krajewski, Bolanowski, Krecicki, Zatonski (CR39) 2016; 124
Yan, Yan, Ou (CR50) 2012; 506
Elosegui-Artola (CR32) 2016; 18
Shih, Sun, Wang, Lo (CR34) 2015; 1853
Andriotis (CR11) 2019; 10
Levental (CR42) 2009; 139
Dehnad (CR10) 2020; 130
Joo (CR28) 2020; 43
Furth, Aylon (CR35) 2017; 24
Engler, Humbert, Wehrle-Haller, Weaver (CR33) 2009; 324
Negro (CR5) 2020; 40
Rubiano (CR45) 2018; 67
Lee, Stowers, Chaudhuri (CR47) 2019; 10
Muellenbach (CR51) 2008; 57
Elosegui-Artola (CR17) 2023; 22
Bettaieb (CR56) 2015; 149
CR44
Hudson, Archer, King, Eyre (CR24) 2018; 293
CR43
McVicar (CR8) 2015; 58
Farrell (CR18) 2019; 69
Gautieri (CR22) 2017; 59
Henning, Smuda, Girndt, Ulrich, Glomb (CR7) 2011; 286
Charrier, Pogoda, Wells, Janmey (CR14) 2018; 9
Escala-Garcia (CR36) 2020; 18
Sinkus (CR46) 2005; 23
Ban (CR25) 2018; 114
Piersma, Hayward, Weaver (CR2) 2020; 1873
Wisdom (CR16) 2018; 9
Kramer (CR6) 2022; 75
Hall, Daugherty, Choi, Horwitz, Brautigan (CR31) 2009; 284
Nam (CR15) 2019; 5
Andersen (CR40) 2017; 66
CR13
Chaudhuri (CR48) 2016; 15
Zhang (CR54) 2019; 189
Patel (CR49) 2012; 7
Schrader (CR3) 2011; 53
Ulrich, Zhang (CR53) 1997; 40
Guimaraes, Empsen, Geerts, van Grunsven (CR58) 2010; 52
Cox (CR1) 2021; 21
Chaudhuri, Cooper-White, Janmey, Mooney, Shenoy (CR12) 2020; 584
Colhoun (CR9) 2011; 60
Blangy (CR29) 2017; 109
Soltani (CR37) 2019; 19
Nam, Hu, Butte, Chaudhuri (CR27) 2016; 113
Munster (CR26) 2013; 110
Unno (CR57) 2005; 1043
Yamauchi, Barker, Gibbons, Kurie (CR41) 2018; 128
Tao (CR20) 2016; 64
Haynie (CR30) 2014; 82
CR21
Tsilidis, Kasimis, Lopez, Ntzani, Ioannidis (CR38) 2015; 350
McGlynn, Petrick, El-Serag (CR4) 2021; 73
Perepelyuk (CR55) 2016; 11
Zieman (CR52) 2007; 25
Febbraio (CR19) 2019; 29
Dandia, Makkad, Tayalia (CR23) 2019; 7
AJ Engler (6991_CR33) 2009; 324
G Soltani (6991_CR37) 2019; 19
HP Lee (6991_CR47) 2019; 10
S Nam (6991_CR27) 2016; 113
J Zhang (6991_CR54) 2019; 189
DT Haynie (6991_CR30) 2014; 82
MA Febbraio (6991_CR19) 2019; 29
Z Yan (6991_CR50) 2012; 506
A Blangy (6991_CR29) 2017; 109
EE Charrier (6991_CR14) 2018; 9
M Perepelyuk (6991_CR55) 2016; 11
M Yamauchi (6991_CR41) 2018; 128
G Farrell (6991_CR18) 2019; 69
KR Levental (6991_CR42) 2009; 139
6991_CR44
6991_CR43
E Ban (6991_CR25) 2018; 114
O Chaudhuri (6991_CR48) 2016; 15
HM Colhoun (6991_CR9) 2011; 60
EA Muellenbach (6991_CR51) 2008; 57
J Wojciechowska (6991_CR39) 2016; 124
6991_CR13
F Negro (6991_CR5) 2020; 40
A Rubiano (6991_CR45) 2018; 67
Y Unno (6991_CR57) 2005; 1043
KM Wisdom (6991_CR16) 2018; 9
R Patel (6991_CR49) 2012; 7
J Tao (6991_CR20) 2016; 64
A Elosegui-Artola (6991_CR32) 2016; 18
M Escala-Garcia (6991_CR36) 2020; 18
DK Andersen (6991_CR40) 2017; 66
B Piersma (6991_CR2) 2020; 1873
KA McGlynn (6991_CR4) 2021; 73
S Munster (6991_CR26) 2013; 110
A Dehnad (6991_CR10) 2020; 130
P Ulrich (6991_CR53) 1997; 40
TR Cox (6991_CR1) 2021; 21
JR Kramer (6991_CR6) 2022; 75
C Henning (6991_CR7) 2011; 286
J Schrader (6991_CR3) 2011; 53
O Chaudhuri (6991_CR12) 2020; 584
CM McVicar (6991_CR8) 2015; 58
N Furth (6991_CR35) 2017; 24
JS Joo (6991_CR28) 2020; 43
SJ Zieman (6991_CR52) 2007; 25
A Bettaieb (6991_CR56) 2015; 149
6991_CR21
YP Shih (6991_CR34) 2015; 1853
A Gautieri (6991_CR22) 2017; 59
H Dandia (6991_CR23) 2019; 7
EL Guimaraes (6991_CR58) 2010; 52
