Ligand-enabled ruthenium-catalyzed meta-C−H alkylation of (hetero)aromatic carboxylic acids

• Published in: Nature communications Vol. 15; no. 1; pp. 5552 - 10
• Main Authors: Luo, Xianglin, Hou, Peichao, Shen, Jiayi, Kuang, Yifeng, Sun, Fengchao, Jiang, Huanfeng, Gooßen, Lukas J., Huang, Liangbin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403; 639/638/549; Acids; Alkylation; Amides; Aromatic compounds; Availability; Benzoates; Benzoic acid; Carboxylates; Carboxylic acids; Catalysis; Electron density; Esters; Functional groups; Halides; Humanities and Social Sciences; Ketones; Ligands; multidisciplinary; Nitriles; Ruthenium; Science; Science (multidisciplinary); Single electrons

Carboxylates are ideal directing groups because they are widely available, readily cleavable and excellent linchpins for diverse follow-up reactions. However, their use in meta -selective C−H functionalizations remains a substantial unmet catalytic challenge. Herein, we report the ruthenium-catalyze...