Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis

• Published in: Nature communications Vol. 14; no. 1; p. 8474
• Main Authors: Patitucci, Cecilia, Hernández-Camacho, Juan Diego, Vimont, Elodie, Yde, Sonny, Cokelaer, Thomas, Chaze, Thibault, Giai Gianetto, Quentin, Matondo, Mariette, Gazi, Anastasia, Nemazanyy, Ivan, Stroud, David A., Hock, Daniella H., Donnarumma, Erminia, Wai, Timothy
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.12.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 14/1; 14/28; 147/143; 38/91; 42; 42/34; 42/41; 42/89; 49/88; 631/443/319/1642/2037; 631/443/319/333/1465; 631/80/304; 631/80/642/333/1465; 64/60; 82/58; 96/106; 96/63; Ablation; Accumulation; Animals; Apoptosis; Deletion; Diet; Fatty liver; Fatty Liver - genetics; Fatty Liver - metabolism; Fission; Hepatocytes; High fat diet; Humanities and Social Sciences; Lipids; Liver; Liver - metabolism; Liver diseases; Liver Diseases - metabolism; Membrane permeability; Metabolism; Mice; Mice, Knockout; Mitochondria - metabolism; Mitochondria, Liver - metabolism; Mitochondrial permeability transition pore; multidisciplinary; Oxidative phosphorylation; Phosphorylation; Respiration; Science; Science (multidisciplinary); Steatosis

Hepatic steatosis is the result of imbalanced nutrient delivery and metabolism in the liver and is the first hallmark of Metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is the most common chronic liver disease and involves the accumulation of excess lipids in hepatocytes, inf...