Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system

Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of concomitant micro and macrovascular disorders. DCM is one of the prominent causes o...

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Published inPflügers Archiv Vol. 474; no. 1; pp. 63 - 81
Main Authors Sukumaran, Vijayakumar, Gurusamy, Narasimman, Yalcin, Huseyin C., Venkatesh, Sundararajan
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2022
Springer Nature B.V
Subjects
Aldosterone
Angiotensin
Angiotensin II - metabolism
Animals
Autophagy
Biomedical and Life Sciences
Biomedicine
Cardiomyocytes
Cardiomyopathy
Cell Biology
Congestive heart failure
Diabetes
Diabetes mellitus
Diabetic Cardiomyopathies - etiology
Diabetic Cardiomyopathies - metabolism
Heart failure
Human Physiology
Humans
Hypertrophy
Inflammation - metabolism
Invited Review
Mitochondria
Molecular Medicine
Morbidity
Neurosciences
Obesity - complications
Obesity - metabolism
Oxidative Stress
Peptidyl-Dipeptidase A - metabolism
Prognosis
Receptors
Receptors, Angiotensin - metabolism
Renin
Renin-Angiotensin System
Ventricle
Diabetic cardiomyopathy
Oxidative stress
Inflammation
Mitochondrial dysfunction
Rennin angiotensin aldosterone system
Autophagy
Online AccessGet full text

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Abstract Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of concomitant micro and macrovascular disorders. DCM is one of the prominent causes of global morbidity and mortality and is on a rising trend with the increase in the prevalence of diabetes mellitus (DM). DCM is characterized by an early left ventricle diastolic dysfunction associated with the slow progression of cardiomyocyte hypertrophy leading to heart failure, which still has no effective therapy. Although the well-known “Renin Angiotensin Aldosterone System (RAAS)” inhibition is considered a gold-standard treatment in heart failure, its role in DCM is still unclear. At the cellular level of DCM, RAAS induces various secondary mechanisms, adding complications to poor prognosis and treatment of DCM. This review highlights the importance of RAAS signaling and its major secondary mechanisms involving inflammation, oxidative stress, mitochondrial dysfunction, and autophagy, their role in establishing DCM. In addition, studies lacking in the specific area of DCM are also highlighted. Therefore, understanding the complex role of RAAS in DCM may lead to the identification of better prognosis and therapeutic strategies in treating DCM.
AbstractList Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of concomitant micro and macrovascular disorders. DCM is one of the prominent causes of global morbidity and mortality and is on a rising trend with the increase in the prevalence of diabetes mellitus (DM). DCM is characterized by an early left ventricle diastolic dysfunction associated with the slow progression of cardiomyocyte hypertrophy leading to heart failure, which still has no effective therapy. Although the well-known "Renin Angiotensin Aldosterone System (RAAS)" inhibition is considered a gold-standard treatment in heart failure, its role in DCM is still unclear. At the cellular level of DCM, RAAS induces various secondary mechanisms, adding complications to poor prognosis and treatment of DCM. This review highlights the importance of RAAS signaling and its major secondary mechanisms involving inflammation, oxidative stress, mitochondrial dysfunction, and autophagy, their role in establishing DCM. In addition, studies lacking in the specific area of DCM are also highlighted. Therefore, understanding the complex role of RAAS in DCM may lead to the identification of better prognosis and therapeutic strategies in treating DCM.
Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of concomitant micro and macrovascular disorders. DCM is one of the prominent causes of global morbidity and mortality and is on a rising trend with the increase in the prevalence of diabetes mellitus (DM). DCM is characterized by an early left ventricle diastolic dysfunction associated with the slow progression of cardiomyocyte hypertrophy leading to heart failure, which still has no effective therapy. Although the well-known "Renin Angiotensin Aldosterone System (RAAS)" inhibition is considered a gold-standard treatment in heart failure, its role in DCM is still unclear. At the cellular level of DCM, RAAS induces various secondary mechanisms, adding complications to poor prognosis and treatment of DCM. This review highlights the importance of RAAS signaling and its major secondary mechanisms involving inflammation, oxidative stress, mitochondrial dysfunction, and autophagy, their role in establishing DCM. In addition, studies lacking in the specific area of DCM are also highlighted. Therefore, understanding the complex role of RAAS in DCM may lead to the identification of better prognosis and therapeutic strategies in treating DCM.Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy (DCM), which could be an autonomous disease independent of concomitant micro and macrovascular disorders. DCM is one of the prominent causes of global morbidity and mortality and is on a rising trend with the increase in the prevalence of diabetes mellitus (DM). DCM is characterized by an early left ventricle diastolic dysfunction associated with the slow progression of cardiomyocyte hypertrophy leading to heart failure, which still has no effective therapy. Although the well-known "Renin Angiotensin Aldosterone System (RAAS)" inhibition is considered a gold-standard treatment in heart failure, its role in DCM is still unclear. At the cellular level of DCM, RAAS induces various secondary mechanisms, adding complications to poor prognosis and treatment of DCM. This review highlights the importance of RAAS signaling and its major secondary mechanisms involving inflammation, oxidative stress, mitochondrial dysfunction, and autophagy, their role in establishing DCM. In addition, studies lacking in the specific area of DCM are also highlighted. Therefore, understanding the complex role of RAAS in DCM may lead to the identification of better prognosis and therapeutic strategies in treating DCM.
Author Sukumaran, Vijayakumar
Venkatesh, Sundararajan
Gurusamy, Narasimman
Yalcin, Huseyin C.
AuthorAffiliation 3 Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, NJ, USA
1 Biomedical Research Center, Qatar University, Al-Tarfa, 2371 Doha, Qatar
2 Department of Bioscience Research, University of Tennessee Health Science Center, Memphis, TN, USA
AuthorAffiliation_xml – name: 3 Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, NJ, USA
– name: 2 Department of Bioscience Research, University of Tennessee Health Science Center, Memphis, TN, USA
– name: 1 Biomedical Research Center, Qatar University, Al-Tarfa, 2371 Doha, Qatar
Author_xml – sequence: 1
  givenname: Vijayakumar
  surname: Sukumaran
  fullname: Sukumaran, Vijayakumar
  email: vijay@qu.edu.qa, svkumar79@gmail.com
  organization: Biomedical Research Center, Qatar University
– sequence: 2
  givenname: Narasimman
  surname: Gurusamy
  fullname: Gurusamy, Narasimman
  organization: Department of Bioscience Research, University of Tennessee Health Science Center
– sequence: 3
  givenname: Huseyin C.
  surname: Yalcin
  fullname: Yalcin, Huseyin C.
  organization: Biomedical Research Center, Qatar University
– sequence: 4
  givenname: Sundararajan
  surname: Venkatesh
  fullname: Venkatesh, Sundararajan
  organization: Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers-New Jersey Medical School
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34967935$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1210/en.2006-0692
10.1253/circj.CJ-13-1187
10.1042/Bj20090976
10.1152/ajpheart.00796.2011
10.1016/j.euje.2006.09.005
10.1161/HYPERTENSIONAHA.107.089284
10.1161/Hypertensionaha.106.084848
10.1016/j.ymthe.2006.08.009
10.2337/db08-0805
10.1152/physrev.00017.2007
10.1007/s11906-013-0356-1
10.1152/ajpheart.00563.2014
10.1161/Circheartfailure.113.000672
10.1056/NEJMoa1208799
10.1056/NEJM200001203420301
10.3390/ijms161025234
10.1016/j.arcmed.2004.05.003
10.2337/db13-0095
10.1152/ajpheart.00824.2006
10.1093/eurheartj/ehi225
10.1152/ajpheart.00206.2015
10.1161/CIRCULATIONAHA.106.679597
10.1016/S0140-6736(13)62076-0
10.1056/NEJMoa031314.350/7/664[pii]
10.1111/bph.13225
10.1042/CS20120448
10.1016/j.ejphar.2015.03.090
10.1186/1475-2840-12-169
10.1007/s00125-006-0385-2
10.1016/j.jnutbio.2012.04.013
10.1016/j.ejphar.2008.05.024
10.1113/expphysiol.2014.084095
10.1042/CS20130515
10.1152/ajprenal.90308.2008
10.1038/ijo.2009.205
10.1172/JCI29126
10.1177/1358863X12450094
10.1210/en.2006-1691
10.1016/j.freeradbiomed.2014.01.002
10.1002/path.4113
10.1172/JCI25151
10.1038/nature10992
10.1016/S0140-6736(00)02212-1
10.1152/ajpcell.00287.2006
10.2174/1381612811319170009
10.1038/hr.2015.141
10.1007/s00125-017-4390-4
10.1093/cvr/cvp305
10.1016/j.yjmcc.2012.02.001
10.4239/wjd.v6.i7.943
10.1016/j.cardiores.2007.06.022
10.1056/Nejmcp0801652
10.1161/Circresaha.113.301077
10.1152/ajpcell.00069.2015
10.1161/Circulationaha.108.792101
10.1007/s00125-012-2495-3
10.1152/ajpcell.00331.2011
10.1016/j.jacc.2008.05.019
10.1111/j.1476-5381.2010.00750.x
10.1074/jbc.M113.474650
10.1161/HYPERTENSIONAHA.111.179457
10.1016/S0735-1097(03)00625-9
10.1016/j.phrs.2016.02.026
10.1161/HYPERTENSIONAHA.113.01274
10.1016/j.yjmcc.2018.08.028
10.1161/01.cir.96.12.4239
10.1016/j.lfs.2005.12.036
10.1161/01.Hyp.0000251865.35728.2f
10.1161/01.CIR.0000021122.63813.32
10.1146/annurev-physiol-021317-121427
10.1139/Y10-016
10.1161/Circulationaha.106.621854
10.1093/cvr/cvt065
10.2337/db06-1163
10.1038/sj.bjp.0707454
10.1038/nm1574
10.7150/ijbs.7.154
10.1161/Hypertensionaha.112.191650
10.1161/01.CIR.0000147233.10318.23
10.1007/s12272-013-0023-8
10.5740/jaoacint.14-179
10.1161/01.HYP.36.3.360
10.1210/jc.2011-2542
10.7150/ijbs.7.1077
10.1038/hr.2011.105
10.1002/oby.20837
10.2337/db12-0177
10.1042/CS20040057
10.1016/S0140-6736(02)08090-X
10.3389/fendo.2013.00068
10.1161/CIR.0000000000000350
10.1159/000358676
10.1016/j.biomaterials.2013.04.026
10.2337/db06-0288
10.4161/auto.7.10.16740
10.1172/JCI71171
10.1001/archinte.164.16.1737.164/16/1737[pii]
10.1097/01.hjh.0000165623.72310.dd
10.1161/Hypertensionaha.116.07572
10.1038/nrcardio.2014.59
10.1016/j.mce.2011.12.010
10.1161/01.HYP.0000082814.62655.85
10.2337/diabetes.50.6.1414
10.1152/ajpheart.00937.2006
10.1007/s10557-017-6717-2[pii]
10.1016/j.bbadis.2014.06.030
10.1371/journal.pone.0016239
10.3390/ijms140510497
10.1016/j.bcp.2011.11.018
10.1161/01.HYP.0000157169.27818.ae
10.4061/2011/685238
10.1016/j.intimp.2007.06.012
10.1016/j.diabres.2013.11.002
10.4161/auto.5.8.10153
10.1080/15548627.2015.1051295
10.4196/kjpp.2014.18.1.1
10.1016/j.yexcr.2014.03.006
10.1161/CIRCRESAHA.107.162800
10.1016/j.regpep.2010.07.165
10.3390/nu5093757
10.1016/j.yexcr.2012.02.023
10.1007/s11892-010-0163-x
10.1161/Circulationaha.115.020502
10.1016/j.diabres.2008.09.017
10.1161/01.RES.87.12.1123
10.1089/ars.2013.5302
10.1016/j.jacc.2010.07.033
10.1161/01.CIR.95.5.1247
10.1161/01.HYP.35.6.1183
10.1152/ajprenal.00503.2009
10.1097/01.fjc.0000245405.41317.60
10.3389/fcell.2014.00073
10.1074/jbc.M113.459792
10.1016/j.cardiores.2004.12.026
10.1172/JCI36703
10.1530/Joe-12-0341
10.1007/s00109-003-0450-y
10.1016/j.jacc.2013.05.019
10.1016/j.cardiores.2007.04.007
10.18553/jmcp.2007.13.s8-b
10.1161/HYPERTENSIONAHA.110.162339
10.1007/s12012-015-9321-3
10.1161/HYPERTENSIONAHA.108.128488
10.3390/ijms141121525
10.1161/CIRCRESAHA.118.312208
10.1161/Hypertensionaha.108.114280
10.1097/00019501-200511001-00002
10.1073/pnas.0903485106
10.1016/0002-9149(91)90716-X
10.1038/hr.2011.173
10.1177/1753944711409281
10.1210/er.2003-0012.25/4/543[pii]
10.1016/j.bbrc.2013.09.086
10.4239/wjd.v5.i4.444
10.5049/EBP.2008.6.1.42
10.1016/j.amjcard.2005.11.010
10.1006/jmcc.1996.0080
10.1161/Circheartfailure.108.840124
10.1016/j.echo.2009.03.028
10.1371/journal.pone.0081296
10.1097/Fjc.0b013e31802b31a7
10.1152/ajpheart.01307.2005
10.1111/j.1582-4934.2008.00547.x
10.1161/01.Res.0000126501.34994.96
10.2337/db15-0399
10.1016/j.atherosclerosis.2012.11.018
10.1038/nrendo.2015.216
10.5812/cardiovascmed.4(2)2015.26949
10.1152/ajpheart.00372.2006
10.1007/s00125-016-3977-5
10.1007/s11154-010-9131-7
10.1016/j.ejphar.2010.10.081
10.1007/s10741-012-9313-3
10.1152/ajpheart.01395.2006
10.1152/ajpendo.90678.2008
10.1093/ndt/gfn357
10.1016/j.cardfail.2014.02.007
10.1136/hrt.2006.101667
10.1172/Jci117243
10.1001/archinternmed.2009.21
10.2337/db09-0934
10.1016/j.regpep.2010.02.001
10.1007/s00592-018-1220-1
10.1016/j.jacc.2009.07.031
10.1146/annurev-physiol-021909-135846
10.1161/01.RES.0000130944.49657.b8
10.1016/j.ejps.2012.04.018
10.3164/jcbn.11-012FR
10.3349/ymj.2012.53.2.294
10.1038/35022604
10.1111/jcmm.12687
10.1080/15548627.2016.1145326
10.1161/CIRCULATIONAHA.116.022194
10.1038/hr.2011.157
10.1159/000064682
10.1093/eurjhf/hfq022
10.1161/Atvbaha.116.307518
10.1253/circj.CJ-08-0014
10.1136/bmj.b688
10.1371/journal.pone.0056803
10.1186/1475-2891-12-89
10.1371/journal.pone.0068697
10.1002/14651858.Cd009671.Pub2
10.1371/journal.pone.0138609
10.1155/2013/716219
10.3317/jraas.2004.041
10.1016/S0140-6736(99)12323-7
10.1371/journal.pone.0012323
10.3389/Fphar.2016.00024
10.1186/1475-2840-8-58
10.1155/2015/981242
10.1371/journal.pone.0093145
ContentType Journal Article
Copyright The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021
2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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1432-2013
