Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system

• Published in: Pflügers Archiv Vol. 474; no. 1; pp. 63 - 81
• Main Authors: Sukumaran, Vijayakumar, Gurusamy, Narasimman, Yalcin, Huseyin C., Venkatesh, Sundararajan
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2022; Springer Nature B.V
• Subjects: Aldosterone; Angiotensin; Angiotensin II - metabolism; Animals; Autophagy; Biomedical and Life Sciences; Biomedicine; Cardiomyocytes; Cardiomyopathy; Cell Biology; Congestive heart failure; Diabetes; Diabetes mellitus; Diabetic Cardiomyopathies - etiology; Diabetic Cardiomyopathies - metabolism; Heart failure; Human Physiology; Humans; Hypertrophy; Inflammation - metabolism; Invited Review; Mitochondria; Molecular Medicine; Morbidity; Neurosciences; Obesity - complications; Obesity - metabolism; Oxidative Stress; Peptidyl-Dipeptidase A - metabolism; Prognosis; Receptors; Receptors, Angiotensin - metabolism; Renin; Renin-Angiotensin System; Ventricle; Diabetic cardiomyopathy; Oxidative stress; Inflammation; Mitochondrial dysfunction; Rennin angiotensin aldosterone system; Autophagy

Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of concomitant micro and macrovascular disorders. DCM is one of the prominent causes o...