Efficient in planta production of amidated antimicrobial peptides that are active against drug-resistant ESKAPE pathogens

• Published in: Nature communications Vol. 14; no. 1; pp. 1464 - 16
• Main Authors: Chaudhary, Shahid, Ali, Zahir, Tehseen, Muhammad, Haney, Evan F., Pantoja-Angles, Aarón, Alshehri, Salwa, Wang, Tiannyu, Clancy, Gerard J., Ayach, Maya, Hauser, Charlotte, Hong, Pei-Ying, Hamdan, Samir M., Hancock, Robert E. W., Mahfouz, Magdy
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 38/109; 38/44; 42; 631/1647/1511; 631/449/447/2311; 631/61/447/2311; 631/61/51/2313; 82/16; 82/29; 82/58; 82/80; 82/81; 82/83; Animals; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Antimicrobial Cationic Peptides - biosynthesis; Antimicrobial Cationic Peptides - pharmacology; Antimicrobial peptides; Antimicrobial Peptides - biosynthesis; Biofilms; Biological activity; Drug resistance; Drug Resistance, Bacterial - drug effects; Economic analysis; Economics; Enzymes; Glycine; Humanities and Social Sciences; Industrial applications; Mammals; multidisciplinary; Nicotiana - chemistry; Nicotiana - genetics; Nicotiana benthamiana; Oxygenase; Pathogens; Peptides; Plants; Science; Science (multidisciplinary); Synergism; Transgenic plants

Antimicrobial peptides (AMPs) are promising next-generation antibiotics that can be used to combat drug-resistant pathogens. However, the high cost involved in AMP synthesis and their short plasma half-life render their clinical translation a challenge. To address these shortcomings, we report effic...