IngestDate Thu Aug 21 18:37:20 EDT 2025
Fri Jul 11 11:27:22 EDT 2025
Wed Aug 13 08:53:32 EDT 2025
Sun Jun 01 01:35:32 EDT 2025
Tue Jul 01 02:55:15 EDT 2025
Thu Apr 24 23:10:38 EDT 2025
Fri Feb 21 02:46:32 EST 2025
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Issue 1
Keywords Diabetic cardiomyopathy
Oxidative stress
Inflammation
Mitochondrial dysfunction
Rennin angiotensin aldosterone system
Autophagy
Language English
License 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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PublicationSubtitle Official Journal of the German Physiological Society
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References van Thiel, van der Pluijm, Riet, Essers, Danser (CR188) 2015; 763
Neri Serneri, Boddi, Modesti, Coppo, Cecioni, Toscano, Papa, Bandinelli, Lisi, Chiavarelli (CR124) 2004; 94
Tziakas, Chalikias, Kaski (CR186) 2005; 16
Fang, Prins, Marwick (CR49) 2004; 25
Diamant, Lamb, Groeneveld, Endert, Smit, Bax, Romijn, de Roos, Radder (CR39) 2003; 42
Lautner, Villela, Fraga-Silva, Silva, Verano-Braga, Costa-Fraga, Jankowski, Jankowski, Sousa, Alzamora, Soares, Barbosa, Kjeldsen, Oliveira, Braga, Savergnini, Maia, Peluso, Passos-Silva, Ferreira, Alves, Martins, Raizada, Paula, Motta-Santos, Kemplin, Pimenta, Alenina, Sinisterra, Bader, Campagnole-Santos, Santos (CR93) 2013; 112
Riehle, Wende, Sena, Pires, Pereira, Zhu, Bugger, Frank, Bevins, Chen, Perry, Dong, Valdez, Rech, Sheng, Weimer, Gottlieb, White, Abel (CR147) 2013; 123
Fenger (CR50) 2013; 227
Benigni, Corna, Zoja, Sonzogni, Latini, Salio, Conti, Rottoli, Longaretti, Cassis, Morigi, Coffman, Remuzzi (CR11) 2009; 119
Lohmeier, Iliescu (CR99) 2013; 15
Finckenberg, Eriksson, Baumann, Merasto, Lalowski, Levijoki, Haasio, Kyto, Muller, Luft, Oresic, Mervaala (CR51) 2012; 59
Shirakabe, Zhai, Ikeda, Saito, Maejima, Hsu, Nomura, Egashira, Levine, Sadoshima (CR161) 2016; 133
Watanabe, Suzuki, Wakayama, Kumagai, Ikeda, Akazawa, Komuro, Isobe (CR193) 2016; 39
Symeonides, Koulouris, Vratsista, Triantafyllou, Ioannidis, Thalassinos, Katritsis (CR176) 2007; 8
Karam, McFarlane (CR83) 2011; 11
Matsusaka, Kinugawa, Ide, Matsushima, Shiomi, Kubota, Sunagawa, Tsutsui (CR109) 2006; 48
Schannwell, Schneppenheim, Perings, Plehn, Strauer (CR157) 2002; 98
Amador, Encarnacion, Rodriguez, Tello, Lopez, Guizar (CR4) 2004; 35
Dzau (CR45) 2005; 23
Martin-Timon, Sevillano-Collantes, Segura-Galindo, Del Canizo-Gomez (CR108) 2014; 5
Low Wang, Hess, Hiatt, Goldfine (CR100) 2016; 133
Naito, Ma, Yang, Zuo, Tang, Han, Kon, Fogo (CR120) 2010; 298
Oak, Cai (CR127) 2007; 56
Lim, MacFadyen, Lip (CR96) 2004; 164
Morino, Petersen, Dufour, Befroy, Frattini, Shatzkes, Neschen, White, Bilz, Sono, Pypaert, Shulman (CR114) 2005; 115
Dai, Xu, Yao, Sun (CR29) 2007; 152
Yusuf, Sleight, Pogue, Bosch, Davies, Dagenais (CR211) 2000; 342
Hao, Yang, Zhang, Zhang, Chen, Zhang, Zhang (CR68) 2015; 308
Patel, Mori, McLean, Basu, Das, Ramprasath, Parajuli, Penninger, Grant, Lopaschuk, Oudit (CR135) 2016; 65
Zhang, Shadrin, Lam, Xian, Snodgrass, Bursac (CR212) 2013; 34
Qi, Xu, Zhu, Thomas, Kumar, Feng, Dostal, White, Baker, Guo (CR144) 2013; 62
Tsutsui, Kinugawa, Matsushima, Yokota (CR185) 2011; 48
Oka, Hikoso, Yamaguchi, Taneike, Takeda, Tamai, Oyabu, Murakawa, Nakayama, Nishida, Akira, Yamamoto, Komuro, Otsu (CR128) 2012; 485
Hussein, El-Wadood, Abdallah, Khorshed (CR71) 2015; 98
Papinska, Mordwinkin, Meeks, Jadhav, Rodgers (CR131) 2015; 172
Mariappan, Elks, Sriramula, Guggilam, Liu, Borkhsenious, Francis (CR107) 2010; 85
CR139
Candido, Jandeleit-Dahm, Cao, Nesteroff, Burns, Twigg, Dilley, Cooper, Allen (CR19) 2002; 106
Jiang, Yang, Zhang, Dong, Wang, Zhang, Liu, Zhang, Zhang (CR77) 2014; 11
Fiordaliso, Cuccovillo, Bianchi, Bai, Doni, Salio, De Angelis, Ghezzi, Latini, Masson (CR52) 2006; 79
Gao, Tsai, Al-Sharea, Su, Moore, Han, Kiriazis, Dart, Murphy, Du (CR58) 2017; 31
Kalil, Haynes (CR81) 2012; 35
Ma, Kam, Yan, Lam (CR103) 2010; 160
CR146
Savini, Catani, Evangelista, Gasperi, Avigliano (CR156) 2013; 14
Takeda, Yamamoto, Takemura, Takeshita, Hongyo, Kawai, Hanasaki-Yamamoto, Oguro, Takami, Tatara, Takeya, Sugimoto, Kamide, Ohishi, Rakugi (CR178) 2013; 62
Thomas, Yong, Seqqat, Chandel, Feldman, Baker, Kumar (CR183) 2013; 124
Nishino, Fu, Tanji, Yamada, Shimojo, Koori, Mora, Riggs, Oh, Koga, Sue, Yamamoto, Murakami, Shanske, Byrne, Bonilla, Nonaka, DiMauro, Hirano (CR125) 2000; 406
Watanabe, Nagai, Takatsu (CR194) 2013; 5
Ha, Hwang, Park, Lee (CR65) 2008; 82
Kim, Iwao (CR87) 2000; 52
Chow, Koulis, Krishnaswamy, Steckelings, Unger, Cooper, Jandeleit-Dahm, Allen (CR24) 2016; 59
Zhao, Ahokas, Weber, Sun (CR214) 2006; 291
Yokoyama, Nakano, Bednarczyk, McIntyre, Entman, Mann (CR207) 1997; 95
Fukuda, Ahearn, Roberts, Mattaliano, Zaal, Ralston, Plotz, Raben (CR55) 2006; 14
Mozaffarian, Kamineni, Carnethon, Djousse, Mukamal, Siscovick (CR116) 2009; 169
Russo, Jin, Homma, Rundek, Elkind, Sacco, Di Tullio (CR149) 2010; 12
Connelly, Kelly, Zhang, Prior, Martin, Cox, Thai, Feneley, Tsoporis, White, Krum, Gilbert (CR25) 2007; 76
Stiefel, Vallejo-Vaz, Garcia Morillo, Villar (CR168) 2011; 2011
Andreozzi, Laratta, Sciacqua, Perticone, Sesti (CR6) 2004; 94
Sukumaran, Veeraveedu, Gurusamy, Lakshmanan, Yamaguchi, Ma, Suzuki, Nagata, Takagi, Kodama, Watanabe (CR171) 2012; 351
Zhou, Schulman, Zeng (CR217) 2012; 17
Tassone, Sciacqua, Andreozzi, Presta, Perticone, Carnevale, Casaburo, Hribal, Sesti, Perticone (CR179) 2013; 99
Flather, Yusuf, Kober, Pfeffer, Hall, Murray, Torp-Pedersen, Ball, Pogue, Moye, Braunwald, C AIMI (CR53) 2000; 355
Patel, Bodiga, Fan, Das, Wang, Wang, Basu, Zhong, Kassiri, Oudit (CR134) 2012; 59
Ansley, Wang (CR7) 2013; 229
Porrello, D'Amore, Curl, Allen, Harrap, Thomas, Delbridge (CR140) 2009; 53
Willemsen, Westerink, Dallinga-Thie, van Zonneveld, Gaillard, Rabelink, de Koning (CR198) 2007; 49
Yancy, Jessup, Bozkurt, Butler, Casey, Drazner, Fonarow, Geraci, Horwich, Januzzi, Johnson, Kasper, Levy, Masoudi, McBride, McMurray, Mitchell, Peterson, Riegel, Sam, Stevenson, Tang, Tsai, Wilkoff, Anderson, Jacobs, Halperin, Albert, Bozkurt, Brindis, Creager, Curtis, DeMets, Guyton, Hochman, Kovacs, Kushner, Ohman, Pressler, Sellke, Shen, Stevenson, Commi, Force (CR202) 2013; 62
CR121
Nakai, Yamaguchi, Takeda, Higuchi, Hikoso, Taniike, Omiya, Mizote, Matsumura, Asahi, Nishida, Hori, Mizushima, Otsu (CR122) 2007; 13
Waddingham, Edgley, Tsuchimochi, Kelly, Shirai, Pearson (CR191) 2015; 6
Doughan, Harrison, Dikalov (CR43) 2008; 102
Yayama, Okamoto (CR204) 2008; 8
Teshima, Takahashi, Nishio, Saito, Kondo, Fukui, Aoki, Yufu, Nakagawa, Saikawa (CR180) 2014; 78
Mozaffarian, Benjamin, Go, Arnett, Blaha, Cushman, Das, de Ferranti, Despres, Fullerton, Howard, Huffman, Isasi, Jimenez, Judd, Kissela, Lichtman, Lisabeth, Liu, Mackey, Magid, McGuire, Mohler, Moy, Muntner, Mussolino, Nasir, Neumar, Nichol, Palaniappan, Pandey, Reeves, Rodriguez, Rosamond, Sorlie, Stein, Towfighi, Turan, Virani, Woo, Yeh, Turner (CR115) 2016; 133
Varga, Giricz, Liaudet, Hasko, Ferdinandy, Pacher (CR189) 2015; 1852
CR18
Kadoguchi, Kinugawa, Takada, Fukushima, Furihata, Homma, Masaki, Mizushima, Nishikawa, Takahashi, Yokota, Matsushima, Okita, Tsutsui (CR78) 2015; 100
Sampaio, dos Santos, Faria-Silva, Machado, Schiffrin, Touyz (CR152) 2007; 49
Giani, Gironacci, Munoz, Pena, Turyn, Dominici (CR60) 2007; 293
CR213
Miki, Yuda, Kouzu, Miura (CR111) 2013; 18
Kajstura, Fiordaliso, Andreoli, Li, Chimenti, Medow, Limana, Nadal-Ginard, Leri, Anversa (CR80) 2001; 50
Yu, Chen, Liang, Lin, Tan, Fu, Liu, Shan, Li, Yang, Yang, Li, Lin (CR210) 2011; 6
Banday, Lokhandwala (CR10) 2011; 57
Mehta, Griendling (CR110) 2007; 292
Eckel (CR47) 2008; 358
Yim, Yoo (CR206) 2008; 6
CR26
Privratsky, Wold, Sowers, Quinn, Ren (CR142) 2003; 42
Rajesh, Mukhopadhyay, Batkai, Patel, Saito, Matsumoto, Kashiwaya, Horvath, Mukhopadhyay, Becker, Hasko, Liaudet, Wink, Veves, Mechoulam, Pacher (CR145) 2010; 56
CR101
Benter, Yousif, Cojocel, Al-Maghrebi, Diz (CR12) 2007; 292
Daly, Fox, Remme, Bertrand, Ferrari, Simoons (CR30) 2005; 26
Sukumaran, Watanabe, Veeraveedu, Gurusamy, Ma, Thandavarayan, Lakshmanan, Yamaguchi, Suzuki, Kodama (CR172) 2011; 7
Frustaci, Kajstura, Chimenti, Jakoniuk, Leri, Maseri, Nadal-Ginard, Anversa (CR54) 2000; 87
Bugger, Riehle, Jaishy, Wende, Tuinei, Chen, Soto, Pires, Boudina, Theobald, Luptak, Wayment, Wang, Litwin, Weimer, Abel (CR16) 2012; 52
Westermann, Rutschow, Van Linthout, Linderer, Bucker-Gartner, Sobirey, Riad, Pauschinger, Schultheiss, Tschope (CR197) 2006; 49
Crabos, Roth, Hahn, Erne (CR27) 1994; 93
Xie, He, Zou (CR199) 2011; 7
Abdellatif, Sedej, Carmona-Gutierrez, Madeo, Kroemer (CR1) 2018; 123
Sciarretta, Maejima, Zablocki, Sadoshima (CR158) 2018; 80
Shahveisi, Mousavi, Hosseini, Rad, Jalali, Rajaei, Sadeghnia, Hadjzadeh (CR160) 2014; 17
Singh, Le, Khode, Baker, Kumar (CR164) 2008; 57
Cheng, Zhang, Hu, Lin, Feng, Wang, Wang, Gao, Wang, Sun (CR23) 2018; 125
De Mello (CR34) 2014; 323
Santos, Ferreira, Verano-Braga, Bader (CR154) 2013; 216
Di Marco, Gray, Jandeleit-Dahm (CR38) 2013; 4
Montezano, Touyz (CR112) 2014; 20
CR33
Mori, Patel, Alrob, Basu, Altamimi, DesAulniers, Wagg, Kassiri, Lopaschuk, Oudit (CR113) 2014; 7
Xu, Kobayashi, Chen, Timm, Volden, Huang, Gulick, Yue, Robbins, Epstein, Liang (CR201) 2013; 288
Soetikno, Sari, Sukumaran, Lakshmanan, Mito, Harima, Thandavarayan, Suzuki, Nagata, Takagi, Watanabe (CR166) 2012; 47
Wang, Lu, Hao, Li, Wang, Wang, Yan, Zhang, Du, Liu (CR192) 2013; 8
Kanamori, Takemura, Goto, Tsujimoto, Mikami, Ogino, Watanabe, Morishita, Okada, Kawasaki, Seishima, Minatoguchi (CR82) 2015; 11
Huynh, Kiriazis, Du, Love, Jandeleit-Dahm, Forbes, McMullen, Ritchie (CR72) 2012; 55
Olefsky, Glass (CR129) 2010; 72
Anderson, Kypson, Rodriguez, Anderson, Lehr, Neufer (CR5) 2009; 54
Sun, Weber (CR175) 1996; 28
Lin, Liu, Xu, Weng, Ren, Ge, Zou (CR97) 2016; 20
Chen, Chen, Xiao, Wu, Wang, Sun, Fu, Mou, Tao, Hu, Hu (CR21) 2014; 33
Ha, Lee, Kang, Ahn, Kim, Ahn, Lee, Choi, Rim, Oh, Chung (CR66) 2007; 93
CR48
Lee (CR94) 2013; 36
Sampaio, de Castro, Santos, Schiffrin, Touyz (CR151) 2007; 50
CR44
Lakshmanan, Harima, Sukumaran, Soetikno, Thandavarayan, Suzuki, Kodama, Nagata, Takagi, Watanabe (CR92) 2012; 83
CR41
CR200
Donath, Storling, Maedler, Mandrup-Poulsen (CR42) 2003; 81
Sun, Dawood, Wen, Chen, Dixon, Kirshenbaum, Liu (CR174) 2004; 110
Van Gaal, Maggioni (CR187) 2014; 383
CR205
Hayat, Patel, Khattar, Malik (CR69) 2004; 107
Boudina, Abel (CR14) 2010; 11
Boudina, Abel (CR13) 2007; 115
CR57
Takahashi, Yoshika, Komiyama, Nishimura (CR177) 2011; 34
Parving, Brenner, McMurray, de Zeeuw, Haffner, Solomon, Chaturvedi, Persson, Desai, Nicolaides, Richard, Xiang, Brunel, Pfeffer (CR133) 2012; 367
Ebermann, Spillmann, Sidiropoulos, Escher, Heringer-Walther, Schultheiss, Tschope, Walther (CR46) 2008; 5
2651_CR139
J Kajstura (2651_CR80) 2001; 50
PP Hao (2651_CR68) 2015; 308
RAS Santos (2651_CR154) 2013; 216
H Kanamori (2651_CR82) 2015; 11
GN Shah (2651_CR159) 2013; 440
MF Dias-Peixoto (2651_CR40) 2008; 52
D Mozaffarian (2651_CR116) 2009; 169
R Candido (2651_CR19) 2002; 106
P Stiefel (2651_CR168) 2011; 2011
DN Tziakas (2651_CR186) 2005; 16
MT Waddingham (2651_CR191) 2015; 6
K Shahveisi (2651_CR160) 2014; 17
XM Xu (2651_CR201) 2013; 288
SM Haffner (2651_CR67) 2006; 97
EJ Anderson (2651_CR5) 2009; 54
M Fenger (2651_CR50) 2013; 227
KF Petersen (2651_CR137) 2004; 350
V Dzau (2651_CR45) 2005; 23
M Abdellatif (2651_CR1) 2018; 123
PK Mehta (2651_CR110) 2007; 292
M Satoh (2651_CR155) 2008; 23
M Crabos (2651_CR27) 1994; 93
P Finckenberg (2651_CR51) 2012; 59
Y Qi (2651_CR144) 2013; 62
J Lee (2651_CR94) 2013; 36
KA Connelly (2651_CR25) 2007; 76
2651_CR121
D Westermann (2651_CR196) 2007; 56
D Zhang (2651_CR212) 2013; 34
CW Younce (2651_CR209) 2010; 426
T Yokoyama (2651_CR207) 1997; 95
EJ Tassone (2651_CR179) 2013; 99
T Miki (2651_CR111) 2013; 18
CA Daly (2651_CR30) 2005; 26
C Riehle (2651_CR147) 2013; 123
JW Ha (2651_CR66) 2007; 93
D Villela (2651_CR190) 2015; 128
S Dandamudi (2651_CR31) 2014; 20
S Stas (2651_CR167) 2007; 148
SA Atlas (2651_CR8) 2007; 13
ZV Varga (2651_CR189) 2015; 1852
AK Doughan (2651_CR43) 2008; 102
SD Crowley (2651_CR28) 2012; 318
A Frustaci (2651_CR54) 2000; 87
L Wang (2651_CR192) 2013; 8
TE Lohmeier (2651_CR99) 2013; 15
GG Neri Serneri (2651_CR124) 2004; 94
S Boudina (2651_CR15) 2009; 119
JL Grobe (2651_CR63) 2007; 292
Y Kayama (2651_CR85) 2015; 16
2651_CR101
VP Singh (2651_CR163) 2014; 18
Q Dai (2651_CR29) 2007; 152
RM Maalouf (2651_CR104) 2012; 302
V Soetikno (2651_CR166) 2012; 47
WC De Mello (2651_CR35) 2000; 35
F Jiang (2651_CR77) 2014; 11
L Ebermann (2651_CR46) 2008; 590
D Pitocco (2651_CR138) 2013; 14
G Deng (2651_CR37) 2010; 34
AM Papinska (2651_CR132) 2016; 107
N Amador (2651_CR4) 2004; 35
RA Santos (2651_CR153) 2014; 63
W Zhao (2651_CR214) 2006; 291
ZY Fang (2651_CR49) 2004; 25
HS Lim (2651_CR96) 2004; 164
I Nishino (2651_CR125) 2000; 406
WC De Mello (2651_CR36) 2010; 165
YL Gao (2651_CR59) 2016; 16
2651_CR26
E Di Marco (2651_CR38) 2013; 4
2651_CR184
JF Giani (2651_CR60) 2007; 293
XY Yu (2651_CR210) 2011; 6
RH Eckel (2651_CR47) 2008; 358
L Lin (2651_CR97) 2016; 20
WO Sampaio (2651_CR152) 2007; 49
2651_CR18
VB Patel (2651_CR135) 2016; 65
T Fukuda (2651_CR55) 2006; 14
S Boudina (2651_CR13) 2007; 115
ER Porrello (2651_CR141) 2009; 5
M Takeda (2651_CR178) 2013; 62
R Watanabe (2651_CR193) 2016; 39
J Mori (2651_CR113) 2014; 7
M Galderisi (2651_CR56) 1991; 68
TL Kleinschmidt (2651_CR89) 2014; 22
T Kadoguchi (2651_CR78) 2015; 100
D Westermann (2651_CR197) 2006; 49
M Khullar (2651_CR86) 2010; 88
