Functional observation after morphine withdrawal: effects of SJP-005

• Published in: Psychopharmacology Vol. 238; no. 6; pp. 1449 - 1460
• Main Authors: Verster, Joris C., Scholey, Andrew, Dahl, Thomas A., Iversen, Jacqueline M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2021; Springer; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Drug addiction; Drug withdrawal; Hypersensitivity; Ibuprofen; Morphine; Neurosciences; Nonsteroidal anti-inflammatory drugs; Opioids; Original Investigation; Pharmacology/Toxicology; Placebos; Psychiatry; Statistical analysis; Netherlands; Treatment; Buprenorphine; Opioid dependence; SJP-005; Clonidine; Methadone; Opioid use disorder; Lofexidine; Opioid withdrawal

Rationale and objective SJP-005 (ketotifen and ibuprofen) is being developed as a potential new treatment for opioid withdrawal. Three studies were conducted to evaluate the early phase (acute, day 1) and late phase (days 2–12) effects of SJP-005 on discontinuation-induced morphine withdrawal. Metho...