Arginine methylation of HSPA8 by PRMT9 inhibits ferroptosis to accelerate hepatitis B virus-associated hepatocellular carcinoma progression

• Published in: Journal of translational medicine Vol. 21; no. 1; pp. 1 - 19
• Main Authors: Deng, Wensheng, Ai, Jiaoyu, Zhang, Wanlin, Zhou, Zhenyu, Li, Muqi, Yan, Likun, Zhang, Lidong, Huang, Zongjing, Wu, Ziyi, Ai, Junhua, Jiang, Hai
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 15.09.2023; BioMed Central; BMC
• Subjects: Antibodies; Arginine; Arginine methylation; Biotechnology; Care and treatment; CD44 antigen; Cloning; Control; Development and progression; DNA methylation; Dosage and administration; Ferroptosis; Health aspects; Hepatitis B; Hepatitis B virus; Hepatitis B virus X; Hepatocellular carcinoma; Hepatoma; HSPA8; Identification and classification; Infections; Lipid peroxidation; Liver cancer; Medical research; Methylation; PRMT9; Protein arginine methyltransferase; Proteins; Reagents; Research ethics; Transcriptomes; Transferases; Viruses; China; United States > US

Background The hepatitis B virus X (HBx) protein is an established cause of hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC). Whether arginine methylation regulates ferroptosis involved in HBx-induced HCC progression has not been reported. This study aimed to explore whether HBx-regula...