G Castoldi (2651_CR20) 2019; 56
F Chen (2651_CR21) 2014; 33
M de Gasparo (2651_CR32) 2000; 52
K Singh (2651_CR162) 2011; 5
H Bugger (2651_CR16) 2012; 52
E Bush (2651_CR17) 2000; 36
AC Montezano (2651_CR112) 2014; 20
K Putnam (2651_CR143) 2012; 302
S Kim (2651_CR87) 2000; 52
2651_CR146
S Yusuf (2651_CR211) 2000; 342
A Makino (2651_CR105) 2015; 309
GY Oudit (2651_CR130) 2007; 75
G Jia (2651_CR76) 2018; 61
T Kadowaki (2651_CR79) 2006; 116
LH Lindholm (2651_CR98) 2002; 359
N Yaras (2651_CR203) 2007; 292
JR Privratsky (2651_CR142) 2003; 42
CM Schannwell (2651_CR157) 2002; 98
G Zhou (2651_CR216) 2008; 52
C Russo (2651_CR149) 2010; 12
SB Kritchevsky (2651_CR91) 2005; 66
JM Olefsky (2651_CR129) 2010; 72
H Matsusaka (2651_CR109) 2006; 48
Z Cheng (2651_CR23) 2018; 125
S Sciarretta (2651_CR158) 2018; 80
JF Giani (2651_CR61) 2009; 296
H Kobori (2651_CR90) 2013; 19
I Savini (2651_CR156) 2013; 14
V Sukumaran (2651_CR172) 2011; 7
V Soetikno (2651_CR165) 2013; 24
V Sukumaran (2651_CR173) 2011; 652
SQ Lei (2651_CR95) 2012; 53
RF Mapanga (2651_CR106) 2016; 310
V Sukumaran (2651_CR171) 2012; 351
VB Patel (2651_CR134) 2012; 59
HE Yim (2651_CR206) 2008; 6
2651_CR57
T Murase (2651_CR119) 2012; 35
CM Thomas (2651_CR183) 2013; 124
S Boudina (2651_CR14) 2010; 11
CW Yancy (2651_CR202) 2013; 62
G Zuanetti (2651_CR218) 1997; 96
AP Lakshmanan (2651_CR92) 2012; 83
J Jager (2651_CR74) 2007; 148
M Diamant (2651_CR39) 2003; 42
H Ma (2651_CR102) 2009; 13
2651_CR48
V Sukumaran (2651_CR170) 2011; 7
QC Yong (2651_CR208) 2013; 12
2651_CR44
2651_CR41
G Jia (2651_CR75) 2016; 12
W Zhao (2651_CR215) 2014; 69
LF Van Gaal (2651_CR187) 2014; 383
T Naito (2651_CR120) 2010; 298
Z Muhammad (2651_CR117) 2013; 23
M Sun (2651_CR174) 2004; 110
WC De Mello (2651_CR34) 2014; 323
TK Ma (2651_CR103) 2010; 160
AA Banday (2651_CR10) 2011; 57
JH Oak (2651_CR127) 2007; 56
A Tetzner (2651_CR181) 2016; 68
2651_CR33
MY Donath (2651_CR42) 2003; 81
AV Nosarev (2651_CR126) 2014; 2
H Ha (2651_CR65) 2008; 82
Z Kassiri (2651_CR84) 2009; 2
A Than (2651_CR182) 2013; 288
JM Willemsen (2651_CR198) 2007; 49
ER Porrello (2651_CR140) 2009; 53
P Symeonides (2651_CR176) 2007; 8
BS van Thiel (2651_CR188) 2015; 763
DM Ansley (2651_CR7) 2013; 229
A Nenna (2651_CR123) 2015; 4
K Morino (2651_CR114) 2005; 115
2651_CR213
VP Singh (2651_CR164) 2008; 57
AA Banday (2651_CR9) 2008; 295
SA Hussein (2651_CR71) 2015; 98
J Cheng (2651_CR22) 2015; 23
NE Straznicky (2651_CR169) 2010; 59
2651_CR205
WO Sampaio (2651_CR151) 2007; 50
F Fiordaliso (2651_CR52) 2006; 79
2651_CR200
T Saito (2651_CR150) 2016; 12
RI Pereira (2651_CR136) 2012; 97
Y Teshima (2651_CR180) 2014; 78
A Shirakabe (2651_CR161) 2016; 133
JG Karam (2651_CR83) 2011; 11
M Rajesh (2651_CR145) 2010; 56
T Oka (2651_CR128) 2012; 485
IF Benter (2651_CR12) 2007; 292
S Kimura (2651_CR88) 2005; 45
A Goldin (2651_CR62) 2006; 114
HH Parving (2651_CR133) 2012; 367
L Guariguata (2651_CR64) 2014; 103
CC Low Wang (2651_CR100) 2016; 133
SA Hayat (2651_CR69) 2004; 107
M Ristow (2651_CR148) 2009; 106
H Takahashi (2651_CR177) 2011; 34
A Nakai (2651_CR122) 2007; 13
ED Abel (2651_CR2) 2008; 88
N Mariappan (2651_CR107) 2010; 85
Y Sun (2651_CR175) 1996; 28
ZL Xie (2651_CR199) 2011; 7
K Yayama (2651_CR204) 2008; 8
K Huynh (2651_CR72) 2012; 55
BSM Chow (2651_CR24) 2016; 59
H Tsutsui (2651_CR185) 2011; 48
F Andreozzi (2651_CR6) 2004; 94
G Acar (2651_CR3) 2009; 22
XM Gao (2651_CR58) 2017; 31
A Benigni (2651_CR11) 2009; 119
GZ Kalil (2651_CR81) 2012; 35
AM Papinska (2651_CR131) 2015; 172
I Martin-Timon (2651_CR108) 2014; 5
H Ibsen (2651_CR73) 2003; 165
RQ Lautner (2651_CR93) 2013; 112
MS Zhou (2651_CR217) 2012; 17
MC Munoz (2651_CR118) 2010; 161
MD Flather (2651_CR53) 2000; 355
2651_CR70
Y Wei (2651_CR195) 2007; 50
D Mozaffarian (2651_CR115) 2016; 133
Y Watanabe (2651_CR194) 2013; 5
References_xml – volume: 148
  start-page: 241
  year: 2007
  end-page: 251
  ident: CR74
  article-title: Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
  publication-title: Endocrinology
  doi: 10.1210/en.2006-0692
– volume: 78
  start-page: 300
  year: 2014
  end-page: 306
  ident: CR180
  article-title: Production of reactive oxygen species in the diabetic heart - roles of mitochondria and NADPH oxidase -
  publication-title: Circ J
  doi: 10.1253/circj.CJ-13-1187
– volume: 426
  start-page: 43
  year: 2010
  end-page: 53
  ident: CR209
  article-title: MCP-1 causes cardiomyoblast death via autophagy resulting from ER stress caused by oxidative stress generated by inducing a novel zinc-finger protein, MCPIP
  publication-title: Biochem J
  doi: 10.1042/Bj20090976
– volume: 302
  start-page: H1219
  year: 2012
  end-page: H1230
  ident: CR143
  article-title: The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome
  publication-title: Am J Physiol-Heart Circ Physiol
  doi: 10.1152/ajpheart.00796.2011
– volume: 8
  start-page: 480
  year: 2007
  end-page: 486
  ident: CR176
  article-title: Both ramipril and telmisartan reverse indices of early diabetic cardiomyopathy: a comparative study
  publication-title: Eur J Echocardiogr
  doi: 10.1016/j.euje.2006.09.005
– volume: 50
  start-page: 384
  year: 2007
  end-page: 391
  ident: CR195
  article-title: NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.107.089284
– volume: 50
  start-page: 1093
  year: 2007
  end-page: 1098
  ident: CR151
  article-title: Angiotensin-(1–7) counterregulates angiotensin II signaling in human endothelial cells
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.106.084848
– volume: 14
  start-page: 831
  year: 2006
  end-page: 839
  ident: CR55
  article-title: Autophagy and mistargeting of therapeutic enzyme in skeletal muscle in Pompe disease
  publication-title: Mol Ther
  doi: 10.1016/j.ymthe.2006.08.009
– volume: 57
  start-page: 3297
  year: 2008
  end-page: 3306
  ident: CR164
  article-title: Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis
  publication-title: Diabetes
  doi: 10.2337/db08-0805
– volume: 88
  start-page: 389
  year: 2008
  end-page: 419
  ident: CR2
  article-title: Cardiac remodeling in obesity
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00017.2007
– volume: 15
  start-page: 409
  year: 2013
  end-page: 416
  ident: CR99
  article-title: The sympathetic nervous system in obesity hypertension
  publication-title: Curr Hypertens Rep
  doi: 10.1007/s11906-013-0356-1
– volume: 308
  start-page: H1007
  year: 2015
  end-page: 1019
  ident: CR68
  article-title: Angiotensin-(1–7) treatment mitigates right ventricular fibrosis as a distinctive feature of diabetic cardiomyopathy
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00563.2014
– volume: 7
  start-page: 327
  year: 2014
  end-page: 339
  ident: CR113
  article-title: Angiotensin 1–7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db/db mice by reducing lipotoxicity and inflammation
  publication-title: Circulation-Heart Failure
  doi: 10.1161/Circheartfailure.113.000672
– ident: CR121
– volume: 367
  start-page: 2204
  year: 2012
  end-page: 2213
  ident: CR133
  article-title: Cardiorenal end points in a trial of aliskiren for type 2 diabetes
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1208799
– volume: 342
  start-page: 145
  year: 2000
  end-page: 153
  ident: CR211
  article-title: Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients
  publication-title: N Engl J Med
  doi: 10.1056/NEJM200001203420301
– volume: 16
  start-page: 25234
  year: 2015
  end-page: 25263
  ident: CR85
  article-title: Diabetic cardiovascular disease induced by oxidative stress
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms161025234
– volume: 35
  start-page: 411
  year: 2004
  end-page: 415
  ident: CR4
  article-title: Relationship between left ventricular mass and heart sympathetic activity in male obese subjects
  publication-title: Arch Med Res
  doi: 10.1016/j.arcmed.2004.05.003
– volume: 17
  start-page: 613
  year: 2014
  end-page: 621
  ident: CR160
  article-title: The role of local renin-angiotensin system on high glucose-induced cell toxicity, apoptosis and reactive oxygen species production in PC12 cells
  publication-title: Iran J Basic Med Sci
– volume: 62
  start-page: 3887
  year: 2013
  end-page: 3900
  ident: CR144
  article-title: Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38alpha MAPK during insulin resistance
  publication-title: Diabetes
  doi: 10.2337/db13-0095
– volume: 292
  start-page: H912
  year: 2007
  end-page: 920
  ident: CR203
  article-title: Restoration of diabetes-induced abnormal local Ca2+ release in cardiomyocytes by angiotensin II receptor blockade
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00824.2006
– volume: 26
  start-page: 1369
  year: 2005
  end-page: 1378
  ident: CR30
  article-title: The effect of perindopril on cardiovascular morbidity and mortality in patients with diabetes in the EUROPA study: results from the PERSUADE substudy
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehi225
– ident: CR57
– volume: 310
  start-page: H153
  year: 2016
  end-page: H173
  ident: CR106
  article-title: Damaging effects of hyperglycemia on cardiovascular function: spotlight on glucose metabolic pathways
  publication-title: American Journal of Physiology-Heart and Circulatory Physiology
  doi: 10.1152/ajpheart.00206.2015
– volume: 115
  start-page: 3213
  year: 2007
  end-page: 3223
  ident: CR13
  article-title: Diabetic cardiomyopathy revisited
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.679597
– volume: 383
  start-page: 935
  year: 2014
  end-page: 936
  ident: CR187
  article-title: Overweight, obesity, and outcomes: fat mass and beyond
  publication-title: Lancet
  doi: 10.1016/S0140-6736(13)62076-0
– volume: 350
  start-page: 664
  year: 2004
  end-page: 671
  ident: CR137
  article-title: Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa031314.350/7/664[pii]
– volume: 172
  start-page: 4443
  year: 2015
  end-page: 4453
  ident: CR131
  article-title: Angiotensin-(1–7) administration benefits cardiac, renal and progenitor cell function in db/db mice
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13225
– volume: 124
  start-page: 529
  year: 2013
  end-page: 541
  ident: CR183
  article-title: Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor
  publication-title: Clin Sci (Lond)
  doi: 10.1042/CS20120448
– volume: 763
  start-page: 3
  year: 2015
  end-page: 14
  ident: CR188
  article-title: The renin-angiotensin system and its involvement in vascular disease
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2015.03.090
– volume: 12
  start-page: 169
  year: 2013
  ident: CR208
  article-title: Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors
  publication-title: Cardiovasc Diabetol
  doi: 10.1186/1475-2840-12-169
– volume: 49
  start-page: 2507
  year: 2006
  end-page: 2513
  ident: CR197
  article-title: Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus
  publication-title: Diabetologia
  doi: 10.1007/s00125-006-0385-2
– volume: 24
  start-page: 796
  year: 2013
  end-page: 802
  ident: CR165
  article-title: Curcumin decreases renal triglyceride accumulation through AMPK-SREBP signaling pathway in streptozotocin-induced type 1 diabetic rats
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2012.04.013
– ident: CR213
– volume: 590
  start-page: 276
  year: 2008
  end-page: 280
  ident: CR46
  article-title: The angiotensin-(1–7) receptor agonist AVE0991 is cardioprotective in diabetic rats
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2008.05.024
– volume: 100
  start-page: 312
  year: 2015
  end-page: 322
  ident: CR78
  article-title: Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle
  publication-title: Exp Physiol
  doi: 10.1113/expphysiol.2014.084095
– volume: 128
  start-page: 227
  year: 2015
  end-page: 234
  ident: CR190
  article-title: Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison
  publication-title: Clin Sci (Lond)
  doi: 10.1042/CS20130515
– volume: 295
  start-page: F698
  year: 2008
  end-page: 706
  ident: CR9
  article-title: Oxidative stress-induced renal angiotensin AT1 receptor upregulation causes increased stimulation of sodium transporters and hypertension
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.90308.2008
– ident: CR33
– volume: 34
  start-page: 165
  year: 2010
  end-page: 171
  ident: CR37
  article-title: Adiponectin directly improves endothelial dysfunction in obese rats through the AMPK-eNOS Pathway
  publication-title: Int J Obes
  doi: 10.1038/ijo.2009.205
– ident: CR184
– volume: 116
  start-page: 1784
  year: 2006
  end-page: 1792
  ident: CR79
  article-title: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
  publication-title: J Clin Investig
  doi: 10.1172/JCI29126
– volume: 17
  start-page: 330
  year: 2012
  end-page: 341
  ident: CR217
  article-title: Link between the renin-angiotensin system and insulin resistance: Implications for cardiovascular disease
  publication-title: Vasc Med
  doi: 10.1177/1358863X12450094
– volume: 148
  start-page: 3773
  year: 2007
  end-page: 3780
  ident: CR167
  article-title: Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling
  publication-title: Endocrinology
  doi: 10.1210/en.2006-1691
– volume: 69
  start-page: 108
  year: 2014
  end-page: 115
  ident: CR215
  article-title: Atg5 deficiency-mediated mitophagy aggravates cardiac inflammation and injury in response to angiotensin II
  publication-title: Free Radical Biol Med
  doi: 10.1016/j.freeradbiomed.2014.01.002
– volume: 229
  start-page: 232
  year: 2013
  end-page: 241
  ident: CR7
