Identification of novel interacts partners of ADAR1 enzyme mediating the oncogenic process in aggressive breast cancer

• Published in: Scientific reports Vol. 13; no. 1; pp. 8341 - 11
• Main Authors: Binothman, Najat, Aljadani, Majidah, Alghanem, Bandar, Refai, Mohammed Y., Rashid, Mamoon, Al Tuwaijri, Abeer, Alsubhi, Nouf H., Alrefaei, Ghadeer I., Khan, Muhammad Yasir, Sonbul, Sultan N., Aljoud, Fadwa, Alhayyani, Sultan, Abdulal, Rwaa H., Ganash, Magdah, Hashem, Anwar M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.05.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/67; Adenosine Deaminase - metabolism; Aggressive behavior; Breast; Breast cancer; Carcinoma; Clinical outcomes; Complement C4; Complement component C4; Gene expression; Histone H2A; Histones; Humanities and Social Sciences; Humans; Immunoprecipitation; Mass spectrometry; Mass spectroscopy; multidisciplinary; Proteins; RNA-Binding Proteins - metabolism; Science; Science (multidisciplinary); Triple Negative Breast Neoplasms - pathology; Tumors

Triple-negative breast cancer (TNBC) subtype is characterized by aggressive clinical behavior and poor prognosis patient outcomes. Here, we show that ADAR1 is more abundantly expressed in infiltrating breast cancer (BC) tumors than in benign tumors. Further, ADAR1 protein expression is higher in agg...