Burkholderia pseudomallei BipD modulates host mitophagy to evade killing

• Published in: Nature communications Vol. 15; no. 1; pp. 4740 - 17
• Main Authors: Nan, Dongqi, Rao, Chenglong, Tang, Zhiheng, Yang, Wenbo, Wu, Pan, Chen, Jiangao, Xia, Yupei, Yan, Jingmin, Liu, Wenzheng, Zhang, Ziyuan, Hu, Zhiqiang, Chen, Hai, Liao, Yaling, Mao, Xuhu, Liu, Xiaoyun, Zou, Quanming, Li, Qian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.06.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/109; 13/31; 13/89; 14/19; 14/28; 14/34; 14/35; 631/250/2161; 631/326/421; 631/326/88; 64/60; 82/1; 82/29; 82/58; 82/83; Animals; Autophagy; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Burkholderia pseudomallei; Burkholderia pseudomallei - genetics; Burkholderia pseudomallei - metabolism; Burkholderia pseudomallei - pathogenicity; Burkholderia pseudomallei - physiology; HEK293 Cells; Homeostasis; Host-Pathogen Interactions; Humanities and Social Sciences; Humans; Infectious diseases; Macrophages; Macrophages - metabolism; Macrophages - microbiology; Melioidosis - metabolism; Melioidosis - microbiology; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondria - metabolism; Mitochondrial Membranes - metabolism; Mitophagy; multidisciplinary; Proteins; Quality control; RAW 264.7 Cells; Reactive Oxygen Species - metabolism; Science; Science (multidisciplinary); Substrates; Survival; Type III Secretion Systems - genetics; Type III Secretion Systems - metabolism; Ubiquitin-protein ligase; Ubiquitination

Mitophagy is critical for mitochondrial quality control and function to clear damaged mitochondria. Here, we found that Burkholderia pseudomallei maneuvered host mitophagy for its intracellular survival through the type III secretion system needle tip protein BipD. We identified BipD, interacting wi...