  article-title: Oxidative stress and myocardial injury in the diabetic heart
  publication-title: Journal of Pathology
  doi: 10.1002/path.4113
– ident: CR44
– volume: 115
  start-page: 3587
  year: 2005
  end-page: 3593
  ident: CR114
  article-title: Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
  publication-title: J Clin Invest
  doi: 10.1172/JCI25151
– volume: 485
  start-page: 251
  year: 2012
  end-page: U142
  ident: CR128
  article-title: Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
  publication-title: Nature
  doi: 10.1038/nature10992
– volume: 355
  start-page: 1575
  year: 2000
  end-page: 1581
  ident: CR53
  article-title: Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients
  publication-title: Lancet
  doi: 10.1016/S0140-6736(00)02212-1
– volume: 292
  start-page: C82
  year: 2007
  end-page: C97
  ident: CR110
  article-title: Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00287.2006
– ident: CR139
– volume: 19
  start-page: 3033
  year: 2013
  end-page: 3042
  ident: CR90
  article-title: Angiotensin II blockade and renal protection
  publication-title: Curr Pharm Des
  doi: 10.2174/1381612811319170009
– volume: 39
  start-page: 237
  year: 2016
  end-page: 244
  ident: CR193
  article-title: Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure
  publication-title: Hypertens Res
  doi: 10.1038/hr.2015.141
– volume: 165
  start-page: 459
  year: 2003
  end-page: 462
  ident: CR73
  article-title: The effect of losartan versus atenolol on cardiovascular morbidity and mortality in patients with diabetes mellitus in the LIFE-study
  publication-title: Ugeskr Laeger
– volume: 61
  start-page: 21
  year: 2018
  end-page: 28
  ident: CR76
  article-title: Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease
  publication-title: Diabetologia
  doi: 10.1007/s00125-017-4390-4
– volume: 85
  start-page: 473
  year: 2010
  end-page: 483
  ident: CR107
  article-title: NF-kappaB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvp305
– volume: 52
  start-page: 1019
  year: 2012
  end-page: 1026
  ident: CR16
  article-title: Genetic loss of insulin receptors worsens cardiac efficiency in diabetes
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2012.02.001
– volume: 6
  start-page: 943
  year: 2015
  end-page: 960
  ident: CR191
  article-title: Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy
  publication-title: World J Diabetes
  doi: 10.4239/wjd.v6.i7.943
– volume: 76
  start-page: 280
  year: 2007
  end-page: 291
  ident: CR25
  article-title: Functional, structural and molecular aspects of diastolic heart failure in the diabetic (mRen-2)27 rat
  publication-title: Cardiovasc Res
  doi: 10.1016/j.cardiores.2007.06.022
– volume: 358
  start-page: 1941
  year: 2008
  end-page: 1950
  ident: CR47
  article-title: Nonsurgical management of obesity in adults
  publication-title: N Engl J Med
  doi: 10.1056/Nejmcp0801652
– volume: 112
  start-page: 1104-+
  year: 2013
  ident: CR93
  article-title: Discovery and characterization of alamandine a novel component of the renin-angiotensin system
  publication-title: Circ Res
  doi: 10.1161/Circresaha.113.301077
– volume: 309
  start-page: C593
  year: 2015
  end-page: 599
  ident: CR105
  article-title: O-GlcNAcase overexpression reverses coronary endothelial cell dysfunction in type 1 diabetic mice
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00069.2015
– volume: 119
  start-page: 1272
  year: 2009
  end-page: U1111
  ident: CR15
  article-title: Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart
  publication-title: Circulation
  doi: 10.1161/Circulationaha.108.792101
– ident: CR70
– volume: 55
  start-page: 1544
  year: 2012
  end-page: 1553
  ident: CR72
  article-title: Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db/db mouse model of type 2 diabetes
  publication-title: Diabetologia
  doi: 10.1007/s00125-012-2495-3
– volume: 302
  start-page: C597
  year: 2012
  end-page: C604
  ident: CR104
  article-title: Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00331.2011
– volume: 52
  start-page: 655
  year: 2008
  end-page: 666
  ident: CR216
  article-title: Metallothionein suppresses angiotensin II-induced nicotinamide adenine dinucleotide phosphate oxidase activation, nitrosative stress, apoptosis, and pathological remodeling in the diabetic heart
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2008.05.019
– volume: 160
  start-page: 1273
  year: 2010
  end-page: 1292
  ident: CR103
  article-title: Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status
  publication-title: Br J Pharmacol
  doi: 10.1111/j.1476-5381.2010.00750.x
– volume: 288
  start-page: 18077
  year: 2013
  end-page: 18092
  ident: CR201
  article-title: Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.474650
– volume: 59
  start-page: 76
  year: 2012
  end-page: 84
  ident: CR51
  article-title: Caloric restriction ameliorates angiotensin II-induced mitochondrial remodeling and cardiac hypertrophy
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.179457
– volume: 42
  start-page: 328
  year: 2003
  end-page: 335
  ident: CR39
  article-title: Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus
  publication-title: J Am Coll Cardiol
  doi: 10.1016/S0735-1097(03)00625-9
– volume: 107
  start-page: 372
  year: 2016
  end-page: 380
  ident: CR132
  article-title: Long-term administration of angiotensin (1–7) prevents heart and lung dysfunction in a mouse model of type 2 diabetes (db/db) by reducing oxidative stress, inflammation and pathological remodeling
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2016.02.026
– volume: 63
  start-page: 1138
  year: 2014
  end-page: 1147
  ident: CR153
  article-title: Angiotensin-(1–7)
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.113.01274
– volume: 125
  start-page: 117
  year: 2018
  end-page: 128
  ident: CR23
  article-title: Mst1 knockout enhances cardiomyocyte autophagic flux to alleviate angiotensin II-induced cardiac injury independent of angiotensin II receptors
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2018.08.028
– volume: 96
  start-page: 4239
  year: 1997
  end-page: 4245
  ident: CR218
  article-title: Effect of the ACE inhibitor lisinopril on mortality in diabetic patients with acute myocardial infarction: data from the GISSI-3 study
  publication-title: Circulation
  doi: 10.1161/01.cir.96.12.4239
– volume: 79
  start-page: 121
  year: 2006
  end-page: 129
  ident: CR52
  article-title: Cardiovascular oxidative stress is reduced by an ACE inhibitor in a rat model of streptozotocin-induced diabetes
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2005.12.036
– volume: 49
  start-page: 185
  year: 2007
  end-page: 192
  ident: CR152
  article-title: Angiotensin-(1–7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways
  publication-title: Hypertension
  doi: 10.1161/01.Hyp.0000251865.35728.2f
– volume: 106
  start-page: 246
  year: 2002
  end-page: 253
  ident: CR19
  article-title: Prevention of accelerated atherosclerosis by angiotensin-converting enzyme inhibition in diabetic apolipoprotein E-deficient mice
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000021122.63813.32
– volume: 80
  start-page: 1
  year: 2018
  end-page: 26
  ident: CR158
  article-title: The role of autophagy in the heart
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev-physiol-021317-121427
– volume: 88
  start-page: 233
  year: 2010
  end-page: 240
  ident: CR86
  article-title: Oxidative stress: a key contributor to diabetic cardiomyopathy
  publication-title: Can J Physiol Pharmacol
  doi: 10.1139/Y10-016
– volume: 114
  start-page: 597
  year: 2006
  end-page: 605
  ident: CR62
  article-title: Advanced glycation end products - sparking the development of diabetic vascular injury
  publication-title: Circulation
  doi: 10.1161/Circulationaha.106.621854
– volume: 99
  start-page: 129
  year: 2013
  end-page: 136
  ident: CR179
  article-title: Angiotensin (1–7) counteracts the negative effect of angiotensin II on insulin signalling in HUVECs
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvt065
– volume: 56
  start-page: 641
  year: 2007
  end-page: 646
  ident: CR196
  article-title: Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of angiotensin type 1 receptor antagonism
  publication-title: Diabetes
  doi: 10.2337/db06-1163
– volume: 152
  start-page: 1042
  year: 2007
  end-page: 1048
  ident: CR29
  article-title: Angiotensin AT1 receptor antagonists exert antiinflammatory effects in spontaneously hypertensive rats
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0707454
– ident: CR26
– volume: 13
  start-page: 619
  year: 2007
  end-page: 624
  ident: CR122
  article-title: The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
  publication-title: Nat Med
  doi: 10.1038/nm1574
– volume: 7
  start-page: 154
  year: 2011
  end-page: 167
  ident: CR172
  article-title: Olmesartan, an AT1 antagonist, attenuates oxidative stress, endoplasmic reticulum stress and cardiac inflammatory mediators in rats with heart failure induced by experimental autoimmune myocarditis
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.7.154
– volume: 59
  start-page: 1195
  year: 2012
  end-page: U1303
  ident: CR134
  article-title: Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1–7 in experimental heart failure in angiotensin-converting enzyme 2-null mice
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.112.191650
– volume: 110
  start-page: 3221
  year: 2004
  end-page: 3228
  ident: CR174
  article-title: Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000147233.10318.23
– volume: 36
  start-page: 208
  year: 2013
  end-page: 222
  ident: CR94
  article-title: Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes
  publication-title: Arch Pharmacal Res
  doi: 10.1007/s12272-013-0023-8
– volume: 98
  start-page: 354
  year: 2015
  end-page: 360
  ident: CR71
  article-title: HPTLC with fluorescence densitometry for simultaneous determination of some angiotensin II receptor blockers in tablets and plasma
  publication-title: J AOAC Int
  doi: 10.5740/jaoacint.14-179
– volume: 36
  start-page: 360
  year: 2000
  end-page: 363
  ident: CR17
  article-title: CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension
  publication-title: Hypertension
  doi: 10.1161/01.HYP.36.3.360
– volume: 97
  start-page: E642
  year: 2012
  end-page: E647
  ident: CR136
  article-title: Adiponectin dysregulation and insulin resistance in type 1 diabetes
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2011-2542
– volume: 7
  start-page: 1077
  year: 2011
  end-page: 1092
  ident: CR170
  article-title: Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1–7/mas receptor axis
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.7.1077
– volume: 34
  start-page: 1147
  year: 2011
  end-page: 1160
  ident: CR177
  article-title: The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain
  publication-title: Hypertens Res
  doi: 10.1038/hr.2011.105
– volume: 22
  start-page: 2193
  year: 2014
  end-page: 2200
  ident: CR89
  article-title: Progression and reversal of coronary and mesenteric vascular dysfunction associated with obesity
  publication-title: Obesity
  doi: 10.1002/oby.20837
– volume: 62
  start-page: 223
  year: 2013
  end-page: 233
  ident: CR178
  article-title: Loss of ACE2 exaggerates high-calorie diet induced insulin resistance by reduction of GLUT4 in mice
  publication-title: Diabetes
  doi: 10.2337/db12-0177
– volume: 52
  start-page: 11
  year: 2000
  end-page: 34
  ident: CR87
  article-title: Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases
  publication-title: Pharmacol Rev
– ident: CR48
– volume: 107
  start-page: 539
  year: 2004
  end-page: 557
  ident: CR69
  article-title: Diabetic cardiomyopathy: mechanisms, diagnosis and treatment
  publication-title: Clin Sci
  doi: 10.1042/CS20040057
– volume: 359
  start-page: 1004
  year: 2002
  end-page: 1010
  ident: CR98
  article-title: Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
  publication-title: Lancet
  doi: 10.1016/S0140-6736(02)08090-X
– volume: 4
  start-page: 68
  year: 2013
  ident: CR38
  article-title: Diabetes alters activation and repression of pro- and anti-inflammatory signaling pathways in the vasculature
  publication-title: Front Endocrinol (Lausanne)
  doi: 10.3389/fendo.2013.00068
– volume: 133
  start-page: e38
  year: 2016
  end-page: 360
  ident: CR115
  article-title: Heart Disease And Stroke Statistics-2016 update: a report from the American Heart Association
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000350
– volume: 33
  start-page: 1058
  year: 2014
  end-page: 1074
  ident: CR21
  article-title: Autophagy protects against senescence and apoptosis via the RAS-mitochondria in high-glucose-induced endothelial cells
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000358676
– volume: 34
  start-page: 5813
  year: 2013
  end-page: 5820
  ident: CR212
  article-title: Tissue-engineered cardiac patch for advanced functional maturation of human ESC-derived cardiomyocytes
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.04.026
– volume: 56
  start-page: 118
  year: 2007
  end-page: 126
  ident: CR127
  article-title: Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice
  publication-title: Diabetes
  doi: 10.2337/db06-0288
– volume: 7
  start-page: 1254
  year: 2011
  end-page: 1255
  ident: CR199
  article-title: AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy
  publication-title: Autophagy
  doi: 10.4161/auto.7.10.16740
