Comprehensive analysis of disulfidptosis-related genes reveals the effect of disulfidptosis in ulcerative colitis

• Published in: Scientific reports Vol. 14; no. 1; pp. 15705 - 18
• Main Authors: Song, Huixian, Zhang, Fengrui, Bai, Xinyu, Liang, Hao, Niu, Junkun, Miao, Yinglei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/1305; 692/4020/1503/257/1389; 692/53/2421; Animals; Apoptosis; Apoptosis - genetics; Bioinformatics; Cell death; Colitis, Ulcerative - chemically induced; Colitis, Ulcerative - genetics; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; Computational Biology - methods; Dextran; Dextran Sulfate; Disease Models, Animal; Disulfidptosis; Female; Gene expression; Gene Expression Profiling; Homeostasis; Humanities and Social Sciences; Humans; Immune infiltration; Infiltration; Inflammatory bowel disease; Inflammatory bowel diseases; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine; Machine learning; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mortality; mRNA; Mucosa; multidisciplinary; Pathogenesis; Science; Science (multidisciplinary); Ulcerative colitis; Weighted gene co-expression network analysis; Western blotting; Disulfidptosis; Machine learning; Immune infiltration; Ulcerative colitis; Weighted gene co-expression network analysis

Ulcerative colitis (UC) is a chronic inflammatory condition of the intestinal tract. Various programmed cell death pathways in the intestinal mucosa are crucial to the pathogenesis of UC. Disulfidptosis, a recently identified form of programmed cell death, has not been extensively reported in the co...