Synovial fibroblast-miR-214-3p-derived exosomes inhibit inflammation and degeneration of cartilage tissues of osteoarthritis rats

• Published in: Molecular and cellular biochemistry Vol. 478; no. 3; pp. 637 - 649
• Main Authors: Lai, Chenteng, Liao, Boyi, Peng, Song, Fang, Peng, Bao, Nirong, Zhang, Lei
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2023; Springer; Springer Nature B.V
• Subjects: Animals; Anterior cruciate ligament; Apoptosis; Arthritis; Assaying; Biochemistry; Biomarkers; Biomedical and Life Sciences; Cancer Research; Cardiology; Cartilage; Cartilage (articular); Cartilage diseases; Cartilage, Articular - metabolism; Chondrocytes; Chondrocytes - metabolism; Computed tomography; Degeneration; DNA microarrays; Exosomes; Exosomes - metabolism; Fibroblasts; Fibroblasts - metabolism; Gene expression; Gene flow; In vivo methods and tests; Inflammation; Inflammation - metabolism; Interleukin 6; Life Sciences; Medical Biochemistry; MicroRNAs - genetics; miRNA; Osteoarthritis; Osteoarthritis - pathology; Osteophytes; Physiological aspects; Rats; Synovial fluid; Transmission electron microscopy; Tumor necrosis factor-α; miR-214-3p; Inflammation; Exosomes; Cartilage tissue; Osteoarthritis

MicroRNAs (miRs) are regulators of number of cellular process. miRs enclosed within exosomes can be crucial regulators of intercellular signalling and could be an important biomarker of various age-associated disorders. Role of exosomal enclosed miRs in osteoarthritis (OA) chondrocytes and synovial...