S Nam (6991_CR15) 2019; 5
EH Hall (6991_CR31) 2009; 284
A Elosegui-Artola (6991_CR17) 2023; 22
DM Hudson (6991_CR24) 2018; 293
R Sinkus (6991_CR46) 2005; 23
KK Tsilidis (6991_CR38) 2015; 350
OG Andriotis (6991_CR11) 2019; 10
References_xml – volume: 53
  start-page: 1192
  year: 2011
  end-page: 1205
  ident: CR3
  article-title: Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
  publication-title: Hepatology
  doi: 10.1002/hep.24108
– volume: 29
  start-page: 18
  year: 2019
  end-page: 26
  ident: CR19
  article-title: Preclinical models for studying NASH-driven HCC: how useful are they?
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2018.10.012
– volume: 113
  start-page: 5492
  year: 2016
  end-page: 5497
  ident: CR27
  article-title: Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1523906113
– volume: 64
  start-page: 1587
  year: 2016
  end-page: 1605
  ident: CR20
  article-title: Modeling a human hepatocellular carcinoma subset in mice through coexpression of met and point-mutant β-catenin
  publication-title: Hepatology
  doi: 10.1002/hep.28601
– volume: 286
  start-page: 44350
  year: 2011
  end-page: 44356
  ident: CR7
  article-title: Molecular basis of maillard amide-advanced glycation end product (AGE) formation in vivo
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.282442
– volume: 284
  start-page: 34713
  year: 2009
  end-page: 34722
  ident: CR31
  article-title: Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.059592
– volume: 24
  start-page: 1488
  year: 2017
  end-page: 1501
  ident: CR35
  article-title: The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2017.99
– volume: 58
  start-page: 1129
  year: 2015
  end-page: 1137
  ident: CR8
  article-title: Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice
  publication-title: Diabetologia
  doi: 10.1007/s00125-015-3523-x
– volume: 21
  start-page: 217
  year: 2021
  end-page: 238
  ident: CR1
  article-title: The matrix in cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-020-00329-7
– volume: 69
  start-page: 2241
  year: 2019
  end-page: 2257
  ident: CR18
  article-title: Mouse Models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis
  publication-title: Hepatology
  doi: 10.1002/hep.30333
– volume: 22
  start-page: 117
  year: 2023
  end-page: 127
  ident: CR17
  article-title: Matrix viscoelasticity controls spatiotemporal tissue organization
  publication-title: Nat. Mater.
  doi: 10.1038/s41563-022-01400-4
– volume: 114
  start-page: 450
  year: 2018
  end-page: 461
  ident: CR25
  article-title: Mechanisms of plastic deformation in collagen networks induced by cellular forces
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2017.11.3739
– volume: 9
  year: 2018
  ident: CR16
  article-title: Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06641-z
– volume: 506
  start-page: 289
  year: 2012
  end-page: 294
  ident: CR50
  article-title: Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern
  publication-title: Gene
  doi: 10.1016/j.gene.2012.07.009
– ident: CR21
– volume: 43
  start-page: 1785
  year: 2020
  end-page: 1796
  ident: CR28
  article-title: TEAD2 as a novel prognostic factor for hepatocellular carcinoma
  publication-title: Oncol. Rep.
