Linoleic acid induces human ovarian granulosa cell inflammation and apoptosis through the ER-FOXO1-ROS-NFκB pathway

• Published in: Scientific reports Vol. 14; no. 1; pp. 6392 - 13
• Main Authors: Zhang, Wenying, Wu, Fuju
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/337; 631/45; 631/80; Apoptosis; Dietary fatty acids; Environmental factors; Estrogen receptor; Estrogen receptors; Estrogens; Fatty acids; Follicular fluid; FOXO1 protein; Granulosa cell; Granulosa cells; Humanities and Social Sciences; Inflammation; Linoleic acid; multidisciplinary; NF-κB protein; Oxidative stress; Phenotypes; Polycystic ovary syndrome; Polyunsaturated fatty acids; Reactive oxygen species; Science; Science (multidisciplinary); Polycystic ovary syndrome; Estrogen receptor; Granulosa cell; Dietary fatty acids; Linoleic acid; Apoptosis

Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinological disorder influenced by a combination of genetic and environmental factors. Linoleic acid (LA) is a widely consumed ω-6 polyunsaturated fatty acid, accounting for approximately 80% of daily fatty acid intake. Building upon th...