DNA methylation markers for kidney function and progression of diabetic kidney disease

• Published in: Nature communications Vol. 14; no. 1; pp. 2543 - 16
• Main Authors: Li, Kelly Yichen, Tam, Claudia Ha Ting, Liu, Hongbo, Day, Samantha, Lim, Cadmon King Poo, So, Wing Yee, Huang, Chuiguo, Jiang, Guozhi, Shi, Mai, Lee, Heung Man, Lan, Hui-yao, Szeto, Cheuk-Chun, Hanson, Robert L., Nelson, Robert G., Susztak, Katalin, Chan, Juliana C. N., Yip, Kevin Y., Ma, Ronald C. W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.05.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/61; 631/208/177; 692/163/2743/137/138; 692/308/575; 692/699/1585; Biomarkers; CpG islands; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic nephropathy; Disease Progression; DNA methylation; DNA Methylation - genetics; Epidermal growth factor receptors; Epigenetics; Genetic Markers; Glomerular filtration rate; Humanities and Social Sciences; Humans; Indigenous peoples; Kidney - metabolism; Kidney diseases; Kidneys; multidisciplinary; Native Americans; Prospective Studies; Renal Insufficiency, Chronic - genetics; Science; Science (multidisciplinary)

Epigenetic markers are potential biomarkers for diabetes and related complications. Using a prospective cohort from the Hong Kong Diabetes Register, we perform two independent epigenome-wide association studies to identify methylation markers associated with baseline estimated glomerular filtration...