PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells - Agrawal Singh, Shuchi; Lerdrup, Mads; Gomes, Ana-Luisa R; van de Werken, Harmen JG; Vilstrup Johansen, Jens; Andersson, Robin; Sandelin, Albin; Helin, Kristian; Hansen, Klaus (eLife, 2019)
Keywords: Acetylation; Biology; Cancer; Cell Differentiation - genetics; Cell Lineage - genetics; Chromatin - metabolism; Chromosomes and Gene Expression; developmental enhancer; Embryonic Development - genetics; Enhancer Elements, Genetic - genetics; Enhancers; Epigenesis, Genetic; Epigenetics; Event-related potentials; Gene expression; Gene loci; Genetic Loci; Genomes; histone H3 lysine 27 tri-methylation; Histones - metabolism; human mesenchymal stem cells; Humans; Hypothesis testing; Lysine - metabolism; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Mesenchyme; Methyltransferase; Mineralization; N-Methyltransferase; Nicotinamide; Nicotinamide N-methyltransferase; Nicotinamide N-Methyltransferase - genetics; Nicotinamide N-Methyltransferase - metabolism; Osteoblastogenesis; osteogenesis; Osteogenesis - genetics; PLZF; Polycomb group proteins; Polycomb proteins; Promoter Regions, Genetic; Promyelocytic Leukemia Zinc Finger Protein - genetics; Promyelocytic Leukemia Zinc Finger Protein - metabolism; Protein Binding; Proteins; RNA - genetics; Stem cells; Transcription factors; Transcriptome - genetics; Denmark; New York; Netherlands; United States--US; Copenhagen Denmark; developmental enhancer; histone H3 lysine 27 tri-methylation; human mesenchymal stem cells; ZBTB16; chromosomes; osteogenesis; PLZF; human; Polycomb proteins; gene expression