– volume: 123
  start-page: 5319
  year: 2013
  end-page: 5333
  ident: CR147
  article-title: Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
  publication-title: J Clin Invest
  doi: 10.1172/JCI71171
– volume: 164
  start-page: 1737
  year: 2004
  end-page: 1748
  ident: CR96
  article-title: Diabetes mellitus, the renin-angiotensin-aldosterone system, and the heart
  publication-title: Arch Intern Med
  doi: 10.1001/archinte.164.16.1737.164/16/1737[pii]
– volume: 23
  start-page: S9
  year: 2005
  end-page: S17
  ident: CR45
  article-title: The cardiovascular continuum and renin-angiotensin-aldosterone system blockade
  publication-title: J Hypertens
  doi: 10.1097/01.hjh.0000165623.72310.dd
– volume: 68
  start-page: 185
  year: 2016
  end-page: 194
  ident: CR181
  article-title: G-protein-coupled receptor MrgD is a receptor for angiotensin-(1–7) involving adenylyl cyclase, cAMP, and phosphokinase A
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.116.07572
– volume: 11
  start-page: 413
  year: 2014
  end-page: 426
  ident: CR77
  article-title: Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
  publication-title: Nat Rev Cardiol
  doi: 10.1038/nrcardio.2014.59
– volume: 351
  start-page: 208
  year: 2012
  end-page: 219
  ident: CR171
  article-title: Olmesartan attenuates the development of heart failure after experimental autoimmune myocarditis in rats through the modulation of ANG 1–7 mas receptor
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2011.12.010
– volume: 42
  start-page: 206
  year: 2003
  end-page: 212
  ident: CR142
  article-title: AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NADPH oxidase
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000082814.62655.85
– volume: 50
  start-page: 1414
  year: 2001
  end-page: 1424
  ident: CR80
  article-title: IGF-1 overexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress
  publication-title: Diabetes
  doi: 10.2337/diabetes.50.6.1414
– ident: CR101
– volume: 292
  start-page: H736
  year: 2007
  end-page: 742
  ident: CR63
  article-title: Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1–7)
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00937.2006
– volume: 31
  start-page: 145
  year: 2017
  end-page: 156
  ident: CR58
  article-title: Inhibition of the renin-angiotensin system post myocardial infarction prevents inflammation-associated acute cardiac rupture
  publication-title: Cardiovasc Drugs Ther
  doi: 10.1007/s10557-017-6717-2[pii]
– volume: 1852
  start-page: 232
  year: 2015
  end-page: 242
  ident: CR189
  article-title: Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2014.06.030
– volume: 6
  year: 2011
  ident: CR210
  article-title: Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0016239
– volume: 14
  start-page: 10497
  year: 2013
  end-page: 10538
  ident: CR156
  article-title: Obesity-associated oxidative stress: strategies finalized to improve redox state
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms140510497
– volume: 83
  start-page: 653
  year: 2012
  end-page: 660
  ident: CR92
  article-title: Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Toni) rats
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2011.11.018
– volume: 45
  start-page: 438
  year: 2005
  end-page: 444
  ident: CR88
  article-title: Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000157169.27818.ae
– volume: 2011
  year: 2011
  ident: CR168
  article-title: Role of the renin-angiotensin system and aldosterone on cardiometabolic syndrome
  publication-title: Int J Hypertens
  doi: 10.4061/2011/685238
– volume: 8
  start-page: 312
  year: 2008
  end-page: 318
  ident: CR204
  article-title: Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2007.06.012
– volume: 103
  start-page: 137
  year: 2014
  end-page: 149
  ident: CR64
  article-title: Global estimates of diabetes prevalence for 2013 and projections for 2035
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/j.diabres.2013.11.002
– volume: 5
  start-page: 1215
  year: 2009
  end-page: 1216
  ident: CR141
  article-title: Cardiomyocyte autophagy is regulated by angiotensin II type 1 and type 2 receptors
  publication-title: Autophagy
  doi: 10.4161/auto.5.8.10153
– volume: 11
  start-page: 1146
  year: 2015
  end-page: 1160
  ident: CR82
  article-title: Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes
  publication-title: Autophagy
  doi: 10.1080/15548627.2015.1051295
– volume: 18
  start-page: 1
  year: 2014
  end-page: 14
  ident: CR163
  article-title: Advanced glycation end products and diabetic complications
  publication-title: Korean J Physiol Pharmacol
  doi: 10.4196/kjpp.2014.18.1.1
– volume: 323
  start-page: 359
  year: 2014
  end-page: 365
  ident: CR34
  article-title: Angiotensin (1–7) re-establishes heart cell communication previously impaired by cell swelling: Implications for myocardial ischemia
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2014.03.006
– ident: CR18
– volume: 102
  start-page: 488
  year: 2008
  end-page: 496
  ident: CR43
  article-title: Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.107.162800
– volume: 165
  start-page: 200
  year: 2010
  end-page: 205
  ident: CR36
  article-title: Further studies on the effects of intracrine and extracellular angiotensin II on the regulation of heart cell volume. On the influence of aldosterone and spironolactone
  publication-title: Regul Pept
  doi: 10.1016/j.regpep.2010.07.165
– volume: 5
  start-page: 3757
  year: 2013
  end-page: 3778
  ident: CR194
  article-title: Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance
  publication-title: Nutrients
  doi: 10.3390/nu5093757
– volume: 318
  start-page: 1049
  year: 2012
  end-page: 1056
  ident: CR28
  article-title: Recent advances involving the renin-angiotensin system
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2012.02.023
– volume: 11
  start-page: 56
  year: 2011
  end-page: 63
  ident: CR83
  article-title: Update on the prevention of type 2 diabetes
  publication-title: Curr DiabRep
  doi: 10.1007/s11892-010-0163-x
– volume: 133
  start-page: 1249
  year: 2016
  end-page: 1263
  ident: CR161
  article-title: Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure
  publication-title: Circulation
  doi: 10.1161/Circulationaha.115.020502
– volume: 52
  start-page: 415
  year: 2000
  end-page: 472
  ident: CR32
  article-title: International union of pharmacology. XXIII. The angiotensin II receptors
  publication-title: Pharmacol Rev
– volume: 82
  start-page: S42
  year: 2008
  end-page: S45
  ident: CR65
  article-title: Role of reactive oxygen species in the pathogenesis of diabetic nephropathy
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/j.diabres.2008.09.017
– volume: 87
  start-page: 1123
  year: 2000
  end-page: 1132
  ident: CR54
  article-title: Myocardial cell death in human diabetes
  publication-title: Circ Res
  doi: 10.1161/01.RES.87.12.1123
– volume: 20
  start-page: 164
  year: 2014
  end-page: 182
  ident: CR112
  article-title: Reactive oxygen species, vascular noxs, and hypertension: focus on translational and clinical research
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5302
– volume: 56
  start-page: 2115
  year: 2010
  end-page: 2125
  ident: CR145
  article-title: Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2010.07.033
– volume: 95
  start-page: 1247
  year: 1997
  end-page: 1252
  ident: CR207
  article-title: Tumor necrosis factor-alpha provokes a hypertrophic growth response in adult cardiac myocytes
  publication-title: Circulation
  doi: 10.1161/01.CIR.95.5.1247
– volume: 35
  start-page: 1183
  year: 2000
  end-page: 1188
  ident: CR35
  article-title: Angiotensin II and the heart - on the intracrine renin-angiotensin system
  publication-title: Hypertension
  doi: 10.1161/01.HYP.35.6.1183
– volume: 298
  start-page: F683
  year: 2010
  end-page: F691
  ident: CR120
  article-title: Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis
  publication-title: Am J Physiol-Renal Physiol
  doi: 10.1152/ajprenal.00503.2009
– volume: 48
  start-page: 95
  year: 2006
  end-page: 102
  ident: CR109
  article-title: Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction
  publication-title: J Cardiovasc Pharmacol
  doi: 10.1097/01.fjc.0000245405.41317.60
– volume: 2
  start-page: 73
  year: 2014
  ident: CR126
  article-title: Exercise and NO production: relevance and implications in the cardiopulmonary system
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2014.00073
– volume: 288
  start-page: 15520
  year: 2013
  end-page: 15531
  ident: CR182
  article-title: Control of adipogenesis by the autocrine interplays between angiotensin 1–7/Mas receptor and angiotensin II/AT(1) receptor signaling pathways
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.459792
– volume: 66
  start-page: 265
  year: 2005
  end-page: 275
  ident: CR91
  article-title: Inflammatory markers and cardiovascular health in older adults
  publication-title: Cardiovasc Res
  doi: 10.1016/j.cardiores.2004.12.026
– volume: 119
  start-page: 524
  year: 2009
  end-page: 530
  ident: CR11
  article-title: Disruption of the Ang II type 1 receptor promotes longevity in mice
  publication-title: J Clin Investig
  doi: 10.1172/JCI36703
– volume: 216
  start-page: R1
  year: 2013
  end-page: R17
  ident: CR154
  article-title: Angiotensin-converting enzyme 2, angiotensin-(1–7) and Mas: new players of the renin-angiotensin system
  publication-title: J Endocrinol
  doi: 10.1530/Joe-12-0341
– volume: 81
  start-page: 455
  year: 2003
  end-page: 470
  ident: CR42
  article-title: Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-003-0450-y
– volume: 62
  start-page: E147
  year: 2013
  end-page: E239
  ident: CR202
  article-title: 2013 ACCF/AHA Guideline for the Management of Heart Failure A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2013.05.019
– volume: 75
  start-page: 29
  year: 2007
  end-page: 39
  ident: CR130
  article-title: Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice
  publication-title: Cardiovasc Res
  doi: 10.1016/j.cardiores.2007.04.007
– volume: 13
  start-page: 9
  year: 2007
  end-page: 20
  ident: CR8
  article-title: The renin-angiotensin aldosterone system: pathophysiological role and pharmacologic inhibition
  publication-title: J Manag Care Pharm
  doi: 10.18553/jmcp.2007.13.s8-b
– volume: 57
  start-page: 452
  year: 2011
  end-page: 459
  ident: CR10
  article-title: Oxidative stress causes renal angiotensin II type 1 receptor upregulation, Na+/H+ exchanger 3 overstimulation, and hypertension
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.110.162339
– volume: 16
  start-page: 130
  year: 2016
  end-page: 137
  ident: CR59
  article-title: Resveratrol ameliorates diabetes-induced cardiac dysfunction through AT1R-ERK/p38 MAPK signaling pathway
  publication-title: Cardiovasc Toxicol
  doi: 10.1007/s12012-015-9321-3
– volume: 53
  start-page: 1032
  year: 2009
  end-page: 1040
  ident: CR140
  article-title: Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.108.128488
– volume: 14
  start-page: 21525
  year: 2013
  end-page: 21550
  ident: CR138
  article-title: Oxidative stress in diabetes: implications for vascular and other complications
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms141121525
– volume: 123
  start-page: 803
  year: 2018
  end-page: 824
  ident: CR1
  article-title: Autophagy in cardiovascular aging
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.118.312208
– volume: 52
  start-page: 542
  year: 2008
  end-page: 548
  ident: CR40
  article-title: Molecular mechanisms involved in the angiotensin-(1–7)/Mas signaling pathway in cardiomyocytes
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.108.114280
– ident: CR41
– volume: 16
  start-page: S3
  issue: Suppl 1
  year: 2005
  end-page: S10
  ident: CR186
  article-title: Epidemiology of the diabetic heart
  publication-title: Coron Artery Dis
  doi: 10.1097/00019501-200511001-00002
– volume: 106
  start-page: 8665
  year: 2009
  end-page: 8670
  ident: CR148
  article-title: Antioxidants prevent health-promoting effects of physical exercise in humans
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0903485106
– ident: CR205
– volume: 68
  start-page: 85
  year: 1991
  end-page: 89
  ident: CR56
  article-title: Echocardiographic evidence for the existence of a distinct diabetic cardiomyopathy (the Framingham Heart Study)
  publication-title: Am J Cardiol
  doi: 10.1016/0002-9149(91)90716-X
– volume: 35
  start-page: 4
  year: 2012
  end-page: 16
  ident: CR81
  article-title: Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications
  publication-title: Hypertens Res
  doi: 10.1038/hr.2011.173
– volume: 5
  start-page: 159
  year: 2011
  end-page: 167
  ident: CR162
  article-title: Beneficial effects of angiotensin (1–7) in diabetic rats with cardiomyopathy
  publication-title: Ther Adv Cardiovasc Dis
  doi: 10.1177/1753944711409281
– volume: 25
  start-page: 543
  year: 2004
  end-page: 567
  ident: CR49
  article-title: Diabetic cardiomyopathy: evidence, mechanisms, and therapeutic implications
  publication-title: Endocr Rev
  doi: 10.1210/er.2003-0012.25/4/543[pii]
– volume: 440
  start-page: 354
  year: 2013
  end-page: 358
  ident: CR159
  article-title: High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2013.09.086
– volume: 5
  start-page: 444
  year: 2014
  end-page: 470
  ident: CR108
  article-title: Type 2 diabetes and cardiovascular disease: have all risk factors the same strength?