– volume: 10
  year: 2019
  ident: CR47
  article-title: Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08465-x
– volume: 109
  start-page: 115
  year: 2017
  end-page: 126
  ident: CR29
  article-title: Tensins are versatile regulators of Rho GTPase signalling and cell adhesion
  publication-title: Biol. Cell
  doi: 10.1111/boc.201600053
– volume: 293
  start-page: 15620
  year: 2018
  end-page: 15627
  ident: CR24
  article-title: Glycation of type I collagen selectively targets the same helical domain lysine sites as lysyl oxidase-mediated cross-linking
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA118.004829
– volume: 1873
  start-page: 188356
  year: 2020
  ident: CR2
  article-title: Fibrosis and cancer: a strained relationship
  publication-title: Biochim. Biophys. Acta Rev. Cancer
  doi: 10.1016/j.bbcan.2020.188356
– volume: 60
  start-page: 2379
  year: 2011
  end-page: 2385
  ident: CR9
  article-title: Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial
  publication-title: Diabetes
  doi: 10.2337/db11-0291
– volume: 1043
  start-page: 696
  year: 2005
  end-page: 701
  ident: CR57
  article-title: Glycolaldehyde-modified bovine serum albumin downregulates leptin expression in mouse adipocytes via a CD36-mediated pathway
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1196/annals.1333.080
– volume: 1853
  start-page: 3258
  year: 2015
  end-page: 3265
  ident: CR34
  article-title: Tensin1 positively regulates RhoA activity through its interaction with DLC1
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2015.09.028
– volume: 7
  start-page: e35143
  year: 2012
  ident: CR49
  article-title: Effect of dietary advanced glycation end products on mouse liver
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0035143
– volume: 9
  year: 2018
  ident: CR14
  article-title: Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-02906-9
– volume: 59
  start-page: 95
  year: 2017
  end-page: 108
  ident: CR22
  article-title: Advanced glycation end-products: mechanics of aged collagen from molecule to tissue
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2016.09.001
– ident: CR43
– volume: 10
  start-page: 1841
  year: 2019
  end-page: 1855
  ident: CR11
  article-title: Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products
  publication-title: Biomed. Opt. Express
  doi: 10.1364/BOE.10.001841
– volume: 128
  start-page: 16
  year: 2018
  end-page: 25
  ident: CR41
  article-title: The fibrotic tumor stroma
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI93554
– volume: 67
  start-page: 331
  year: 2018
  end-page: 340
  ident: CR45
  article-title: Viscoelastic properties of human pancreatic tumors and in vitro constructs to mimic mechanical properties
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2017.11.037
– volume: 23
  start-page: 159
  year: 2005
  end-page: 165
  ident: CR46
  article-title: Viscoelastic shear properties of in vivo breast lesions measured by MR elastography
  publication-title: Magn. Reson. Imaging
  doi: 10.1016/j.mri.2004.11.060
– volume: 18
  year: 2020
  ident: CR36
  article-title: Breast cancer risk factors and their effects on survival: a Mendelian randomisation study
  publication-title: BMC Med.
  doi: 10.1186/s12916-020-01797-2
– volume: 75
  start-page: 1420
  year: 2022
  end-page: 1428
  ident: CR6
  article-title: Effect of diabetes medications and glycemic control on risk of hepatocellular cancer in patients with nonalcoholic fatty liver disease
  publication-title: Hepatology
  doi: 10.1002/hep.32244
– volume: 7
  start-page: 3480
  year: 2019
  end-page: 3488
  ident: CR23
  article-title: Glycated collagen—a 3D matrix system to study pathological cell behavior
  publication-title: Biomater. Sci.
  doi: 10.1039/C9BM00184K
– volume: 130
  start-page: 4320
  year: 2020
  end-page: 4330
  ident: CR10
  article-title: AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes
  publication-title: J. Clin. Invest.
