Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model
Five novel, canine lymphoma cell lines (Ema, CLC, CLK, Nody-1 and UL-1) were established from dogs suffering from lymphoma and characterized in vitro and in vivo. All cell lines, except CLC, were characterized with T-cell phenotypes, by flow cytometric analysis and polymerase chain reaction for anti...
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| Published in | Journal of Veterinary Medical Science Vol. 75; no. 4; pp. 467 - 474 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Japan
JAPANESE SOCIETY OF VETERINARY SCIENCE
2013
Japan Science and Technology Agency |
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| Online Access | Get full text |
| ISSN | 0916-7250 1347-7439 1347-7439 |
| DOI | 10.1292/jvms.12-0448 |
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| Abstract | Five novel, canine lymphoma cell lines (Ema, CLC, CLK, Nody-1 and UL-1) were established from dogs suffering from lymphoma and characterized in vitro and in vivo. All cell lines, except CLC, were characterized with T-cell phenotypes, by flow cytometric analysis and polymerase chain reaction for antigen receptor rearrangement. Cell proliferation rates and transcriptional levels of MYC, PTEN, KIT and FLT3 varied between each cell line. Intraperitoneal xenotransplantation of Ema, CLC, Nody-1 and UL-1 lymphoma cell lines into NOD/SCID mice induced ascites, intraperitoneal tumors and severe infiltration of lymphoma cells into the pancreas and mesentery. Establishment of novel canine lymphoma cell lines with different characteristics is critical for elucidating the pathophysiology of canine lymphoma and improving current therapies. |
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| AbstractList | Five novel, canine lymphoma cell lines (Ema, CLC, CLK, Nody-1 and UL-1) were established from dogs suffering from lymphoma and characterized in vitro and in vivo. All cell lines, except CLC, were characterized with T-cell phenotypes, by flow cytometric analysis and polymerase chain reaction for antigen receptor rearrangement. Cell proliferation rates and transcriptional levels of MYC, PTEN, KIT and FLT3 varied between each cell line. Intraperitoneal xenotransplantation of Ema, CLC, Nody-1 and UL-1 lymphoma cell lines into NOD/SCID mice induced ascites, intraperitoneal tumors and severe infiltration of lymphoma cells into the pancreas and mesentery. Establishment of novel canine lymphoma cell lines with different characteristics is critical for elucidating the pathophysiology of canine lymphoma and improving current therapies. Five novel, canine lymphoma cell lines (Ema, CLC, CLK, Nody-1 and UL-1) were established from dogs suffering from lymphoma and characterized in vitro and in vivo. All cell lines, except CLC, were characterized with T-cell phenotypes, by flow cytometric analysis and polymerase chain reaction for antigen receptor rearrangement. Cell proliferation rates and transcriptional levels of MYC, PTEN, KIT and FLT3 varied between each cell line. Intraperitoneal xenotransplantation of Ema, CLC, Nody-1 and UL-1 lymphoma cell lines into NOD/SCID mice induced ascites, intraperitoneal tumors and severe infiltration of lymphoma cells into the pancreas and mesentery. Establishment of novel canine lymphoma cell lines with different characteristics is critical for elucidating the pathophysiology of canine lymphoma and improving current therapies.Five novel, canine lymphoma cell lines (Ema, CLC, CLK, Nody-1 and UL-1) were established from dogs suffering from lymphoma and characterized in vitro and in vivo. All cell lines, except CLC, were characterized with T-cell phenotypes, by flow cytometric analysis and polymerase chain reaction for antigen receptor rearrangement. Cell proliferation rates and transcriptional levels of MYC, PTEN, KIT and FLT3 varied between each cell line. Intraperitoneal xenotransplantation of Ema, CLC, Nody-1 and UL-1 lymphoma cell lines into NOD/SCID mice induced ascites, intraperitoneal tumors and severe infiltration of lymphoma cells into the pancreas and mesentery. Establishment of novel canine lymphoma cell lines with different characteristics is critical for elucidating the pathophysiology of canine lymphoma and improving current therapies. |