  publication-title: World J Diabetes
  doi: 10.4239/wjd.v5.i4.444
– volume: 6
  start-page: 42
  year: 2008
  end-page: 50
  ident: CR206
  article-title: Renin-angiotensin system - considerations for hypertension and kidney
  publication-title: Electrolyte Blood Press
  doi: 10.5049/EBP.2008.6.1.42
– volume: 97
  start-page: 3A
  year: 2006
  end-page: 11A
  ident: CR67
  article-title: The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2005.11.010
– volume: 23
  start-page: 538
  year: 2013
  end-page: 542
  ident: CR117
  article-title: Frequency of diabetic cardiomyopathy among type-2 diabetics presenting as heart failure
  publication-title: Jcpsp-J Coll Physicians Surg Pakistan
– volume: 28
  start-page: 851
  year: 1996
  end-page: 858
  ident: CR175
  article-title: Angiotensin converting enzyme and myofibroblasts during tissue repair in the rat heart
  publication-title: J Mol Cell Cardiol
  doi: 10.1006/jmcc.1996.0080
– volume: 2
  start-page: 446
  year: 2009
  end-page: 455
  ident: CR84
  article-title: Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
  publication-title: Circulation-Heart Failure
  doi: 10.1161/Circheartfailure.108.840124
– volume: 22
  start-page: 732
  year: 2009
  end-page: 738
  ident: CR3
  article-title: Assessment of atrial electromechanical delay, diastolic functions, and left atrial mechanical functions in patients with type 1 diabetes mellitus
  publication-title: J Am Soc Echocardiogr
  doi: 10.1016/j.echo.2009.03.028
– volume: 8
  year: 2013
  ident: CR192
  article-title: Decreased autophagy in rat heart induced by anti-beta1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0081296
– volume: 49
  start-page: 6
  year: 2007
  end-page: 12
  ident: CR198
  article-title: Angiotensin II type 1 receptor blockade improves hyperglycemia-induced endothelial dysfunction and reduces proinflammatory cytokine release from leukocytes
  publication-title: J Cardiovasc Pharmacol
  doi: 10.1097/Fjc.0b013e31802b31a7
– volume: 291
  start-page: H336
  year: 2006
  end-page: 343
  ident: CR214
  article-title: ANG II-induced cardiac molecular and cellular events: role of aldosterone
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.01307.2005
– volume: 13
  start-page: 1751
  year: 2009
  end-page: 1764
  ident: CR102
  article-title: Advanced glycation endproduct (AGE) accumulation and AGE receptor (RAGE) up-regulation contribute to the onset of diabetic cardiomyopathy
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2008.00547.x
– volume: 94
  start-page: 1211
  year: 2004
  end-page: 1218
  ident: CR6
  article-title: Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser(312) and Ser(616) in human umbilical vein endothelial cells
  publication-title: Circ Res
  doi: 10.1161/01.Res.0000126501.34994.96
– volume: 65
  start-page: 85
  year: 2016
  end-page: 95
  ident: CR135
  article-title: ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity
  publication-title: Diabetes
  doi: 10.2337/db15-0399
– volume: 227
  start-page: 226
  year: 2013
  end-page: 227
  ident: CR50
  article-title: The enigma of adiponectin
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2012.11.018
– volume: 12
  start-page: 144
  year: 2016
  end-page: 153
  ident: CR75
  article-title: Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/nrendo.2015.216
– volume: 4
  year: 2015
  ident: CR123
  article-title: Pharmacologic approaches against advanced glycation end products (AGEs) in diabetic cardiovascular disease
  publication-title: Res Cardiovasc Med
  doi: 10.5812/cardiovascmed.4(2)2015.26949
– volume: 292
  start-page: H666
  year: 2007
  end-page: 672
  ident: CR12
  article-title: Angiotensin-(1–7) prevents diabetes-induced cardiovascular dysfunction
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00372.2006
– volume: 59
  start-page: 1778
  year: 2016
  end-page: 1790
  ident: CR24
  article-title: The angiotensin II type 2 receptor agonist Compound 21 is protective in experimental diabetes-associated atherosclerosis
  publication-title: Diabetologia
  doi: 10.1007/s00125-016-3977-5
– volume: 11
  start-page: 31
  year: 2010
  end-page: 39
  ident: CR14
  article-title: Diabetic cardiomyopathy, causes and effects
  publication-title: Rev Endocr Metab Disord
  doi: 10.1007/s11154-010-9131-7
– volume: 652
  start-page: 126
  year: 2011
  end-page: 135
  ident: CR173
  article-title: Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2010.10.081
– volume: 18
  start-page: 149
  year: 2013
  end-page: 166
  ident: CR111
  article-title: Diabetic cardiomyopathy: pathophysiology and clinical features
  publication-title: Heart Fail Rev
  doi: 10.1007/s10741-012-9313-3
– ident: CR200
– volume: 23
  start-page: 69
  year: 2015
  end-page: 72
  ident: CR22
  article-title: Adiponectin inhibits oxidative stress and modulates TGF-b1 and COL-1 expression via the AMPK pathway in HSC-T6 cells
  publication-title: Zhonghua Gan Zang Bing Za Zhi
– volume: 293
  start-page: H1154
  year: 2007
  end-page: 1163
  ident: CR60
  article-title: Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.01395.2006
– volume: 296
  start-page: E262
  year: 2009
  end-page: 271
  ident: CR61
  article-title: Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.90678.2008
– volume: 23
  start-page: 3806
  year: 2008
  end-page: 3813
  ident: CR155
  article-title: Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy
  publication-title: Nephrol Dial Transplant
  doi: 10.1093/ndt/gfn357
– volume: 20
  start-page: 304
  year: 2014
  end-page: 309
  ident: CR31
  article-title: The prevalence of diabetic cardiomyopathy: a population-based study in Olmsted County, Minnesota
  publication-title: J Cardiac Fail
  doi: 10.1016/j.cardfail.2014.02.007
– volume: 93
  start-page: 1571
  year: 2007
  end-page: 1576
  ident: CR66
  article-title: Abnormal left ventricular longitudinal functional reserve in patients with diabetes mellitus: implication for detecting subclinical myocardial dysfunction using exercise tissue Doppler echocardiography
  publication-title: Heart
  doi: 10.1136/hrt.2006.101667
– volume: 93
  start-page: 2372
  year: 1994
  end-page: 2378
  ident: CR27
  article-title: Characterization of angiotensin-ii receptors in cultured adult-rat cardiac fibroblasts - coupling to signaling systems and gene-expression
  publication-title: J Clin Investig
  doi: 10.1172/Jci117243
– volume: 169
  start-page: 798
  year: 2009
  end-page: 807
  ident: CR116
  article-title: Lifestyle risk factors and new-onset diabetes mellitus in older adults the cardiovascular health study
  publication-title: Arch Intern Med
  doi: 10.1001/archinternmed.2009.21
– volume: 59
  start-page: 71
  year: 2010
  end-page: 79
  ident: CR169
  article-title: Sympathetic neural adaptation to hypocaloric diet with or without exercise training in obese metabolic syndrome subjects
  publication-title: Diabetes
  doi: 10.2337/db09-0934
– volume: 161
  start-page: 1
  year: 2010
  end-page: 7
  ident: CR118
  article-title: Angiotensin-(1–7) stimulates the phosphorylation of Akt in rat extracardiac tissues in vivo via receptor Mas
  publication-title: Regul Pept
  doi: 10.1016/j.regpep.2010.02.001
– volume: 56
  start-page: 97
  year: 2019
  end-page: 104
  ident: CR20
  article-title: Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats
  publication-title: Acta Diabetol
  doi: 10.1007/s00592-018-1220-1
– volume: 54
  start-page: 1891
  year: 2009
  end-page: 1898
  ident: CR5
  article-title: Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2009.07.031
– ident: CR146
– volume: 72
  start-page: 219
  year: 2010
  end-page: 246
  ident: CR129
  article-title: Macrophages, inflammation, and insulin resistance
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev-physiol-021909-135846
– volume: 94
  start-page: 1630
  year: 2004
  end-page: 1637
  ident: CR124
  article-title: Cardiac angiotensin II participates in coronary microvessel inflammation of unstable angina and strengthens the immunomediated component
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000130944.49657.b8
– volume: 47
  start-page: 604
  year: 2012
  end-page: 614
  ident: CR166
  article-title: Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC-MAPK signaling pathway
  publication-title: Eur J Pharm Sci
  doi: 10.1016/j.ejps.2012.04.018
– volume: 48
  start-page: 68
  year: 2011
  end-page: 71
  ident: CR185
  article-title: Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus
  publication-title: J Clin Biochem Nutr
  doi: 10.3164/jcbn.11-012FR
– volume: 53
  start-page: 294
  year: 2012
  end-page: 303
  ident: CR95
  article-title: Effects of N-acetylcysteine on nicotinamide dinucleotide phosphate oxidase activation and antioxidant status in heart, lung, liver and kidney in streptozotocin-induced diabetic rats
  publication-title: Yonsei Med J
  doi: 10.3349/ymj.2012.53.2.294
– volume: 406
  start-page: 906
  year: 2000
  end-page: 910
  ident: CR125
  article-title: Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)
  publication-title: Nature
  doi: 10.1038/35022604
– volume: 20
  start-page: 48
  year: 2016
  end-page: 57
  ident: CR97
  article-title: Mas receptor mediates cardioprotection of angiotensin-(1–7) against angiotensin II-induced cardiomyocyte autophagy and cardiac remodelling through inhibition of oxidative stress
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.12687
– volume: 12
  start-page: 579
  year: 2016
  end-page: 587
  ident: CR150
  article-title: Autophagic vacuoles in cardiomyocytes of dilated cardiomyopathy with initially decompensated heart failure predict improved prognosis
  publication-title: Autophagy
  doi: 10.1080/15548627.2016.1145326
– volume: 133
  start-page: 2459
  year: 2016
  end-page: 2502
  ident: CR100
  article-title: Clinical update: cardiovascular disease in diabetes mellitus: atherosclerotic cardiovascular disease and heart failure in type 2 diabetes mellitus - mechanisms, management, and clinical considerations
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.022194
– volume: 35
  start-page: 186
  year: 2012
  end-page: 193
  ident: CR119
  article-title: Cardiac remodeling and diastolic dysfunction in DahlS.Z-Lepr(fa)/Lepr(fa) rats: a new animal model of metabolic syndrome
  publication-title: Hypertens Res
  doi: 10.1038/hr.2011.157
– volume: 98
  start-page: 33
  year: 2002
  end-page: 39
  ident: CR157
  article-title: Left ventricular diastolic dysfunction as an early manifestation of diabetic cardiomyopathy
  publication-title: Cardiology
  doi: 10.1159/000064682
– volume: 12
  start-page: 454
  year: 2010
  end-page: 461
  ident: CR149
  article-title: Effect of diabetes and hypertension on left ventricular diastolic function in a high-risk population without evidence of heart disease
  publication-title: Eur J Heart Fail
  doi: 10.1093/eurjhf/hfq022
– ident: 2651_CR44
  doi: 10.1161/Atvbaha.116.307518
– volume: 35
  start-page: 411
  year: 2004
  ident: 2651_CR4
  publication-title: Arch Med Res
  doi: 10.1016/j.arcmed.2004.05.003
– volume: 49
  start-page: 185
  year: 2007
  ident: 2651_CR152
  publication-title: Hypertension
  doi: 10.1161/01.Hyp.0000251865.35728.2f
– volume: 31
  start-page: 145
  year: 2017
  ident: 2651_CR58
  publication-title: Cardiovasc Drugs Ther
  doi: 10.1007/s10557-017-6717-2[pii]
– volume: 440
  start-page: 354
  year: 2013
  ident: 2651_CR159
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2013.09.086
– ident: 2651_CR184
  doi: 10.1253/circj.CJ-08-0014
– volume: 54
  start-page: 1891
  year: 2009
  ident: 2651_CR5
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2009.07.031
– volume: 5
  start-page: 3757
  year: 2013
  ident: 2651_CR194
  publication-title: Nutrients
  doi: 10.3390/nu5093757
– volume: 56
  start-page: 2115
  year: 2010
  ident: 2651_CR145
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2010.07.033
– volume: 48
  start-page: 95
  year: 2006
  ident: 2651_CR109
  publication-title: J Cardiovasc Pharmacol
  doi: 10.1097/01.fjc.0000245405.41317.60
– volume: 14
  start-page: 21525
  year: 2013
  ident: 2651_CR138
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms141121525
– volume: 17
  start-page: 330
  year: 2012
  ident: 2651_CR217
  publication-title: Vasc Med
  doi: 10.1177/1358863X12450094
– volume: 295
  start-page: F698
  year: 2008
  ident: 2651_CR9
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.90308.2008
– volume: 11
  start-page: 1146
  year: 2015
  ident: 2651_CR82
  publication-title: Autophagy
  doi: 10.1080/15548627.2015.1051295
– volume: 229
  start-page: 232
  year: 2013
  ident: 2651_CR7
  publication-title: Journal of Pathology
  doi: 10.1002/path.4113
– ident: 2651_CR18
  doi: 10.1136/bmj.b688
– volume: 227
  start-page: 226
  year: 2013
  ident: 2651_CR50
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2012.11.018
– volume: 35
  start-page: 186
  year: 2012
  ident: 2651_CR119
  publication-title: Hypertens Res
  doi: 10.1038/hr.2011.157
– volume: 4
  year: 2015
  ident: 2651_CR123
  publication-title: Res Cardiovasc Med
