Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease

• Published in: Cell metabolism Vol. 25; no. 3; pp. 713 - 726
• Main Authors: Falkevall, Annelie, Mehlem, Annika, Palombo, Isolde, Heller Sahlgren, Benjamin, Ebarasi, Lwaki, He, Liqun, Ytterberg, A. Jimmy, Olauson, Hannes, Axelsson, Jonas, Sundelin, Birgitta, Patrakka, Jaakko, Scotney, Pierre, Nash, Andrew, Eriksson, Ulf
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.03.2017
• Subjects: Adult; Aged; albuminuria; Albuminuria - complications; Albuminuria - metabolism; Albuminuria - pathology; Animals; Antibodies, Neutralizing - administration & dosage; Antibodies, Neutralizing - pharmacology; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - pathology; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; diabetic kidney disease; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic Nephropathies - prevention & control; Disease Models, Animal; Disease Progression; Dyslipidemias - complications; Dyslipidemias - metabolism; Dyslipidemias - pathology; endothelial fatty acid transport; Fatty Acid Transport Proteins - metabolism; Female; Gene Deletion; Humans; Insulin - pharmacology; insulin signaling; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidney - physiopathology; Lipids - toxicity; lipotoxicity; Male; Mice, Inbred C57BL; Middle Aged; podocytes; Podocytes - drug effects; Podocytes - metabolism; Podocytes - pathology; renal steatosis; Signal Transduction - drug effects; Up-Regulation - drug effects; vascular endothelial growth factor B; Vascular Endothelial Growth Factor B - metabolism; Young Adult; diabetic kidney disease; albuminuria; insulin signaling; podocytes; lipotoxicity; endothelial fatty acid transport; vascular endothelial growth factor B; renal steatosis

Diabetic kidney disease (DKD) is the most common cause of severe renal disease, and few treatment options are available today that prevent the progressive loss of renal function. DKD is characterized by altered glomerular filtration and proteinuria. A common observation in DKD is the presence of ren...