Gene expression changes in sickle cell reticulocytes and their clinical associations

• Published in: Scientific reports Vol. 13; no. 1; pp. 12864 - 11
• Main Authors: Zhang, Xu, Song, Jihyun, Shah, Binal N., Han, Jin, Hassan, Taif, Miasniakova, Galina, Sergueeva, Adelina, Nekhai, Sergei, Machado, Roberto F., Gladwin, Mark T., Saraf, Santosh L., Prchal, Josef T., Gordeuk, Victor R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.08.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/2056; 692/308/575; Anemia, Sickle Cell; Developmental stages; Erythroblasts; Erythroblasts - metabolism; Erythropoiesis; Erythropoiesis - genetics; Gene Expression; Gene mapping; Hemoglobin; Humanities and Social Sciences; Humans; Hypoxia; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; multidisciplinary; Peripheral blood mononuclear cells; Polycythemia; Proteins; Quantitative trait loci; Reticulocytes; Reticulocytes - metabolism; Science; Science (multidisciplinary); Sickle cell disease; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination

Transcriptional changes in compensatory erythropoiesis in sickle cell anemia (SCA) and their disease modulation are unclear. We detected 1226 differentially expressed genes in hemoglobin SS reticulocytes compared to non-anemic hemoglobin AA controls. Assessing developmental expression changes in hem...