Associations between prefrontal γ-aminobutyric acid concentration and the tryptophan hydroxylase isoform 2 gene, a panic disorder risk allele in women

• Published in: The international journal of neuropsychopharmacology Vol. 16; no. 8; pp. 1707 - 1717
• Main Authors: Preuss, Nora, Salehi, Basira, van der Veen, Jan Willem, Shen, Jun, Drevets, Wayne C., Hodgkinson, Colin, Goldman, David, Hasler, Gregor
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.09.2013; Oxford University Press
• Subjects: Adult; Alleles; Anxiety; Depressive Disorder, Major - genetics; Depressive Disorder, Major - pathology; Female; gamma-Aminobutyric Acid - metabolism; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Linkage Disequilibrium; Magnetic Resonance Spectroscopy; Male; Middle Aged; Panic attacks; Panic Disorder - genetics; Panic Disorder - pathology; Polymorphism, Single Nucleotide - genetics; Prefrontal Cortex - metabolism; Psychiatric Status Rating Scales; RNA, Messenger - metabolism; Sex Characteristics; Tryptophan Hydroxylase - genetics; Young Adult; GABA; magnetic resonance spectroscopy; genetics; tryptophan hydroxylase 2; single nucleotide polymorphisms

Associations between the central serotonergic and γ-aminobutyric acid (GABA) systems play key roles in the prefrontal cortical regulation of emotion and cognition and in the pathophysiology and pharmacotherapy of highly prevalent psychiatric disorders. The goal of this study was to test the effects...