Morphologic and genomic changes of thyroid cancer cell lines exposed to conditions of simulated microgravity

• Published in: NPJ microgravity Vol. 10; no. 1; pp. 8 - 14
• Main Authors: Ahn, Jong-hyuk, Park, Sungyeon, Hwang, Young Mi, Choi, Yun Suk, Yi, Jin Wook
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/68; 692/699/67/1459/1843; Applied Microbiology; Biomedical and Life Sciences; Biotechnology; Cell culture; Classical and Continuum Physics; Down-regulation; Gene expression; Histones; Hypoxia; Immunology; Life Sciences; Microgravity; MicroRNAs; miRNA; Proteins; Space Exploration and Astronautics; Space Sciences (including Extraterrestrial Physics; Spheroids; Surgery; Thyroid cancer; Tumor cell lines; Weightlessness
• ISSN: 2373-8065; 2373-8065
• DOI: 10.1038/s41526-024-00346-y

Microgravity in space impacts human health. In particular, thyroid cancer, which has a high incidence rate, has been the subject of numerous studies with respect to microgravity. However, most studies have focused on Western follicular thyroid cancer cell lines, while data regarding the effects of m...