  doi: 10.5812/cardiovascmed.4(2)2015.26949
– volume: 164
  start-page: 1737
  year: 2004
  ident: 2651_CR96
  publication-title: Arch Intern Med
  doi: 10.1001/archinte.164.16.1737.164/16/1737[pii]
– volume: 18
  start-page: 1
  year: 2014
  ident: 2651_CR163
  publication-title: Korean J Physiol Pharmacol
  doi: 10.4196/kjpp.2014.18.1.1
– volume: 7
  start-page: 327
  year: 2014
  ident: 2651_CR113
  publication-title: Circulation-Heart Failure
  doi: 10.1161/Circheartfailure.113.000672
– volume: 165
  start-page: 200
  year: 2010
  ident: 2651_CR36
  publication-title: Regul Pept
  doi: 10.1016/j.regpep.2010.07.165
– volume: 78
  start-page: 300
  year: 2014
  ident: 2651_CR180
  publication-title: Circ J
  doi: 10.1253/circj.CJ-13-1187
– volume: 18
  start-page: 149
  year: 2013
  ident: 2651_CR111
  publication-title: Heart Fail Rev
  doi: 10.1007/s10741-012-9313-3
– volume: 34
  start-page: 165
  year: 2010
  ident: 2651_CR37
  publication-title: Int J Obes
  doi: 10.1038/ijo.2009.205
– volume: 590
  start-page: 276
  year: 2008
  ident: 2651_CR46
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2008.05.024
– volume: 20
  start-page: 304
  year: 2014
  ident: 2651_CR31
  publication-title: J Cardiac Fail
  doi: 10.1016/j.cardfail.2014.02.007
– volume: 65
  start-page: 85
  year: 2016
  ident: 2651_CR135
  publication-title: Diabetes
  doi: 10.2337/db15-0399
– volume: 52
  start-page: 655
  year: 2008
  ident: 2651_CR216
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2008.05.019
– volume: 16
  start-page: 25234
  year: 2015
  ident: 2651_CR85
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms161025234
– volume: 88
  start-page: 389
  year: 2008
  ident: 2651_CR2
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00017.2007
– volume: 20
  start-page: 164
  year: 2014
  ident: 2651_CR112
  publication-title: Antioxid Redox Signal
  doi: 10.1089/ars.2013.5302
– volume: 20
  start-page: 48
  year: 2016
  ident: 2651_CR97
  publication-title: J Cell Mol Med
  doi: 10.1111/jcmm.12687
– volume: 114
  start-page: 597
  year: 2006
  ident: 2651_CR62
  publication-title: Circulation
  doi: 10.1161/Circulationaha.106.621854
– volume: 13
  start-page: 1751
  year: 2009
  ident: 2651_CR102
  publication-title: J Cell Mol Med
  doi: 10.1111/j.1582-4934.2008.00547.x
– volume: 2
  start-page: 73
  year: 2014
  ident: 2651_CR126
  publication-title: Front Cell Dev Biol
  doi: 10.3389/fcell.2014.00073
– volume: 35
  start-page: 1183
  year: 2000
  ident: 2651_CR35
  publication-title: Hypertension
  doi: 10.1161/01.HYP.35.6.1183
– volume: 763
  start-page: 3
  year: 2015
  ident: 2651_CR188
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2015.03.090
– volume: 318
  start-page: 1049
  year: 2012
  ident: 2651_CR28
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2012.02.023
– volume: 25
  start-page: 543
  year: 2004
  ident: 2651_CR49
  publication-title: Endocr Rev
  doi: 10.1210/er.2003-0012.25/4/543[pii]
– volume: 293
  start-page: H1154
  year: 2007
  ident: 2651_CR60
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.01395.2006
– volume: 50
  start-page: 1093
  year: 2007
  ident: 2651_CR151
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.106.084848
– volume: 81
  start-page: 455
  year: 2003
  ident: 2651_CR42
  publication-title: J Mol Med (Berl)
  doi: 10.1007/s00109-003-0450-y
– ident: 2651_CR205
  doi: 10.1371/journal.pone.0056803
– volume: 49
  start-page: 6
  year: 2007
  ident: 2651_CR198
  publication-title: J Cardiovasc Pharmacol
  doi: 10.1097/Fjc.0b013e31802b31a7
– volume: 5
  start-page: 444
  year: 2014
  ident: 2651_CR108
  publication-title: World J Diabetes
  doi: 10.4239/wjd.v5.i4.444
– volume: 80
  start-page: 1
  year: 2018
  ident: 2651_CR158
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev-physiol-021317-121427
– volume: 310
  start-page: H153
  year: 2016
  ident: 2651_CR106
  publication-title: American Journal of Physiology-Heart and Circulatory Physiology
  doi: 10.1152/ajpheart.00206.2015
– ident: 2651_CR101
  doi: 10.1186/1475-2891-12-89
– volume: 351
  start-page: 208
  year: 2012
  ident: 2651_CR171
  publication-title: Mol Cell Endocrinol
  doi: 10.1016/j.mce.2011.12.010
– volume: 115
  start-page: 3213
  year: 2007
  ident: 2651_CR13
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.679597
– ident: 2651_CR48
  doi: 10.1371/journal.pone.0068697
– volume: 302
  start-page: H1219
  year: 2012
  ident: 2651_CR143
  publication-title: Am J Physiol-Heart Circ Physiol
  doi: 10.1152/ajpheart.00796.2011
– volume: 148
  start-page: 241
  year: 2007
  ident: 2651_CR74
  publication-title: Endocrinology
  doi: 10.1210/en.2006-0692
– volume: 292
  start-page: C82
  year: 2007
  ident: 2651_CR110
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00287.2006
– volume: 49
  start-page: 2507
  year: 2006
  ident: 2651_CR197
  publication-title: Diabetologia
  doi: 10.1007/s00125-006-0385-2
– volume: 8
  start-page: 312
  year: 2008
  ident: 2651_CR204
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2007.06.012
– volume: 69
  start-page: 108
  year: 2014
  ident: 2651_CR215
  publication-title: Free Radical Biol Med
  doi: 10.1016/j.freeradbiomed.2014.01.002
– volume: 93
  start-page: 1571
  year: 2007
  ident: 2651_CR66
  publication-title: Heart
  doi: 10.1136/hrt.2006.101667
– ident: 2651_CR146
  doi: 10.1002/14651858.Cd009671.Pub2
– volume: 17
  start-page: 613
  year: 2014
  ident: 2651_CR160
  publication-title: Iran J Basic Med Sci
– volume: 2011
  year: 2011
  ident: 2651_CR168
  publication-title: Int J Hypertens
  doi: 10.4061/2011/685238
– ident: 2651_CR57
  doi: 10.1371/journal.pone.0138609
– volume: 45
  start-page: 438
  year: 2005
  ident: 2651_CR88
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000157169.27818.ae
– volume: 48
  start-page: 68
  year: 2011
  ident: 2651_CR185
  publication-title: J Clin Biochem Nutr
  doi: 10.3164/jcbn.11-012FR
– volume: 383
  start-page: 935
  year: 2014
  ident: 2651_CR187
  publication-title: Lancet
  doi: 10.1016/S0140-6736(13)62076-0
– volume: 56
  start-page: 641
  year: 2007
  ident: 2651_CR196
  publication-title: Diabetes
  doi: 10.2337/db06-1163
– volume: 124
  start-page: 529
  year: 2013
  ident: 2651_CR183
  publication-title: Clin Sci (Lond)
  doi: 10.1042/CS20120448
– volume: 216
  start-page: R1
  year: 2013
  ident: 2651_CR154
  publication-title: J Endocrinol
  doi: 10.1530/Joe-12-0341
– volume: 68
  start-page: 185
  year: 2016
  ident: 2651_CR181
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.116.07572
– volume: 6
  start-page: 943
  year: 2015
  ident: 2651_CR191
  publication-title: World J Diabetes
  doi: 10.4239/wjd.v6.i7.943
– volume: 1852
  start-page: 232
  year: 2015
  ident: 2651_CR189
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2014.06.030
– volume: 13
  start-page: 9
  year: 2007
  ident: 2651_CR8
  publication-title: J Manag Care Pharm
  doi: 10.18553/jmcp.2007.13.s8-b
– volume: 11
  start-page: 31
  year: 2010
  ident: 2651_CR14
  publication-title: Rev Endocr Metab Disord
  doi: 10.1007/s11154-010-9131-7
– volume: 123
  start-page: 803
  year: 2018
  ident: 2651_CR1
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.118.312208
– volume: 2
  start-page: 446
  year: 2009
  ident: 2651_CR84
  publication-title: Circulation-Heart Failure
  doi: 10.1161/Circheartfailure.108.840124
– volume: 42
  start-page: 206
  year: 2003
  ident: 2651_CR142
  publication-title: Hypertension
  doi: 10.1161/01.HYP.0000082814.62655.85
– volume: 56
  start-page: 118
  year: 2007
  ident: 2651_CR127
  publication-title: Diabetes
  doi: 10.2337/db06-0288
– volume: 23
  start-page: 3806
  year: 2008
  ident: 2651_CR155
  publication-title: Nephrol Dial Transplant
  doi: 10.1093/ndt/gfn357
– volume: 34
  start-page: 1147
  year: 2011
  ident: 2651_CR177
  publication-title: Hypertens Res
  doi: 10.1038/hr.2011.105
– volume: 406
  start-page: 906
  year: 2000
  ident: 2651_CR125
  publication-title: Nature
  doi: 10.1038/35022604
– volume: 59
  start-page: 71
  year: 2010
  ident: 2651_CR169
  publication-title: Diabetes
  doi: 10.2337/db09-0934
– ident: 2651_CR200
  doi: 10.1155/2013/716219
– volume: 292
  start-page: H912
  year: 2007
  ident: 2651_CR203
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00824.2006
– volume: 50
  start-page: 1414
  year: 2001
  ident: 2651_CR80
  publication-title: Diabetes
  doi: 10.2337/diabetes.50.6.1414
– volume: 358
  start-page: 1941
  year: 2008
  ident: 2651_CR47
  publication-title: N Engl J Med
  doi: 10.1056/Nejmcp0801652
– volume: 152
  start-page: 1042
  year: 2007
  ident: 2651_CR29
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0707454
– volume: 63
  start-page: 1138
  year: 2014
  ident: 2651_CR153
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.113.01274
– volume: 367
  start-page: 2204
  year: 2012
  ident: 2651_CR133
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1208799
– volume: 34
  start-page: 5813
  year: 2013
  ident: 2651_CR212
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2013.04.026
– volume: 116
  start-page: 1784
  year: 2006
  ident: 2651_CR79
  publication-title: J Clin Investig
  doi: 10.1172/JCI29126
– ident: 2651_CR33
  doi: 10.3317/jraas.2004.041
– volume: 66
  start-page: 265
  year: 2005
  ident: 2651_CR91
  publication-title: Cardiovasc Res
  doi: 10.1016/j.cardiores.2004.12.026
– volume: 75
  start-page: 29
  year: 2007
  ident: 2651_CR130
  publication-title: Cardiovasc Res
  doi: 10.1016/j.cardiores.2007.04.007
– volume: 52
  start-page: 415
  year: 2000
  ident: 2651_CR32
  publication-title: Pharmacol Rev
– volume: 68
  start-page: 85
  year: 1991
  ident: 2651_CR56
  publication-title: Am J Cardiol
  doi: 10.1016/0002-9149(91)90716-X
– volume: 323
  start-page: 359
  year: 2014
  ident: 2651_CR34
  publication-title: Exp Cell Res
  doi: 10.1016/j.yexcr.2014.03.006
– volume: 95
  start-page: 1247
  year: 1997
  ident: 2651_CR207
  publication-title: Circulation
  doi: 10.1161/01.CIR.95.5.1247
– volume: 33
  start-page: 1058
  year: 2014
  ident: 2651_CR21
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000358676
– volume: 172
  start-page: 4443
  year: 2015
  ident: 2651_CR131
  publication-title: Br J Pharmacol
  doi: 10.1111/bph.13225
– volume: 59
  start-page: 76
  year: 2012
  ident: 2651_CR51
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.111.179457
– volume: 298
  start-page: F683
  year: 2010
  ident: 2651_CR120
  publication-title: Am J Physiol-Renal Physiol
  doi: 10.1152/ajprenal.00503.2009
– volume: 165
  start-page: 459
  year: 2003
  ident: 2651_CR73
  publication-title: Ugeskr Laeger
– volume: 61
  start-page: 21
  year: 2018
  ident: 2651_CR76
  publication-title: Diabetologia
  doi: 10.1007/s00125-017-4390-4
– volume: 4
  start-page: 68
  year: 2013
  ident: 2651_CR38
  publication-title: Front Endocrinol (Lausanne)
  doi: 10.3389/fendo.2013.00068
– volume: 292
  start-page: H736
  year: 2007
  ident: 2651_CR63
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00937.2006
– volume: 302
  start-page: C597
  year: 2012
  ident: 2651_CR104
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00331.2011
– volume: 62
  start-page: 3887
  year: 2013
  ident: 2651_CR144
  publication-title: Diabetes
  doi: 10.2337/db13-0095
– volume: 93
  start-page: 2372
  year: 1994
  ident: 2651_CR27
  publication-title: J Clin Investig
  doi: 10.1172/Jci117243
– volume: 169
  start-page: 798
  year: 2009
  ident: 2651_CR116
  publication-title: Arch Intern Med
  doi: 10.1001/archinternmed.2009.21
– volume: 133
  start-page: 2459
  year: 2016
  ident: 2651_CR100
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.116.022194
– volume: 107
  start-page: 539
  year: 2004
  ident: 2651_CR69
  publication-title: Clin Sci
  doi: 10.1042/CS20040057
– volume: 12
  start-page: 169
  year: 2013
  ident: 2651_CR208
  publication-title: Cardiovasc Diabetol
  doi: 10.1186/1475-2840-12-169
– volume: 119
  start-page: 524
  year: 2009
  ident: 2651_CR11
  publication-title: J Clin Investig
  doi: 10.1172/JCI36703
– ident: 2651_CR70
  doi: 10.1016/S0140-6736(99)12323-7
– volume: 55
  start-page: 1544
  year: 2012
  ident: 2651_CR72
  publication-title: Diabetologia
  doi: 10.1007/s00125-012-2495-3
– volume: 47
  start-page: 604
  year: 2012
  ident: 2651_CR166
  publication-title: Eur J Pharm Sci
  doi: 10.1016/j.ejps.2012.04.018
– ident: 2651_CR213
  doi: 10.1371/journal.pone.0012323
– volume: 23
  start-page: S9
  year: 2005
  ident: 2651_CR45
  publication-title: J Hypertens
  doi: 10.1097/01.hjh.0000165623.72310.dd
– volume: 355
  start-page: 1575
  year: 2000
  ident: 2651_CR53
  publication-title: Lancet
  doi: 10.1016/S0140-6736(00)02212-1
– volume: 76
  start-page: 280
  year: 2007
  ident: 2651_CR25
  publication-title: Cardiovasc Res
  doi: 10.1016/j.cardiores.2007.06.022
– volume: 82
  start-page: S42
  year: 2008
  ident: 2651_CR65
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/j.diabres.2008.09.017
– volume: 35
  start-page: 4
  year: 2012
  ident: 2651_CR81
  publication-title: Hypertens Res
