Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse β Cells

We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mou...

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Published inExperimental Animals Vol. 59; no. 4; pp. 515 - 519
Main Authors TERADA, Misao, SAITO, Toru R., KROMKHUN, Pudcharaporn, FUNGFUAUG, Wirasak, HASHIMOTO, Haruo, YOKOSUKA, Makoto, MORITANI, Naoki, NAKADA, Tomoaki
Format Journal Article
LanguageEnglish
Published Japan Japanese Association for Laboratory Animal Science 2010
Subjects
Animals
bioartificial endocrine pancreas
Diabetes Mellitus, Experimental - physiopathology
Diabetes Mellitus, Experimental - surgery
diabetic rats
Female
Hyperglycemia - surgery
Insulin-Secreting Cells
Islets of Langerhans Transplantation - methods
Mice
Ovariectomy
Pancreas, Artificial
Posture
Rats
Sexual Behavior, Animal - physiology
Sexual Dysfunction, Physiological - physiopathology
Sexual Dysfunction, Physiological - surgery
streptozotocin
Transplantation, Heterologous
Online AccessGet full text
ISSN1341-1357
1881-7122
DOI10.1538/expanim.59.515

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Abstract We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse β cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380–450 mg/dl induced by streptozotocin to 140–230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.
AbstractList We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse beta cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse beta cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380-450 mg/dl induced by streptozotocin to 140-230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.
We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse β cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380–450 mg/dl induced by streptozotocin to 140–230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.
Author FUNGFUAUG, Wirasak
KROMKHUN, Pudcharaporn
MORITANI, Naoki
YOKOSUKA, Makoto
NAKADA, Tomoaki
SAITO, Toru R.
TERADA, Misao
HASHIMOTO, Haruo
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  fullname: KROMKHUN, Pudcharaporn
  organization: Nippon Veterinary and Life Science University
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  fullname: FUNGFUAUG, Wirasak
  organization: Nippon Veterinary and Life Science University
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  fullname: HASHIMOTO, Haruo
  organization: Nippon Veterinary and Life Science University
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  fullname: YOKOSUKA, Makoto
  organization: Nippon Veterinary and Life Science University
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  fullname: MORITANI, Naoki
  organization: Nippon Veterinary and Life Science University
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– reference: 7. Hirotani, S., Eda, R., Kawabata, T., Fuchinoue, S., Teraoka, S., Agishi, T., and Ohgawara, H. 1999. Cell Transplant. 8: 399–404.
– reference: 3. Edamura, K., Nasu, K., Iwami, Y., Nishimura, R., Ogawa, H., Sasaki, N., Ohgawara, H. 2004. J. Vet. Med. Sci. 66: 129–135.
– reference: 10. Imagawa, A., Hanafusa, T., Miyagawa, J., and Matsuzawa, Y. 2000. Ann. Med. 32: 539–543.
– reference: 5. Hashimoto, H., Arai, T., Ohnishi, Y., Eto, T., Ito, M., Hioki, K., Suzuki, R., Yamauchi, T., Ohsugi, M., Saito, M., Ueyama, Y., Tobe, K., Kadowaki, T., Tamaoki, N., and Kosaka, K. 2007. Exp. Anim. 56: 149–154.
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– reference: 22. Steger, R.W. and Kienast, S.G. 1990. Diabetes 39: 942–948.
– reference: 23. Yonezawa, A., Ebiko, M., Yoshizumi, M., Ise, S.N., Watanabe, C., Mizoguchi, H., Iwasaki, M., Kimura, Y., and Sakurada, S. 2009. Int. J. Urol. 16: 208–211.
– reference: 6. Hashimoto, H., Arai, T., Takeguchi, A., Hioki, K., Ohnishi, Y., Kawai, K., Ito, M., Suzuki, R., Yamauchi, T., Ohsugi, M., Saito, M., Ueyama, Y., Tobe, K., Kadowaki, T., Tamaoki, N., and Kosaka, K. 2006. Comp. Med. 56: 176–187.
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– reference: 4. Hashimoto, H., Arai, T., Mori, A., Kawai, K., Hikishima, K., Ohnishi, Y., Eto, T., Ito, M., Hioki, K., Suzuki, R., Ohsugi, M., Saito, M., Ueyama, Y., Okano, H., Yamauchi, T., Kubota, N., Ueki, K., Tobe, K., Tamaoki, N., Kadowaki, T., and Kosaka, K. 2009. Exp. Clin. Endocrinol. Diabetes 117: 577–586.
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Snippet We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced...
We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse beta cells on sexual dysfunction of streptozotocin (STZ)-induced...
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SubjectTerms Animals
bioartificial endocrine pancreas
Diabetes Mellitus, Experimental - physiopathology
Diabetes Mellitus, Experimental - surgery
diabetic rats
Female
Hyperglycemia - surgery
Insulin-Secreting Cells
Islets of Langerhans Transplantation - methods
Mice
Ovariectomy
Pancreas, Artificial
Posture
Rats
Sexual Behavior, Animal - physiology
Sexual Dysfunction, Physiological - physiopathology
Sexual Dysfunction, Physiological - surgery
streptozotocin
Transplantation, Heterologous
Title Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse β Cells
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https://www.ncbi.nlm.nih.gov/pubmed/20660998
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