The evolution of non-small cell lung cancer metastases in TRACERx

• Published in: Nature (London) Vol. 616; no. 7957; pp. 534 - 542
• Main Authors: Al Bakir, Maise, Huebner, Ariana, Martínez-Ruiz, Carlos, Grigoriadis, Kristiana, Watkins, Thomas B. K., Pich, Oriol, Moore, David A., Veeriah, Selvaraju, Ward, Sophia, Laycock, Joanne, Johnson, Diana, Rowan, Andrew, Razaq, Maryam, Akther, Mita, Naceur-Lombardelli, Cristina, Prymas, Paulina, Toncheva, Antonia, Hessey, Sonya, Dietzen, Michelle, Colliver, Emma, Frankell, Alexander M., Bunkum, Abigail, Lim, Emilia L., Karasaki, Takahiro, Abbosh, Christopher, Hiley, Crispin T., Hill, Mark S., Cook, Daniel E., Wilson, Gareth A., Salgado, Roberto, Nye, Emma, Stone, Richard Kevin, Fennell, Dean A., Price, Gillian, Kerr, Keith M., Naidu, Babu, Middleton, Gary, Summers, Yvonne, Lindsay, Colin R., Blackhall, Fiona H., Cave, Judith, Blyth, Kevin G., Nair, Arjun, Ahmed, Asia, Taylor, Magali N., Procter, Alexander James, Falzon, Mary, Lawrence, David, Navani, Neal, Thakrar, Ricky M., Janes, Sam M., Papadatos-Pastos, Dionysis, Forster, Martin D., Lee, Siow Ming, Ahmad, Tanya, Quezada, Sergio A., Peggs, Karl S., Van Loo, Peter, Dive, Caroline, Hackshaw, Allan, Birkbak, Nicolai J., Zaccaria, Simone, Jamal-Hanjani, Mariam, McGranahan, Nicholas, Swanton, Charles
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.04.2023; Nature Publishing Group
• Subjects: 45; 45/22; 45/23; 631/114; 631/181/2474; 631/208/69; 631/67/1612/1350; 631/67/322; Cancer therapies; Carcinoma, Non-Small-Cell Lung - pathology; Clonal Evolution; Clone Cells - pathology; Cloning; Cohort Studies; Disease control; Disease Progression; Divergence; Evolution; Evolution, Molecular; Genomes; Humanities and Social Sciences; Humans; Lung cancer; Lung diseases; Lung Neoplasms - pathology; Lymph nodes; Lymphatic system; Mann-Whitney U test; Metastases; Metastasis; multidisciplinary; Mutation; Neoplasm Metastasis - diagnosis; Neoplasm Metastasis - pathology; Neoplasm Recurrence, Local; Non-small cell lung carcinoma; Patients; Positive selection; Quality control; Sampling; Science; Science (multidisciplinary); Small cell lung carcinoma; Smoking; Tumors

Metastatic disease is responsible for the majority of cancer-related deaths 1 . We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of...