Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia

• Published in: Nature communications Vol. 15; no. 1; p. 2497
• Main Authors: Funes, Salome, Jung, Jonathan, Gadd, Del Hayden, Mosqueda, Michelle, Zhong, Jianjun, Shankaracharya, Unger, Matthew, Stallworth, Karly, Cameron, Debra, Rotunno, Melissa S., Dawes, Pepper, Fowler-Magaw, Megan, Keagle, Pamela J., McDonough, Justin A., Boopathy, Sivakumar, Sena-Esteves, Miguel, Nickerson, Jeffrey A., Lutz, Cathleen, Skarnes, William C., Lim, Elaine T., Schafer, Dorothy P., Massi, Francesca, Landers, John E., Bosco, Daryl A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 101/6; 13/100; 13/106; 14/19; 14/56; 14/63; 38/91; 631/378/1689/1285; 631/378/2596/1953; 64/110; 82/58; 82/83; Actin; Amyotrophic lateral sclerosis; Autophagy; Degradation; Humanities and Social Sciences; Lipid metabolism; Lipids; Microglia; multidisciplinary; Mutants; Mutation; Neurodegenerative diseases; Pathogenesis; Phagocytes; Phagocytosis; Pluripotency; Profilin; Rapamycin; Science; Science (multidisciplinary); Stem cells; Toxicity

Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like c...