Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

• Published in: Acta neuropathologica Vol. 141; no. 1; pp. 85 - 100
• Main Authors: Suwala, Abigail K., Stichel, Damian, Schrimpf, Daniel, Kloor, Matthias, Wefers, Annika K., Reinhardt, Annekathrin, Maas, Sybren L. N., Kratz, Christian P., Schweizer, Leonille, Hasselblatt, Martin, Snuderl, Matija, Abedalthagafi, Malak Sameer J., Abdullaev, Zied, Monoranu, Camelia M., Bergmann, Markus, Pekrun, Arnulf, Freyschlag, Christian, Aronica, Eleonora, Kramm, Christof M., Hinz, Felix, Sievers, Philipp, Korshunov, Andrey, Kool, Marcel, Pfister, Stefan M., Sturm, Dominik, Jones, David T. W., Wick, Wolfgang, Unterberg, Andreas, Hartmann, Christian, Dodgshun, Andrew, Tabori, Uri, Wesseling, Pieter, Sahm, Felix, von Deimling, Andreas, Reuss, David E.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021; Springer; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; Analysis; Astrocytoma; Brain cancer; Cancer; Chemotherapy; Colon cancer; Copy number; Deoxyribonucleic acid; DNA; DNA methylation; DNA repair; DNA sequencing; Epigenetic inheritance; Epigenetics; Ethylenediaminetetraacetic acid; Gene mutations; Genotypes; Glioma; Gliomas; Immunohistochemistry; Medical colleges; Medical prognosis; Medicine; Medicine & Public Health; Methylation; Microsatellite instability; Mismatch repair; MLH1 protein; MSH2 protein; MSH6 protein; Mutants; Neurosciences; Original Paper; p53 Protein; Pathology; Prognosis; Tumor proteins; Tumors; Yeast; Young adults; CMMRD; Lynch; Prognosis; Mismatch repair; Glioblastoma; ATRX; DNA methylation; IDH; Subtype

Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. Acquired mismatch repair deficiency is known to occur in recurrent IDH-mutant gliomas as resistance mechanism towards alkylating chemotherapy. In this multi-institutio...