PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma

• Published in: Nature communications Vol. 15; no. 1; pp. 5300 - 17
• Main Authors: Huang, Sheng-Yan, Gong, Sha, Zhao, Yin, Ye, Ming-Liang, Li, Jun-Yan, He, Qing-Mei, Qiao, Han, Tan, Xi-Rong, Wang, Jing-Yun, Liang, Ye-Lin, Huang, Sai-Wei, He, Shi-Wei, Li, Ying-Qin, Xu, Sha, Li, Ying-Qing, Liu, Na
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 101/58; 13/1; 13/51; 13/89; 14/19; 14/63; 38/23; 38/61; 42/109; 5-Fluorouracil; 631/67/1059/2326; 631/67/1536; 64/60; 692/4028/67/395; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antitumor activity; Cancer; Cell Line, Tumor; Chemoresistance; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Cisplatin - therapeutic use; Docetaxel - pharmacology; Docetaxel - therapeutic use; Drug Resistance, Neoplasm - drug effects; Drug Resistance, Neoplasm - genetics; Dynamins - genetics; Dynamins - metabolism; Female; Fluorouracil - pharmacology; Fluorouracil - therapeutic use; Gasdermins; Gene Expression Regulation, Neoplastic - drug effects; Humanities and Social Sciences; Humans; Immune response; Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; multidisciplinary; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - drug therapy; Nasopharyngeal Carcinoma - genetics; Nasopharyngeal Carcinoma - metabolism; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Neoplasms - drug therapy; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; Patients; Phosphoprotein Phosphatases - genetics; Phosphoprotein Phosphatases - metabolism; Phosphorylation; Phosphorylation - drug effects; Proteasomes; Pyroptosis; Pyroptosis - drug effects; Pyroptosis - genetics; Reactive oxygen species; Reactive Oxygen Species - metabolism; Regulatory mechanisms (biology); Science; Science (multidisciplinary); Sensitivity enhancement; Throat cancer; Ubiquitin-protein ligase; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Ubiquitination - drug effects; Xenograft Model Antitumor Assays

Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal carcinoma, but the exact regulatory mechanism underlying chemoresistance in nasopharyngeal carcinoma remains to be elucidated. Here, we identify PJA1 as a key E3 ubiquitin ligase involved in nasopharyngeal carcino...