Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia

• Published in: Scientific reports Vol. 14; no. 1; pp. 6084 - 13
• Main Authors: Ikhlef, Léa, Yassine, May, Chandouri, Boutaîna, Rivière, Léa, Naves, Thomas, Dmytruk, Natalya, Gachard, Nathalie, Jauberteau, Marie-Odile, Gallet, Paul-François
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/555; 631/67/1990/283/1895; Apoptosis; B-cell receptor; Cell survival; Chronic lymphocytic leukemia; Cytotoxicity; Humanities and Social Sciences; Kinases; Leukemia; Lymphocytes B; multidisciplinary; Neurotensin; Peptides; Proteins; Science; Science (multidisciplinary); TrkB receptors; Tropomyosin

Current therapies that target the B-cell receptor pathway or the inhibition of anti-apoptotic proteins do not prevent the progressive forms of chronic lymphocytic leukemia (CLL), have low long-term efficacy and are subject to therapeutic resistance. Deciphering the mechanisms of leukemic cell surviv...