| Author | SUZUKI, Ryoichi OKAMURA, Yasuhiko TSUJIMOTO, Hajime EMA, Yasuo OKUDA, Masaru UMEKI, Saori TANI, Kenji MIZUNO, Takuya KUBO, Masahito HAYASHI, Toshiharu YAMAZAKI, Jumpei HIRAOKA, Hiroko |
| Author_xml | – sequence: 1 fullname: YAMAZAKI, Jumpei organization: Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania, U.S.A – sequence: 1 fullname: OKUDA, Masaru organization: Biomedical Science Center for Translational Research, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: KUBO, Masahito organization: Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: HAYASHI, Toshiharu organization: Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: TSUJIMOTO, Hajime organization: Laboratory of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan – sequence: 1 fullname: SUZUKI, Ryoichi organization: Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: EMA, Yasuo organization: Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: OKAMURA, Yasuhiko organization: Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3–18–8 Ueda, Morioka, Iwate 020–8550, Japan – sequence: 1 fullname: TANI, Kenji organization: Laboratory of Veterinary Surgery, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: HIRAOKA, Hiroko organization: Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: UMEKI, Saori organization: Laboratory of Veterinary Internal Medicine, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan – sequence: 1 fullname: MIZUNO, Takuya organization: Biomedical Science Center for Translational Research, The United Graduate School of Veterinary Science, Yamaguchi University, 1677–1 Yoshida, Yamaguchi 753–8515, Japan |
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| Cites_doi | 10.1292/jvms.71.555 10.1016/j.leukres.2007.04.003 10.1111/j.1939-1676.2011.0756.x 10.1016/j.leukres.2011.11.004 10.1186/1471-2407-11-38 10.1002/hon.2017 10.1016/S0165-2427(97)00053-6 10.1292/jvms.58.469 10.1354/vp.40-1-32 10.1111/j.1476-5829.2007.00139.x 10.1111/j.1476-5829.2011.00299.x |
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| References | 8. Nakaichi, M., Taura, Y., Kanki, M., Mamba, K., Momoi, Y., Tsujimoto, H. and Nakama, S. 1996. Establishment and characterization of a new canine B-cell leukemia cell line. J. Vet. Med. Sci. 58: 469–471. 5. Marconato, L., Gelain, M. E. and Comazzi, S. 2012. The dog as a possible animal model for human non-Hodgkin lymphoma: a review. Hematol. Oncol. (in press). 9. Seiser, E. L., Thomas, R., Richards, K. L., Kathryn Kelley, M., Moore, P., Suter, S. E. and Breen, M. 2011. Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines. Vet. Comp. Oncol. (in press). 4. Kisseberth, W. C., Nadella, M. V., Breen, M., Thomas, R., Duke, S. E., Murahari, S., Kosarek, C. E., Vernau, W., Avery, A. C., Burkhard, M. J. and Rosol, T. J. 2007. A novel canine lymphoma cell line: a translational and comparative model for lymphoma research. Leuk. Res. 31: 1709–1720. 7. Nadella, M. V., Kisseberth, W. C., Nadella, K. S., Thudi, N. K., Thamm, D. H., McNiel, E. A., Yilmaz, A., Boris-Lawrie, K. and Rosol, T. J. 2008. NOD/SCID mouse model of canine T-cell lymphoma with humoral hypercalcaemia of malignancy: cytokine gene expression profiling and in vivo bioluminescent imaging. Vet. Comp. Oncol. 6: 39–54. 11. Zwingenberger, A. L., Vernau, W., Shi, C., Yan, W., Chen, X., Gordon, I. K. and Kent, M. S. 2012. Development and characterization of 5 canine B-cell lymphoma cell lines. Leuk. Res. 36: 601–606. 6. Momoi, Y., Okai, Y., Watari, T., Goitsuka, R., Tsujimoto, H. and Hasegawa, A. 1997. Establishment and characterization of a canine T-lymphoblastoid cell line derived from malignant lymphoma. Vet. Immunol. Immunopathol. 59: 11–20. 3. Kaneko, N., Yamamoto, Y., Wada, Y., Shimokawa Miyama, T., Hiraoka, H., Itamoto, K., Mizuno, T., Nakaichi, M., Takahashi, T., Watari, T. and Okuda, M. 2009. Application of polymerase chain reaction to analysis of antigen receptor rearrangements to support endoscopic diagnosis of canine alimentary lymphoma. J. Vet. Med. Sci. 71: 555–559. 10. Suter, S. E., Small, G. W., Seiser, E. L., Thomas, R., Breen, M. and Richards, K. L. 2011. FLT3 mutations in canine acute lymphocytic leukemia. BMC Cancer 11: 38. 1. Burnett, R. C., Vernau, W., Modiano, J. F., Olver, C. S., Moore, P. F. and Avery, A. C. 2003. Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes. Vet. Pathol. 40: 32–41. 2. Ito, D., Endicott, M. M., Jubala, C. M., Helm, K. M., Burnett, R. C., Husbands, B. D., Borgatti, A., Henson, M. S., Burgess, K. E., Bell, J. S., Kisseberth, W. C., Valli, V. E., Cutter, G. R., Avery, A. C., Hahn, K. A., O’Brien, T. D. and Modiano, J. F. 2011. A tumor-related lymphoid progenitor population supports hierarchical tumor organization in canine B-cell lymphoma. J. Vet. Intern. Med. 25: 890–896. 11 1 2 3 4 5 6 7 8 9 10 |