– volume: 40
  start-page: S157
  year: 1997
  end-page: 159
  ident: CR53
  article-title: Pharmacological reversal of advanced glycation end-product-mediated protein crosslinking
  publication-title: Diabetologia
  doi: 10.1007/s001250051437
– volume: 15
  start-page: 326
  year: 2016
  end-page: 334
  ident: CR48
  article-title: Hydrogels with tunable stress relaxation regulate stem cell fate and activity
  publication-title: Nat. Mater.
  doi: 10.1038/nmat4489
– volume: 110
  start-page: 12197
  year: 2013
  end-page: 12202
  ident: CR26
  article-title: Strain history dependence of the nonlinear stress response of fibrin and collagen networks
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1222787110
– volume: 57
  start-page: 1465
  year: 2008
  end-page: 1472
  ident: CR51
  article-title: Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant -lipoic acid on insulin resistance in the obese Zucker rat
  publication-title: Metab. Clin. Exp.
  doi: 10.1016/j.metabol.2008.05.018
– volume: 52
  start-page: 389
  year: 2010
  end-page: 397
  ident: CR58
  article-title: Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2009.12.007
– volume: 5
  start-page: eaaw6171
  year: 2019
  ident: CR15
  article-title: Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27 signaling axis
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aaw6171
– volume: 19
  year: 2019
  ident: CR37
  article-title: Obesity, diabetes and the risk of colorectal adenoma and cancer
  publication-title: BMC Endocr. Disord.
  doi: 10.1186/s12902-019-0444-6
– ident: CR44
– volume: 149
  start-page: 468
  year: 2015
  end-page: 480
  ident: CR56
  article-title: Hepatocyte nicotinamide adenine dinucleotide phosphate reduced oxidase 4 regulates stress signaling, fibrosis, and insulin sensitivity during development of steatohepatitis in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.04.009
– volume: 124
  start-page: 263
  year: 2016
  end-page: 275
  ident: CR39
  article-title: Diabetes and cancer: a review of current knowledge
  publication-title: Exp. Clin. Endocrinol. Diabetes
  doi: 10.1055/s-0042-100910
– volume: 40
  start-page: 72
  year: 2020
  end-page: 76
  ident: CR5
  article-title: Natural history of NASH and HCC
  publication-title: Liver Int.
  doi: 10.1111/liv.14362
– volume: 11
  start-page: e0146588
  year: 2016
  ident: CR55
  article-title: Normal and fibrotic rat livers demonstrate shear strain softening and compression stiffening: a model for soft tissue mechanics
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0146588
– ident: CR13
– volume: 584
  start-page: 535
  year: 2020
  end-page: 546
  ident: CR12
  article-title: Effects of extracellular matrix viscoelasticity on cellular behaviour
  publication-title: Nature
  doi: 10.1038/s41586-020-2612-2
– volume: 82
  start-page: 1113
  year: 2014
  end-page: 1127
  ident: CR30
  article-title: Molecular physiology of the tensin brotherhood of integrin adaptor proteins
  publication-title: Proteins
  doi: 10.1002/prot.24560
– volume: 25
  start-page: 577
  year: 2007
  end-page: 583
  ident: CR52
  article-title: Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension
  publication-title: J. Hypertens.
  doi: 10.1097/HJH.0b013e328013e7dd
– volume: 66
  start-page: 1103
  year: 2017
  end-page: 1110
  ident: CR40
  article-title: Diabetes, pancreatogenic diabetes, and pancreatic cancer
  publication-title: Diabetes
  doi: 10.2337/db16-1477
– volume: 18
  start-page: 540
  year: 2016
  end-page: 548
  ident: CR32
  article-title: Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3336
– volume: 350
  start-page: g7607
  year: 2015
  ident: CR38
  article-title: Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies
  publication-title: Brit. Med. J.
  doi: 10.1136/bmj.g7607
– volume: 324
  start-page: 208
  year: 2009
  end-page: 212
  ident: CR33
  article-title: Multiscale modeling of form and function
  publication-title: Science
  doi: 10.1126/science.1170107
– volume: 73
  start-page: 4
  year: 2021
  end-page: 13
  ident: CR4
  article-title: Epidemiology of hepatocellular carcinoma
  publication-title: Hepatology
  doi: 10.1002/hep.31288
– volume: 139
  start-page: 891
  year: 2009
  end-page: 906
  ident: CR42
  article-title: Matrix crosslinking forces tumor progression by enhancing integrin signaling
  publication-title: Cell
  doi: 10.1016/j.cell.2009.10.027
– volume: 189
  start-page: 1077
  year: 2019
  end-page: 1090
  ident: CR54
  article-title: TEA domain transcription factor 4 Is the major mediator of yes-associated protein oncogenic activity in mouse and human hepatoblastoma
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2019.01.016
– volume: 24
  start-page: 1488
  year: 2017
  ident: 6991_CR35
  publication-title: Cell Death Differ.
