The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains

• Published in: Scientific reports Vol. 13; no. 1; p. 17137
• Main Authors: Oyarce-Pezoa, Sebastián, Rucatti, Guilherme Gischkow, Muñoz-Carvajal, Francisco, Sanhueza, Nicole, Gomez, Wileidy, Espinoza, Sandra, Leiva, Mario, García, Nicolás, Ponce, Daniela P., SanMartín, Carol D., Rojas-Rivera, Diego, Salvadores, Natalia, Behrens, Maria I., Woehlbier, Ute, Calegaro-Nassif, Melissa, Sanhueza, Mario
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.10.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 692/699; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animals; Autophagy; Autophagy - genetics; Biodegradation; Brain - metabolism; Cognitive ability; Cortex (frontal); Drosophila melanogaster - genetics; Drosophila melanogaster - metabolism; Homeostasis; Humanities and Social Sciences; Humans; Insects; Localization; Lymphocytes; multidisciplinary; Nervous system; Neurodegenerative diseases; Organelles; Peptide Fragments - metabolism; Peptides; Proteins; Quality control; Science; Science (multidisciplinary)

Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by protein accumulation in the brain as a main neuropathological hallmark. Among them, Aβ42 peptides tend to aggregate and create oligomers and plaques. Macroautophagy, a form of autophagy characterized by a d...