Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec - Hubálek, František; Cramer, Christian N.; Helleberg, Hans; Johansson, Eva; Nishimura, Erica; Schluckebier, Gerd; Steensgaard, Dorte Bjerre; Sturis, Jeppe; Kjeldsen, Thomas B. (Nature communications, 2024)
Keywords: 140/58; 631/154/309/2144; 631/535/1266; 631/92/152; 692/699/2743/137/773; 82/16; Animals; Clearances; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Disulfides; Disulfides - chemistry; Exchanging; Half-Life; Humanities and Social Sciences; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacokinetics; Insulin; Insulin - administration & dosage; Insulin - chemistry; Insulin - metabolism; Insulin - pharmacokinetics; Male; multidisciplinary; Pharmacodynamics; Pharmacokinetics; Receptor, Insulin - metabolism; Receptors; Science; Science (multidisciplinary); Splitting; Stability; Sulfhydryl Compounds - chemistry; Swine; Swine, Miniature