| References_xml | – reference: 1. Burnett, R. C., Vernau, W., Modiano, J. F., Olver, C. S., Moore, P. F. and Avery, A. C. 2003. Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes. Vet. Pathol. 40: 32–41. – reference: 2. Ito, D., Endicott, M. M., Jubala, C. M., Helm, K. M., Burnett, R. C., Husbands, B. D., Borgatti, A., Henson, M. S., Burgess, K. E., Bell, J. S., Kisseberth, W. C., Valli, V. E., Cutter, G. R., Avery, A. C., Hahn, K. A., O’Brien, T. D. and Modiano, J. F. 2011. A tumor-related lymphoid progenitor population supports hierarchical tumor organization in canine B-cell lymphoma. J. Vet. Intern. Med. 25: 890–896. – reference: 10. Suter, S. E., Small, G. W., Seiser, E. L., Thomas, R., Breen, M. and Richards, K. L. 2011. FLT3 mutations in canine acute lymphocytic leukemia. BMC Cancer 11: 38. – reference: 9. Seiser, E. L., Thomas, R., Richards, K. L., Kathryn Kelley, M., Moore, P., Suter, S. E. and Breen, M. 2011. Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines. Vet. Comp. Oncol. (in press). – reference: 8. Nakaichi, M., Taura, Y., Kanki, M., Mamba, K., Momoi, Y., Tsujimoto, H. and Nakama, S. 1996. Establishment and characterization of a new canine B-cell leukemia cell line. J. Vet. Med. Sci. 58: 469–471. – reference: 4. Kisseberth, W. C., Nadella, M. V., Breen, M., Thomas, R., Duke, S. E., Murahari, S., Kosarek, C. E., Vernau, W., Avery, A. C., Burkhard, M. J. and Rosol, T. J. 2007. A novel canine lymphoma cell line: a translational and comparative model for lymphoma research. Leuk. Res. 31: 1709–1720. – reference: 7. Nadella, M. V., Kisseberth, W. C., Nadella, K. S., Thudi, N. K., Thamm, D. H., McNiel, E. A., Yilmaz, A., Boris-Lawrie, K. and Rosol, T. J. 2008. NOD/SCID mouse model of canine T-cell lymphoma with humoral hypercalcaemia of malignancy: cytokine gene expression profiling and in vivo bioluminescent imaging. Vet. Comp. Oncol. 6: 39–54. – reference: 3. Kaneko, N., Yamamoto, Y., Wada, Y., Shimokawa Miyama, T., Hiraoka, H., Itamoto, K., Mizuno, T., Nakaichi, M., Takahashi, T., Watari, T. and Okuda, M. 2009. Application of polymerase chain reaction to analysis of antigen receptor rearrangements to support endoscopic diagnosis of canine alimentary lymphoma. J. Vet. Med. Sci. 71: 555–559. – reference: 6. Momoi, Y., Okai, Y., Watari, T., Goitsuka, R., Tsujimoto, H. and Hasegawa, A. 1997. Establishment and characterization of a canine T-lymphoblastoid cell line derived from malignant lymphoma. Vet. Immunol. Immunopathol. 59: 11–20. – reference: 5. Marconato, L., Gelain, M. E. and Comazzi, S. 2012. The dog as a possible animal model for human non-Hodgkin lymphoma: a review. Hematol. Oncol. (in press). – reference: 11. Zwingenberger, A. L., Vernau, W., Shi, C., Yan, W., Chen, X., Gordon, I. K. and Kent, M. S. 2012. Development and characterization of 5 canine B-cell lymphoma cell lines. Leuk. Res. 36: 601–606. – ident: 3 doi: 10.1292/jvms.71.555 – ident: 4 doi: 10.1016/j.leukres.2007.04.003 – ident: 2 doi: 10.1111/j.1939-1676.2011.0756.x – ident: 11 doi: 10.1016/j.leukres.2011.11.004 – ident: 10 doi: 10.1186/1471-2407-11-38 – ident: 5 doi: 10.1002/hon.2017 – ident: 6 doi: 10.1016/S0165-2427(97)00053-6 – ident: 8 doi: 10.1292/jvms.58.469 – ident: 1 doi: 10.1354/vp.40-1-32 – ident: 7 doi: 10.1111/j.1476-5829.2007.00139.x – ident: 9 doi: 10.1111/j.1476-5829.2011.00299.x |
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| SubjectTerms | Animals canine lymphoma cell line Cell Line, Tumor Cell Proliferation characterization Dog Diseases - genetics Dog Diseases - pathology Dogs Female Immunophenotyping - veterinary Lymphoma - genetics Lymphoma - pathology Lymphoma - veterinary Male Mice Mice, Inbred NOD Mice, SCID Real-Time Polymerase Chain Reaction - veterinary Receptors, Antigen, T-Cell - genetics RNA, Neoplasm - chemistry RNA, Neoplasm - genetics Specific Pathogen-Free Organisms Transplantation, Heterologous - veterinary xenograft model |
| Title | Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model |
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