  doi: 10.1038/cdd.2017.99
– volume: 1043
  start-page: 696
  year: 2005
  ident: 6991_CR57
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1196/annals.1333.080
– volume: 293
  start-page: 15620
  year: 2018
  ident: 6991_CR24
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.RA118.004829
– volume: 53
  start-page: 1192
  year: 2011
  ident: 6991_CR3
  publication-title: Hepatology
  doi: 10.1002/hep.24108
– volume: 40
  start-page: 72
  year: 2020
  ident: 6991_CR5
  publication-title: Liver Int.
  doi: 10.1111/liv.14362
– volume: 1873
  start-page: 188356
  year: 2020
  ident: 6991_CR2
  publication-title: Biochim. Biophys. Acta Rev. Cancer
  doi: 10.1016/j.bbcan.2020.188356
– volume: 43
  start-page: 1785
  year: 2020
  ident: 6991_CR28
  publication-title: Oncol. Rep.
– volume: 19
  year: 2019
  ident: 6991_CR37
  publication-title: BMC Endocr. Disord.
  doi: 10.1186/s12902-019-0444-6
– volume: 21
  start-page: 217
  year: 2021
  ident: 6991_CR1
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-020-00329-7
– volume: 73
  start-page: 4
  year: 2021
  ident: 6991_CR4
  publication-title: Hepatology
  doi: 10.1002/hep.31288
– volume: 60
  start-page: 2379
  year: 2011
  ident: 6991_CR9
  publication-title: Diabetes
  doi: 10.2337/db11-0291
– volume: 82
  start-page: 1113
  year: 2014
  ident: 6991_CR30
  publication-title: Proteins
  doi: 10.1002/prot.24560
– volume: 18
  start-page: 540
  year: 2016
  ident: 6991_CR32
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3336
– volume: 113
  start-page: 5492
  year: 2016
  ident: 6991_CR27
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1523906113
– volume: 59
  start-page: 95
  year: 2017
  ident: 6991_CR22
  publication-title: Matrix Biol.
  doi: 10.1016/j.matbio.2016.09.001
– volume: 506
  start-page: 289
  year: 2012
  ident: 6991_CR50
  publication-title: Gene
  doi: 10.1016/j.gene.2012.07.009
– volume: 58
  start-page: 1129
  year: 2015
  ident: 6991_CR8
  publication-title: Diabetologia
  doi: 10.1007/s00125-015-3523-x
– volume: 114
  start-page: 450
  year: 2018
  ident: 6991_CR25
  publication-title: Biophys. J.
  doi: 10.1016/j.bpj.2017.11.3739
– volume: 57
  start-page: 1465
  year: 2008
  ident: 6991_CR51
  publication-title: Metab. Clin. Exp.
  doi: 10.1016/j.metabol.2008.05.018
– volume: 69
  start-page: 2241
  year: 2019
  ident: 6991_CR18
  publication-title: Hepatology
  doi: 10.1002/hep.30333
– volume: 66
  start-page: 1103
  year: 2017
  ident: 6991_CR40
  publication-title: Diabetes
  doi: 10.2337/db16-1477
– volume: 11
  start-page: e0146588
  year: 2016
  ident: 6991_CR55
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0146588
– volume: 9
  year: 2018
  ident: 6991_CR16
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-06641-z
– volume: 75
  start-page: 1420
  year: 2022
  ident: 6991_CR6
  publication-title: Hepatology
  doi: 10.1002/hep.32244
– volume: 5
  start-page: eaaw6171
  year: 2019
  ident: 6991_CR15
  publication-title: Sci. Adv.
  doi: 10.1126/sciadv.aaw6171
– volume: 22
  start-page: 117
  year: 2023
  ident: 6991_CR17
  publication-title: Nat. Mater.
  doi: 10.1038/s41563-022-01400-4
– volume: 1853
  start-page: 3258
  year: 2015
  ident: 6991_CR34
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbamcr.2015.09.028
– volume: 110
  start-page: 12197
  year: 2013
  ident: 6991_CR26
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.1222787110
– volume: 284
  start-page: 34713
  year: 2009
  ident: 6991_CR31
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.059592
– ident: 6991_CR44
  doi: 10.1038/s41551-023-01019-z
– ident: 6991_CR13
  doi: 10.1038/s41563-021-00981-w
– volume: 25
  start-page: 577
  year: 2007
  ident: 6991_CR52
  publication-title: J. Hypertens.
