Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling

• Published in: Nature communications Vol. 16; no. 1; pp. 1865 - 19
• Main Authors: Yu, Jinjin, Li, Yingke, Li, Yiming, Liu, Xiaotian, Huo, Qingyang, Wu, Nan, Zhang, Yangxia, Zeng, Taoling, Zhang, Yong, Li, Henry You, Lian, Jie, Zhou, Jihong, Moses, Emmanuel Jairaj, Geng, Jian, Lin, Juntang, Li, Wei, Zhu, Xinxing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 38/1; 38/15; 38/47; 38/89; 38/91; 631/45/275; 631/80/86/2366; 96/95; Animals; Chromatin; Fibrosis; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Humanities and Social Sciences; Humans; Lung - metabolism; Lung - pathology; Lung diseases; Male; Mice; multidisciplinary; NIMA-Related Kinases - genetics; NIMA-Related Kinases - metabolism; Phosphorylation; Pulmonary fibrosis; Pulmonary Fibrosis - genetics; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; Science; Science (multidisciplinary); Signal Transduction; Smad protein; Smad Proteins - metabolism; Smad2 protein; Smad4 protein; Smad4 Protein - genetics; Smad4 Protein - metabolism; Transcription activation; Ubiquitination

The transcriptional repressor FOXN3 plays a key role in regulating pulmonary inflammatory responses, which are crucial in the development of pulmonary fibrosis. However, its specific regulatory function in lung fibrosis remains unclear. Here, we show that FOXN3 suppresses pulmonary fibrosis by inhib...