Expression of ALS-PFN1 impairs vesicular degradation in iPSC-derived microglia
Microglia play a pivotal role in neurodegenerative disease pathogenesis, but the mechanisms underlying microglia dysfunction and toxicity remain to be elucidated. To investigate the effect of neurodegenerative disease-linked genes on the intrinsic properties of microglia, we studied microglia-like c...
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Published in | Nature communications Vol. 15; no. 1; p. 2497 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
20.03.2024
Nature Publishing Group Nature Portfolio |
Subjects | |
Online Access | Get full text |
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