  doi: 10.1097/HJH.0b013e328013e7dd
– volume: 324
  start-page: 208
  year: 2009
  ident: 6991_CR33
  publication-title: Science
  doi: 10.1126/science.1170107
– volume: 64
  start-page: 1587
  year: 2016
  ident: 6991_CR20
  publication-title: Hepatology
  doi: 10.1002/hep.28601
– volume: 23
  start-page: 159
  year: 2005
  ident: 6991_CR46
  publication-title: Magn. Reson. Imaging
  doi: 10.1016/j.mri.2004.11.060
– volume: 10
  start-page: 1841
  year: 2019
  ident: 6991_CR11
  publication-title: Biomed. Opt. Express
  doi: 10.1364/BOE.10.001841
– volume: 9
  year: 2018
  ident: 6991_CR14
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-02906-9
– volume: 29
  start-page: 18
  year: 2019
  ident: 6991_CR19
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2018.10.012
– volume: 286
  start-page: 44350
  year: 2011
  ident: 6991_CR7
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.282442
– ident: 6991_CR21
  doi: 10.3390/polym13162642
– volume: 124
  start-page: 263
  year: 2016
  ident: 6991_CR39
  publication-title: Exp. Clin. Endocrinol. Diabetes
  doi: 10.1055/s-0042-100910
– volume: 40
  start-page: S157
  year: 1997
  ident: 6991_CR53
  publication-title: Diabetologia
  doi: 10.1007/s001250051437
– volume: 584
  start-page: 535
  year: 2020
  ident: 6991_CR12
  publication-title: Nature
  doi: 10.1038/s41586-020-2612-2
– volume: 18
  year: 2020
  ident: 6991_CR36
  publication-title: BMC Med.
  doi: 10.1186/s12916-020-01797-2
– volume: 7
  start-page: e35143
  year: 2012
  ident: 6991_CR49
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0035143
– volume: 350
  start-page: g7607
  year: 2015
  ident: 6991_CR38
  publication-title: Brit. Med. J.
  doi: 10.1136/bmj.g7607
– volume: 7
  start-page: 3480
  year: 2019
  ident: 6991_CR23
  publication-title: Biomater. Sci.
  doi: 10.1039/C9BM00184K
– volume: 149
  start-page: 468
  year: 2015
  ident: 6991_CR56
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.04.009
– volume: 130
  start-page: 4320
  year: 2020
  ident: 6991_CR10
  publication-title: J. Clin. Invest.
– volume: 189
  start-page: 1077
  year: 2019
  ident: 6991_CR54
  publication-title: Am. J. Pathol.
  doi: 10.1016/j.ajpath.2019.01.016
– volume: 128
  start-page: 16
  year: 2018
  ident: 6991_CR41
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI93554
– volume: 10
  year: 2019
  ident: 6991_CR47
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-08465-x
– volume: 15
  start-page: 326
  year: 2016
  ident: 6991_CR48
  publication-title: Nat. Mater.
  doi: 10.1038/nmat4489
– ident: 6991_CR43
– volume: 67
  start-page: 331
  year: 2018
  ident: 6991_CR45
  publication-title: Acta Biomater.
