Transcriptome variation in human populations and its potential application in forensics

• Published in: Journal of applied genetics Vol. 60; no. 3-4; pp. 319 - 328
• Main Authors: Daca-Roszak, P., Zietkiewicz, E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2019; Springer; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Biomedical and Life Sciences; Biotechnology industry; Cell Separation - methods; DNA Fingerprinting; Forensic science; Forensic sciences; Forensic Sciences - trends; Gene expression; Genetic Variation - genetics; Human Genetics; Human Genetics • Review; Human populations; Humans; Life Sciences; Markers; Microbial Genetics and Genomics; Plant Genetics and Genomics; Population; State-of-the-art reviews; Transcriptome - genetics; United States; Laser capture microdissection; Transcriptome variation; Human population identification; Forensic identification
• ISSN: 1234-1983; 2190-3883
• DOI: 10.1007/s13353-019-00510-1

This review presents the state-of-the-art in the forensic application of genetic methods driven by the research in population transcriptomics. In the first part of the review, the constraints of using classical genomic markers are shortly reviewed. In the second part, the developments in the field of inter-population diversity at the transcriptomic level are presented. Subsequently, a potential of population-specific transcriptomic markers in forensic science applications, including ascertaining population affiliation of human samples and cell mixtures separation, are presented.