  doi: 10.1038/hr.2011.173
– volume: 133
  start-page: e38
  year: 2016
  ident: 2651_CR115
  publication-title: Circulation
  doi: 10.1161/CIR.0000000000000350
– volume: 24
  start-page: 796
  year: 2013
  ident: 2651_CR165
  publication-title: J Nutr Biochem
  doi: 10.1016/j.jnutbio.2012.04.013
– volume: 59
  start-page: 1778
  year: 2016
  ident: 2651_CR24
  publication-title: Diabetologia
  doi: 10.1007/s00125-016-3977-5
– volume: 42
  start-page: 328
  year: 2003
  ident: 2651_CR39
  publication-title: J Am Coll Cardiol
  doi: 10.1016/S0735-1097(03)00625-9
– volume: 15
  start-page: 409
  year: 2013
  ident: 2651_CR99
  publication-title: Curr Hypertens Rep
  doi: 10.1007/s11906-013-0356-1
– volume: 161
  start-page: 1
  year: 2010
  ident: 2651_CR118
  publication-title: Regul Pept
  doi: 10.1016/j.regpep.2010.02.001
– volume: 5
  start-page: 1215
  year: 2009
  ident: 2651_CR141
  publication-title: Autophagy
  doi: 10.4161/auto.5.8.10153
– ident: 2651_CR26
  doi: 10.3389/Fphar.2016.00024
– volume: 485
  start-page: 251
  year: 2012
  ident: 2651_CR128
  publication-title: Nature
  doi: 10.1038/nature10992
– volume: 426
  start-page: 43
  year: 2010
  ident: 2651_CR209
  publication-title: Biochem J
  doi: 10.1042/Bj20090976
– volume: 59
  start-page: 1195
  year: 2012
  ident: 2651_CR134
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.112.191650
– volume: 292
  start-page: H666
  year: 2007
  ident: 2651_CR12
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00372.2006
– volume: 97
  start-page: 3A
  year: 2006
  ident: 2651_CR67
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2005.11.010
– volume: 12
  start-page: 579
  year: 2016
  ident: 2651_CR150
  publication-title: Autophagy
  doi: 10.1080/15548627.2016.1145326
– volume: 123
  start-page: 5319
  year: 2013
  ident: 2651_CR147
  publication-title: J Clin Invest
  doi: 10.1172/JCI71171
– volume: 62
  start-page: E147
  year: 2013
  ident: 2651_CR202
  publication-title: J Am Coll Cardiol
  doi: 10.1016/j.jacc.2013.05.019
– volume: 103
  start-page: 137
  year: 2014
  ident: 2651_CR64
  publication-title: Diabetes Res Clin Pract
  doi: 10.1016/j.diabres.2013.11.002
– volume: 6
  start-page: 42
  year: 2008
  ident: 2651_CR206
  publication-title: Electrolyte Blood Press
  doi: 10.5049/EBP.2008.6.1.42
– volume: 11
  start-page: 413
  year: 2014
  ident: 2651_CR77
  publication-title: Nat Rev Cardiol
  doi: 10.1038/nrcardio.2014.59
– volume: 53
  start-page: 294
  year: 2012
  ident: 2651_CR95
  publication-title: Yonsei Med J
  doi: 10.3349/ymj.2012.53.2.294
– volume: 22
  start-page: 732
  year: 2009
  ident: 2651_CR3
  publication-title: J Am Soc Echocardiogr
  doi: 10.1016/j.echo.2009.03.028
– volume: 652
  start-page: 126
  year: 2011
  ident: 2651_CR173
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2010.10.081
– volume: 110
  start-page: 3221
  year: 2004
  ident: 2651_CR174
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000147233.10318.23
– volume: 6
  year: 2011
  ident: 2651_CR210
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0016239
– volume: 342
  start-page: 145
  year: 2000
  ident: 2651_CR211
  publication-title: N Engl J Med
  doi: 10.1056/NEJM200001203420301
– volume: 23
  start-page: 69
  year: 2015
  ident: 2651_CR22
  publication-title: Zhonghua Gan Zang Bing Za Zhi
– volume: 291
  start-page: H336
  year: 2006
  ident: 2651_CR214
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.01307.2005
– volume: 125
  start-page: 117
  year: 2018
  ident: 2651_CR23
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2018.08.028
– volume: 23
  start-page: 538
  year: 2013
  ident: 2651_CR117
  publication-title: Jcpsp-J Coll Physicians Surg Pakistan
– volume: 14
  start-page: 831
  year: 2006
  ident: 2651_CR55
  publication-title: Mol Ther
  doi: 10.1016/j.ymthe.2006.08.009
– volume: 14
  start-page: 10497
  year: 2013
  ident: 2651_CR156
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms140510497
– volume: 7
  start-page: 154
  year: 2011
  ident: 2651_CR172
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.7.154
– volume: 88
  start-page: 233
  year: 2010
  ident: 2651_CR86
  publication-title: Can J Physiol Pharmacol
  doi: 10.1139/Y10-016
– volume: 22
  start-page: 2193
  year: 2014
  ident: 2651_CR89
  publication-title: Obesity
  doi: 10.1002/oby.20837
– volume: 11
  start-page: 56
  year: 2011
  ident: 2651_CR83
  publication-title: Curr DiabRep
  doi: 10.1007/s11892-010-0163-x
– volume: 52
  start-page: 11
  year: 2000
  ident: 2651_CR87
  publication-title: Pharmacol Rev
– volume: 98
  start-page: 33
  year: 2002
  ident: 2651_CR157
  publication-title: Cardiology
  doi: 10.1159/000064682
– ident: 2651_CR41
  doi: 10.1186/1475-2840-8-58
– volume: 50
  start-page: 384
  year: 2007
  ident: 2651_CR195
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.107.089284
– volume: 26
  start-page: 1369
  year: 2005
  ident: 2651_CR30
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehi225
– volume: 28
  start-page: 851
  year: 1996
  ident: 2651_CR175
  publication-title: J Mol Cell Cardiol
  doi: 10.1006/jmcc.1996.0080
– volume: 99
  start-page: 129
  year: 2013
  ident: 2651_CR179
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvt065
– volume: 119
  start-page: 1272
  year: 2009
  ident: 2651_CR15
  publication-title: Circulation
  doi: 10.1161/Circulationaha.108.792101
– volume: 160
  start-page: 1273
  year: 2010
  ident: 2651_CR103
  publication-title: Br J Pharmacol
  doi: 10.1111/j.1476-5381.2010.00750.x
– volume: 16
  start-page: S3
  issue: Suppl 1
  year: 2005
  ident: 2651_CR186
  publication-title: Coron Artery Dis
  doi: 10.1097/00019501-200511001-00002
– volume: 7
  start-page: 1254
  year: 2011
  ident: 2651_CR199
  publication-title: Autophagy
  doi: 10.4161/auto.7.10.16740
– volume: 133
  start-page: 1249
  year: 2016
  ident: 2651_CR161
  publication-title: Circulation
  doi: 10.1161/Circulationaha.115.020502
– volume: 106
  start-page: 246
  year: 2002
  ident: 2651_CR19
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000021122.63813.32
– volume: 36
  start-page: 208
  year: 2013
  ident: 2651_CR94
  publication-title: Arch Pharmacal Res
  doi: 10.1007/s12272-013-0023-8
– volume: 288
  start-page: 15520
  year: 2013
  ident: 2651_CR182
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.459792
– volume: 36
  start-page: 360
  year: 2000
  ident: 2651_CR17
  publication-title: Hypertension
  doi: 10.1161/01.HYP.36.3.360
– volume: 288
  start-page: 18077
  year: 2013
  ident: 2651_CR201
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M113.474650
– volume: 350
  start-page: 664
  year: 2004
  ident: 2651_CR137
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa031314.350/7/664[pii]
– volume: 52
  start-page: 1019
  year: 2012
  ident: 2651_CR16
  publication-title: J Mol Cell Cardiol
  doi: 10.1016/j.yjmcc.2012.02.001
– volume: 83
  start-page: 653
  year: 2012
  ident: 2651_CR92
  publication-title: Biochem Pharmacol
  doi: 10.1016/j.bcp.2011.11.018
– volume: 107
  start-page: 372
  year: 2016
  ident: 2651_CR132
  publication-title: Pharmacol Res
  doi: 10.1016/j.phrs.2016.02.026
– volume: 85
  start-page: 473
  year: 2010
  ident: 2651_CR107
  publication-title: Cardiovasc Res
  doi: 10.1093/cvr/cvp305
– volume: 112
  start-page: 1104-+
  year: 2013
  ident: 2651_CR93
  publication-title: Circ Res
  doi: 10.1161/Circresaha.113.301077
– ident: 2651_CR139
  doi: 10.1155/2015/981242
– ident: 2651_CR121
  doi: 10.1371/journal.pone.0093145
– volume: 128
  start-page: 227
  year: 2015
  ident: 2651_CR190
  publication-title: Clin Sci (Lond)
  doi: 10.1042/CS20130515
– volume: 52
  start-page: 542
  year: 2008
  ident: 2651_CR40
  publication-title: Hypertension
  doi: 10.1161/Hypertensionaha.108.114280
– volume: 12
  start-page: 144
  year: 2016
  ident: 2651_CR75
  publication-title: Nat Rev Endocrinol
  doi: 10.1038/nrendo.2015.216
– volume: 19
  start-page: 3033
  year: 2013
  ident: 2651_CR90
  publication-title: Curr Pharm Des
  doi: 10.2174/1381612811319170009
– volume: 308
  start-page: H1007
  year: 2015
  ident: 2651_CR68
  publication-title: Am J Physiol Heart Circ Physiol
  doi: 10.1152/ajpheart.00563.2014
– volume: 106
  start-page: 8665
  year: 2009
  ident: 2651_CR148
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0903485106
– volume: 296
  start-page: E262
  year: 2009
  ident: 2651_CR61
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.90678.2008
– volume: 8
  start-page: 480
  year: 2007
  ident: 2651_CR176
  publication-title: Eur J Echocardiogr
  doi: 10.1016/j.euje.2006.09.005
– volume: 309
  start-page: C593
  year: 2015
  ident: 2651_CR105
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00069.2015
– volume: 8
  year: 2013
  ident: 2651_CR192
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0081296
– volume: 100
  start-page: 312
  year: 2015
  ident: 2651_CR78
  publication-title: Exp Physiol
  doi: 10.1113/expphysiol.2014.084095
– volume: 94
  start-page: 1211
  year: 2004
  ident: 2651_CR6
  publication-title: Circ Res
  doi: 10.1161/01.Res.0000126501.34994.96
– volume: 115
  start-page: 3587
  year: 2005
  ident: 2651_CR114
  publication-title: J Clin Invest
  doi: 10.1172/JCI25151
– volume: 57
  start-page: 452
  year: 2011
  ident: 2651_CR10
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.110.162339
– volume: 72
  start-page: 219
  year: 2010
  ident: 2651_CR129
  publication-title: Annu Rev Physiol
  doi: 10.1146/annurev-physiol-021909-135846
– volume: 39
  start-page: 237
  year: 2016
  ident: 2651_CR193
  publication-title: Hypertens Res
  doi: 10.1038/hr.2015.141
– volume: 57
  start-page: 3297
  year: 2008
  ident: 2651_CR164
  publication-title: Diabetes
  doi: 10.2337/db08-0805
– volume: 87
  start-page: 1123
  year: 2000
  ident: 2651_CR54
  publication-title: Circ Res
  doi: 10.1161/01.RES.87.12.1123
– volume: 13
  start-page: 619
  year: 2007
  ident: 2651_CR122
  publication-title: Nat Med
  doi: 10.1038/nm1574
– volume: 359
  start-page: 1004
  year: 2002
  ident: 2651_CR98
  publication-title: Lancet
  doi: 10.1016/S0140-6736(02)08090-X
– volume: 16
  start-page: 130
  year: 2016
  ident: 2651_CR59
  publication-title: Cardiovasc Toxicol
  doi: 10.1007/s12012-015-9321-3
– volume: 56
  start-page: 97
  year: 2019
  ident: 2651_CR20
  publication-title: Acta Diabetol
  doi: 10.1007/s00592-018-1220-1
– volume: 5
  start-page: 159
  year: 2011
  ident: 2651_CR162
  publication-title: Ther Adv Cardiovasc Dis
  doi: 10.1177/1753944711409281
– volume: 98
  start-page: 354
  year: 2015
  ident: 2651_CR71
  publication-title: J AOAC Int
  doi: 10.5740/jaoacint.14-179
– volume: 148
  start-page: 3773
  year: 2007
  ident: 2651_CR167
  publication-title: Endocrinology
  doi: 10.1210/en.2006-1691
– volume: 12
  start-page: 454
  year: 2010
  ident: 2651_CR149
  publication-title: Eur J Heart Fail
  doi: 10.1093/eurjhf/hfq022
– volume: 7
  start-page: 1077
  year: 2011
  ident: 2651_CR170
  publication-title: Int J Biol Sci
  doi: 10.7150/ijbs.7.1077
– volume: 94
  start-page: 1630
  year: 2004
  ident: 2651_CR124
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000130944.49657.b8
– volume: 53
  start-page: 1032
  year: 2009
  ident: 2651_CR140
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.108.128488
– volume: 102
  start-page: 488
  year: 2008
  ident: 2651_CR43
  publication-title: Circ Res
  doi: 10.1161/CIRCRESAHA.107.162800
– volume: 62
  start-page: 223
  year: 2013
  ident: 2651_CR178
  publication-title: Diabetes
  doi: 10.2337/db12-0177
– volume: 97
  start-page: E642
  year: 2012
  ident: 2651_CR136
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jc.2011-2542
– volume: 96
  start-page: 4239
  year: 1997
  ident: 2651_CR218
  publication-title: Circulation
  doi: 10.1161/01.cir.96.12.4239
– volume: 79
  start-page: 121
  year: 2006
  ident: 2651_CR52
  publication-title: Life Sci
  doi: 10.1016/j.lfs.2005.12.036
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Snippet Experimental and clinical evidence suggests that diabetic subjects are predisposed to a distinct cardiovascular dysfunction, known as diabetic cardiomyopathy...
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SubjectTerms Aldosterone
Angiotensin
Angiotensin II - metabolism
Animals
Autophagy
Biomedical and Life Sciences
Biomedicine
Cardiomyocytes
Cardiomyopathy
Cell Biology
Congestive heart failure
Diabetes
Diabetes mellitus
Diabetic Cardiomyopathies - etiology
Diabetic Cardiomyopathies - metabolism
Heart failure
Human Physiology
Humans
Hypertrophy
Inflammation - metabolism
Invited Review
Mitochondria
Molecular Medicine
Morbidity
Neurosciences
Obesity - complications
Obesity - metabolism
Oxidative Stress
Peptidyl-Dipeptidase A - metabolism
Prognosis
Receptors
Receptors, Angiotensin - metabolism
Renin
Renin-Angiotensin System
Ventricle
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Title Understanding diabetes-induced cardiomyopathy from the perspective of renin angiotensin aldosterone system
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