  doi: 10.1016/j.actbio.2017.11.037
– volume: 109
  start-page: 115
  year: 2017
  ident: 6991_CR29
  publication-title: Biol. Cell
  doi: 10.1111/boc.201600053
– volume: 139
  start-page: 891
  year: 2009
  ident: 6991_CR42
  publication-title: Cell
  doi: 10.1016/j.cell.2009.10.027
– volume: 52
  start-page: 389
  year: 2010
  ident: 6991_CR58
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2009.12.007
SSID ssj0005174
Score 2.6620214
Snippet Type 2 diabetes mellitus is a major risk factor for hepatocellular carcinoma (HCC). Changes in extracellular matrix (ECM) mechanics contribute to cancer...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 635
SubjectTerms 13
13/51
13/95
14
38
631/57
631/67/1504/1610
692/699/1503/1607/2751
82
Advanced glycosylation end products
Age
Animal models
Animals
beta Catenin - metabolism
Carcinoma, Hepatocellular - complications
Carcinoma, Hepatocellular - metabolism
Carcinoma, Hepatocellular - pathology
Cell Proliferation
Collagen
Collagen - chemistry
Collagen - metabolism
Computer Simulation
Connectivity
Cross-linking
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diet
Disease Progression
Elasticity
Energy dissipation
Extracellular matrix
Extracellular Matrix - metabolism
Glycation End Products, Advanced - metabolism
Hepatocellular carcinoma
Heterogeneity
Humanities and Social Sciences
Humans
Hydrogels
Integrin beta1 - metabolism
Liver cancer
Liver Cirrhosis - complications
Liver Cirrhosis - metabolism
Liver Cirrhosis - pathology
Liver Neoplasms - complications
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Matrix methods
Mechanical properties
Microscopy
multidisciplinary
Neoplasm Invasiveness
Risk factors
Science
Science (multidisciplinary)
Signal transduction
Stiffness
Stress relaxation
Tensin
Viscoelasticity
Viscosity
YAP-Signaling Proteins - metabolism
Yes-associated protein
SummonAdditionalLinks – databaseName: Springer Nature OA Free Journals
  dbid: C6C
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bS9xAFD5YpdAXUXuL2jJCH1ra0Ewmc3uUpSKCvrSCb2FuwQXJymYt-u-dM0lW1kuhr5kzSSYnZ86XzDffAfjCg-I2psXcVDbklecyt6ypck-tM4Xy8Sj-0D89E8fn1ckFv1iDctwLk0j7SdIyTdMjO-xnFxONQros1iJAto5-BRso3Y4fXBMxeaB1PFJeHjbKFEw9c47VZPQEYT4lSj5aLU1J6GgLNgf0SA77-92GtdDuwOvE4nTdDmwPkdqRr4Oc9Le38PsUVfhvyd9p52YhgmXkUS_uyHUi4kXbK6RmEIfun5PE1-q1Osi0JREeEiSKuOl8fjmLPXvrd3B-9OvP5DgfSinkjld0kQsjqIk42hqhuXacOS19yYT3jXTBM6kLLCRpeFF6HWhhvLJFQ62wsvHSC_Ye1ttZGz4CcWVQujERdxSu0kEa3ojgFEpAUmuaKgM6PtPaDTrjWO7iqk7r3UzVvR_q6Ic6-aHWGXxf9rnuVTb-ab0_uqoeIq6rS43KcVRIlsHBsjnGCi6AmDbMbpJNnNp5xFgZfOg9u7wcwz3GtJQZqBWfLw1Qh3u1pZ1eJj1uLFYlZBFH_mN8PR7u6-Vh7P6f-R68KSOgQsY45fuwvpjfhE8REC3s5xQB94rRBIA
  priority: 102
  providerName: Springer Nature
Title Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver
URI https://link.springer.com/article/10.1038/s41586-023-06991-9
https://www.ncbi.nlm.nih.gov/pubmed/38297127
https://www.proquest.com/docview/2928351673
https://www.proquest.com/docview/2921115635
https://pubmed.ncbi.nlm.nih.gov/PMC10866704
Volume 626
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ba9RAFD7YFsEXsfUWrcsIPigamkkytyfRpWsRWkQt7FuYW-hCSdbNttR_75xJdpdtsS-BZM6QTM7MnI-Zb74D8I55yUwIi6kujU9Lx0RqirpMHTVWZ9KFp7igf3rGT87L71M2HRbcuoFWuZoT40TtWotr5Ee5QmUwykXxef4nxaxRuLs6pNDYgT0aIg1SuuTk24bicUuFeTg0kxXyqAuBSyL9FnMbIPtHbQemO2jzLmny1s5pDEiTJ_B4QJLkS-_6fXjgmwN4GBmdtjuA_WHUduT9IC394Sn8OkVF_htyPets6wNwRk718i-ZR1JesL1Emgax2BUWJHK3et0OMmtIgIoESSN2tlhctKFmb_0MzifHv8cn6ZBWIbWspMuUa051wNRGc8WUZYVVwuUFd64W1rtCqAyTSmqW5U55mmknTVZTw42onXC8eA67Tdv4l0Bs7qWqdcAgmS2VF5rV3FuJcpDU6LpMgK7-aWUHzXFMfXFZxb3vQla9H6rghyr6oVIJfFzXmfeKG_daH65cVQ2jr6s2fSWBt-viMG5wM0Q3vr2KNmGaZwFvJfCi9-z6dQWeN6a5SEBu-XxtgJrc2yXN7CJqc2PiKi6y0PJPq-6x-a7_N-PV_c14DY_yAKaQLU7ZIewuF1f-TQBDSzOCHTEV4SrHdBR7_wj2vh6f_fgZ7sZ8_A_T7ArR
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Nb9QwEB2VIgQXRMtXoICRQAJB1DiO7fiAEAKWLe32Qiv1ljq2o65UZZfNFuif4jficZJdbSt66zWZfDgz9rzYz28AXnGX89KnxVhnpYszy2VcsiqLLS2NTnLrj-KE_mhfDA-z70f8aA3-9nthkFbZj4lhoLYTg3Pk26lCZTAqJPs4_Rlj1ShcXe1LaLRhsevOf_tftubDzhfv39dpOvh68HkYd1UFYsMzOo-FFlR7SFlqobgynBklbcqEtZU0zjKpEqypqHmSWuVoom1eJhUtRSkrK61g_r434GbGfCbHnemDb0tKyQXV526TTsLy7cYnyhzpvlhLAdlGajURXkK3l0maF1ZqQwIc3IO7HXIln9pQ24A1V2_CrcAgNc0mbHSjREPedFLWb-_DjxFWAPhDfo0bM3EeqCOHe35OpoEE6G1PkRZCDIbejASuWKsTQsY18dCUIEnFjGezk4m_srV-AIfX8sEfwno9qd1jICZ1uaq0xzyJyZSTmlfCmRzlJ2mpqywC2n_TwnQa51hq47QIa-0sL1o_FN4PRfBDoSJ4t7hm2ip8XGm91buq6Hp7UyxjM4KXi9O-n-Lii67d5CzY-LTCPb6L4FHr2cXjGO5vpqmMIF_x-cIANcBXz9Tjk6AFjoWyhEx8y9_34bF8r_8348nVzXgBt4cHo71ib2d_9yncST2QQ6Y65VuwPp-duWceiM3L5yH6CRxfd3f7B92UQ-Y
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Nb9QwEB2VIhAXRMtXoICRQAJBtEkcx_YBIdSyaimtkKBSb8GxHXWlKlk2W6B_jV_HTD62bCt663UzSdaZGc9L_PwG4IXwShRYFkOTFj5MnZBhwcs0dHFhTaQc_kof9Pf2s-2D9NOhOFyBP8NeGKJVDnNiO1G72tI38lGiSRksziQflT0t4svW-P30R0gdpGildWin0YXIrj_9ha9vzbudLfT1yyQZf_y2uR32HQZCK9J4HmYmiw3Cy8JkWmgruNXSJTxzrpTWOy51RP0VjYgSp30cGaeKqIyLrJClky7jeN1rcF1yqSjH1OY_9JJzCtD9hp2Iq1GDRVMR9Zf6KhDzSC8XxQtI9yJh89yqbVsMx3fgdo9i2Ycu7NZgxVfrcKNlk9pmHdb6GaNhr3pZ69d34esedQP4zX5OGlt7BO3E556fsmlLCETbY6KIMEthOGMtb6zTDGGTiiFMZURYsZPZ7KjGMzvre3BwJQ_8PqxWdeUfArOJV7o0iH8im2ovjSgzbxVJUcaFKdMA4uGZ5rbXO6e2G8d5u-7OVd75IUc_5K0fch3Am8U5007t41LrjcFVeZ_5TX4WpwE8XxzGnKWFGFP5-qS1wRIjEOsF8KDz7OJ2nPY6x4kMQC35fGFAeuDLR6rJUasLTk2zMhnhyN8O4XH2v_4_jEeXD-MZ3MREyz_v7O8-hlsJYjoircdiA1bnsxP_BDHZvHjaBj-D71edbX8BmJ1H5w
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Matrix+viscoelasticity+promotes+liver+cancer+progression+in+the+pre-cirrhotic+liver&rft.jtitle=Nature+%28London%29&rft.au=Fan%2C+Weiguo&rft.au=Adebowale%2C+Kolade&rft.au=V%C3%A1ncza%2C+L%C3%B3r%C3%A1nd&rft.au=Li%2C+Yuan&rft.date=2024-02-15&rft.pub=Nature+Publishing+Group+UK&rft.issn=0028-0836&rft.eissn=1476-4687&rft.volume=626&rft.issue=7999&rft.spage=635&rft.epage=642&rft_id=info:doi/10.1038%2Fs41586-023-06991-9&rft_id=info%3Apmid%2F38297127&rft.externalDocID=PMC10866704
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon